Long noncoding RNA UCA1 from hypoxia-conditioned hMSC-derived exosomes: a novel molecular target for cardioprotection through miR-873-5p/XIAP axis

Exosomes (Exo) secreted from mesenchymal stem cells (hMSCs) are protective against myocardial injury. The purpose of the study was to investigate the role and mechanisms by which exosomes promote cardiomyocyte survival and function following myocardial infarction (MI). hMSCs were cultured under hypo...

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Vydáno v:	Cell death & disease Ročník 11; číslo 8; s. 696
Hlavní autoři:	Sun, Ling, Zhu, Wenwu, Zhao, Pengcheng, Wang, Qingjie, Fan, Baohan, Zhu, Yeqian, Lu, Yao, Chen, Qiushi, Zhang, Jian, Zhang, Fengxiang
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	London Nature Publishing Group UK 10.08.2020 Springer Nature B.V
Témata:	631/337/384/2568 631/532/2074 Adult Aged Animals Antibodies Apoptosis - genetics Biochemistry Biomedical and Life Sciences Bladder cancer Cardiomyocytes Cell Biology Cell Culture China Exosomes Exosomes - genetics Exosomes - metabolism Female Humans Hypoxia Hypoxia - pathology Immunology Life Sciences Male Mesenchymal Stem Cells - metabolism Mesenchyme MicroRNAs - genetics Middle Aged Myocardial infarction Myocardial Infarction - metabolism Myocytes, Cardiac - metabolism Myocytes, Cardiac - pathology Phosphorylation Rats Rats, Sprague-Dawley Ribonucleic acid RNA RNA, Long Noncoding - genetics Stem cell transplantation Stem cells Urothelial carcinoma X-Linked Inhibitor of Apoptosis Protein - genetics X-Linked Inhibitor of Apoptosis Protein - metabolism XIAP protein China
ISSN:	2041-4889, 2041-4889
On-line přístup:	Získat plný text
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