Regulation of ion channels by phosphatidylinositol 4,5-bisphosphate

Phosphatidylinositol 4,5-bisphosphate is a signaling phospholipid of the plasma membrane that has a dynamically changing concentration. In addition to being the precursor of inositol trisphosphate and diacylglycerol, it complexes with and regulates many cytoplasmic and membrane proteins. Recent work...

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Veröffentlicht in:Current opinion in neurobiology Jg. 15; H. 3; S. 370 - 378
Hauptverfasser: Suh, Byung-Chang, Hille, Bertil
Format: Journal Article
Sprache:Englisch
Veröffentlicht: England Elsevier Ltd 01.06.2005
Schlagworte:
Cell Membrane - chemistry
Cell Membrane - physiology
Ion Channels - physiology
Phosphatidylinositol 4,5-Diphosphate - chemistry
Phosphatidylinositol 4,5-Diphosphate - metabolism
ISSN:0959-4388, 1873-6882
Online-Zugang:Volltext
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Zusammenfassung:Phosphatidylinositol 4,5-bisphosphate is a signaling phospholipid of the plasma membrane that has a dynamically changing concentration. In addition to being the precursor of inositol trisphosphate and diacylglycerol, it complexes with and regulates many cytoplasmic and membrane proteins. Recent work has characterized the regulation of a wide range of ion channels by phosphatidylinositol 4,5-bisphosphate, helping to redefine the role of this lipid in cells and in neurobiology. In most cases, phosphatidylinositol 4,5-bisphosphate increases channel activity, and its hydrolysis by phospholipase C reduces channel activity.
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ISSN:0959-4388
1873-6882
DOI:10.1016/j.conb.2005.05.005