Fibrillin-1 and elastin are differentially expressed in hypertrophic scars and keloids

Hypertrophic scars and keloids are two forms of excessive cutaneous scarring. Considering the importance of extracellular matrix elements in tissue repair, a morphological and quantitative analysis of the elastic system components (fibrillin‐1 and elastin) was performed in normal skin, normal scars,...

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Published in:Wound repair and regeneration Vol. 12; no. 2; pp. 169 - 174
Main Authors: Amadeu, Thaís P., Braune, André S., Porto, Luís C., Desmoulière, Alexis, Costa, Andréa M. A.
Format: Journal Article
Language:English
Published: Oxford, UK; Malden, USA Blackwell Science Inc 01.03.2004
Subjects:
Adolescent
Adult
Case-Control Studies
Child
Cicatrix, Hypertrophic - metabolism
Cicatrix, Hypertrophic - pathology
Elastin - metabolism
Female
Fibrillin-1
Fibrillins
Humans
Keloid - metabolism
Keloid - pathology
Male
Microfilament Proteins - metabolism
Middle Aged
Skin - metabolism
Skin - pathology
Wound Healing - physiology
ISSN:1067-1927, 1524-475X
Online Access:Get full text
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Summary:Hypertrophic scars and keloids are two forms of excessive cutaneous scarring. Considering the importance of extracellular matrix elements in tissue repair, a morphological and quantitative analysis of the elastic system components (fibrillin‐1 and elastin) was performed in normal skin, normal scars, hypertrophic scars, and keloids. In superficial and deep dermis, fibrillin‐1 volume density was significantly higher in normal skin compared with normal scars, hypertrophic scars, and keloids. The fibrillin‐1 volume density did not show differences between hypertrophic scars and keloids in superficial or deep dermis. In superficial dermis, elastin volume density was higher in normal skin compared with normal scars, hypertrophic scars, and keloids. In deep dermis, the elastin volume density was higher in keloids compared with normal skins, normal scars, and hypertrophic scars. We showed that the distribution of fibrillin‐1 and elastin is disrupted in all kinds of scars analyzed, but there are two patterns: one for normal scars and another for excessive scars.
Bibliography:istex:9502D480F1D5CFF80D42E45DE3C3ACEAC9C8B1BB
ark:/67375/WNG-V0RLDR8R-5
ArticleID:WRR12209
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1067-1927
1524-475X
DOI:10.1111/j.1067-1927.2004.012209.x