Early-Phase Studies of Biomarkers: What Target Sensitivity and Specificity Values Might Confer Clinical Utility?

Many cancer biomarker research studies seek to develop markers that can accurately detect or predict future onset of disease. To design and evaluate these studies, one must specify the levels of accuracy sought. However, justified target levels are rarely available. We describe a way to calculate ta...

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Bibliographic Details
Published in:	Clinical chemistry (Baltimore, Md.) Vol. 62; no. 5; pp. 737 - 742
Main Authors:	Pepe, Margaret S, Janes, Holly, Li, Christopher I, Bossuyt, Patrick M, Feng, Ziding, Hilden, Jørgen
Format:	Journal Article
Language:	English
Published:	England Oxford University Press 01.05.2016
Subjects:	Aged Biomarkers Biomarkers, Tumor - analysis Breast Neoplasms - diagnosis Clinical outcomes Colonic Neoplasms - diagnosis Costs Decision theory Design Female Funding Humans Middle Aged Ovarian cancer Ovarian Neoplasms - diagnosis Sensitivity and Specificity
ISSN:	0009-9147, 1530-8561
Online Access:	Get full text
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