Fibrillin-1 and elastin are differentially expressed in hypertrophic scars and keloids
Hypertrophic scars and keloids are two forms of excessive cutaneous scarring. Considering the importance of extracellular matrix elements in tissue repair, a morphological and quantitative analysis of the elastic system components (fibrillin‐1 and elastin) was performed in normal skin, normal scars,...
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| Published in: | Wound repair and regeneration Vol. 12; no. 2; pp. 169 - 174 |
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| Main Authors: | , , , , |
| Format: | Journal Article |
| Language: | English |
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Oxford, UK; Malden, USA
Blackwell Science Inc
01.03.2004
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| ISSN: | 1067-1927, 1524-475X |
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| Abstract | Hypertrophic scars and keloids are two forms of excessive cutaneous scarring. Considering the importance of extracellular matrix elements in tissue repair, a morphological and quantitative analysis of the elastic system components (fibrillin‐1 and elastin) was performed in normal skin, normal scars, hypertrophic scars, and keloids. In superficial and deep dermis, fibrillin‐1 volume density was significantly higher in normal skin compared with normal scars, hypertrophic scars, and keloids. The fibrillin‐1 volume density did not show differences between hypertrophic scars and keloids in superficial or deep dermis. In superficial dermis, elastin volume density was higher in normal skin compared with normal scars, hypertrophic scars, and keloids. In deep dermis, the elastin volume density was higher in keloids compared with normal skins, normal scars, and hypertrophic scars. We showed that the distribution of fibrillin‐1 and elastin is disrupted in all kinds of scars analyzed, but there are two patterns: one for normal scars and another for excessive scars. |
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| AbstractList | Hypertrophic scars and keloids are two forms of excessive cutaneous scarring. Considering the importance of extracellular matrix elements in tissue repair, a morphological and quantitative analysis of the elastic system components (fibrillin-1 and elastin) was performed in normal skin, normal scars, hypertrophic scars, and keloids. In superficial and deep dermis, fibrillin-1 volume density was significantly higher in normal skin compared with normal scars, hypertrophic scars, and keloids. The fibrillin-1 volume density did not show differences between hypertrophic scars and keloids in superficial or deep dermis. In superficial dermis, elastin volume density was higher in normal skin compared with normal scars, hypertrophic scars, and keloids. In deep dermis, the elastin volume density was higher in keloids compared with normal skins, normal scars, and hypertrophic scars. We showed that the distribution of fibrillin-1 and elastin is disrupted in all kinds of scars analyzed, but there are two patterns: one for normal scars and another for excessive scars. Hypertrophic scars and keloids are two forms of excessive cutaneous scarring. Considering the importance of extracellular matrix elements in tissue repair, a morphological and quantitative analysis of the elastic system components (fibrillin-1 and elastin) was performed in normal skin, normal scars, hypertrophic scars, and keloids. In superficial and deep dermis, fibrillin-1 volume density was significantly higher in normal skin compared with normal scars, hypertrophic scars, and keloids. The fibrillin-1 volume density did not show differences between hypertrophic scars and keloids in superficial or deep dermis. In superficial dermis, elastin volume density was higher in normal skin compared with normal scars, hypertrophic scars, and keloids. In deep dermis, the elastin volume density was higher in keloids compared with normal skins, normal scars, and hypertrophic scars. We showed that the distribution of fibrillin-1 and elastin is disrupted in all kinds of scars analyzed, but there are two patterns: one for normal scars and another for excessive scars.Hypertrophic