Surgical management of peritoneal metastasis: Opportunities for pharmaceutical research

Cytoreductive surgery (CRS) has emerged as a survival-extending treatment of peritoneal metastasis (PM); recent advances include using intraperitoneal chemotherapy (IPC) at normothermic or hyperthermic temperatures, or under pressure (CRS + IPC). Clinical CRS + IPC research has established its highl...

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Bibliographic Details
Published in:	Journal of controlled release Vol. 361; pp. 717 - 726
Main Authors:	Wientjes, Michael G., Lu, Ze, Chan, Carlos H.F., Turaga, Kiran, Au, Jessie L.S.
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 01.09.2023
Subjects:	Antineoplastic Combined Chemotherapy Protocols ascites Ascites - drug therapy Colorectal Neoplasms - drug therapy Combined Modality Therapy Cytoreductive surgery dialysis Drug binding to ascites proteins drug therapy drugs fever glycoproteins human serum albumin Humans Hyperthermia, Induced Hyperthermic intraperitoneal chemotherapy Intraperitoneal chemotherapy medicinal properties metastasis neoplasms Paclitaxel Paclitaxel - therapeutic use patients Peritoneal carcinomatosis Peritoneal Neoplasms - drug therapy Peritoneal Neoplasms - secondary Pharmaceutical Preparations Pharmaceutical Research pharmacodynamics pharmacokinetics protein binding Proteomics surgery Tandem Mass Spectrometry MCW CRS KHSA and KAAG Cbound and Cfree fu P PIPAC HIPEC UI Intraperitoneal chemotherapy Peritoneal carcinomatosis Paclitaxel HSA PBS R2 Cytoreductive surgery AAG IP Drug binding to ascites proteins ICD fb,measured fb,expected Hyperthermic intraperitoneal chemotherapy fb IPC PM
ISSN:	0168-3659, 1873-4995, 1873-4995
Online Access:	Get full text
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