scars and keloids are two forms of excessive cutaneous scarring. Considering the importance of extracellular matrix elements in tissue repair, a morphological and quantitative analysis of the elastic system components (fibrillin-1 and elastin) was performed in normal skin, normal scars, hypertrophic scars, and keloids. In superficial and deep dermis, fibrillin-1 volume density was significantly higher in normal skin compared with normal scars, hypertrophic scars, and keloids. The fibrillin-1 volume density did not show differences between hypertrophic scars and keloids in superficial or deep dermis. In superficial dermis, elastin volume density was higher in normal skin compared with normal scars, hypertrophic scars, and keloids. In deep dermis, the elastin volume density was higher in keloids compared with normal skins, normal scars, and hypertrophic scars. We showed that the distribution of fibrillin-1 and elastin is disrupted in all kinds of scars analyzed, but there are two patterns: one for normal scars and another for excessive scars. |
| Author | Costa, Andréa M. A. Braune, André S. Desmoulière, Alexis Amadeu, Thaís P. Porto, Luís C. |
| Author_xml | – sequence: 1 givenname: Thaís P. surname: Amadeu fullname: Amadeu, Thaís P. organization: From the Departamento de Histologia e Embriologiaa, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil, and GREFb, INSERM E0362, Université Victor Segalen - Bordeaux II, Bordeaux, France – sequence: 2 givenname: André S. surname: Braune fullname: Braune, André S. organization: From the Departamento de Histologia e Embriologiaa, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil, and GREFb, INSERM E0362, Université Victor Segalen - Bordeaux II, Bordeaux, France – sequence: 3 givenname: Luís C. surname: Porto fullname: Porto, Luís C. organization: From the Departamento de Histologia e Embriologiaa, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil, and GREFb, INSERM E0362, Université Victor Segalen - Bordeaux II, Bordeaux, France – sequence: 4 givenname: Alexis surname: Desmoulière fullname: Desmoulière, Alexis organization: From the Departamento de Histologia e Embriologiaa, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil, and GREFb, INSERM E0362, Université Victor Segalen - Bordeaux II, Bordeaux, France – sequence: 5 givenname: Andréa M. A. surname: Costa fullname: Costa, Andréa M. A. email: amacosta@uerj.br organization: From the Departamento de Histologia e Embriologiaa, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil, and GREFb, INSERM E0362, Université Victor Segalen - Bordeaux II, Bordeaux, France |
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Wound Rep Reg 1999;7: 166-71.DOI: 10.1046/j.1524-475X.1999.00166.x 1987; 14 1989; 60 2004; 84 2001; 90 1970; 102 2000; 114 1994; 130 2002; 10 1999; 341 2002; 115 1999; 141 1996; 90 1988; 96 1996; 284 1998; 138 1998; 111 1999; 7 2001; 23 1966; 30 1990; 186 1996; 106 2001; 20 2003; 33 1993; 122 2001; 276 1986; 103 1976; 57 2002; 29 1997; 183 1995; 26 1988; 8 1997; 38 1999; 113 1977; 79 1999; 155 1999; 112 1975; 5 1990; 94 Kielty CM (e_1_2_6_14_2) 2002; 115 e_1_2_6_31_2 e_1_2_6_18_2 e_1_2_6_19_2 e_1_2_6_12_2 e_1_2_6_35_2 e_1_2_6_13_2 e_1_2_6_34_2 e_1_2_6_10_2 e_1_2_6_33_2 e_1_2_6_11_2 e_1_2_6_32_2 e_1_2_6_16_2 e_1_2_6_39_2 e_1_2_6_17_2 e_1_2_6_38_2 Compton CC (e_1_2_6_30_2) 1989; 60 e_1_2_6_37_2 e_1_2_6_15_2 e_1_2_6_36_2 e_1_2_6_20_2 e_1_2_6_8_2 e_1_2_6_7_2 e_1_2_6_9_2 e_1_2_6_29_2 e_1_2_6_4_2 e_1_2_6_3_2 Ghahary A (e_1_2_6_5_2) 1993; 122 e_1_2_6_6_2 e_1_2_6_24_2 e_1_2_6_23_2 e_1_2_6_2_2 e_1_2_6_22_2 e_1_2_6_21_2 e_1_2_6_28_2 e_1_2_6_27_2 e_1_2_6_26_2 e_1_2_6_25_2 |
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| SubjectTerms | Adolescent Adult Case-Control Studies Child Cicatrix, Hypertrophic - metabolism Cicatrix, Hypertrophic - pathology Elastin - metabolism Female Fibrillin-1 Fibrillins Humans Keloid - metabolism Keloid - pathology Male Microfilament Proteins - metabolism Middle Aged Skin - metabolism Skin - pathology Wound Healing - physiology |
| Title | Fibrillin-1 and elastin are differentially expressed in hypertrophic scars and keloids |
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