Heat shock protein 60 levels in tissue and circulating exosomes in human large bowel cancer before and after ablative surgery

BACKGROUND Heat shock protein 60 (Hsp60) is a chaperonin involved in tumorigenesis, but its participation in tumor development and progression is not well understood and its value as a tumor biomarker has not been fully elucidated. In the current study, the authors presented evidence supporting the...

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Vydáno v:	Cancer Ročník 121; číslo 18; s. 3230 - 3239
Hlavní autoři:	Campanella, Claudia, Rappa, Francesca, Sciumè, Carmelo, Marino Gammazza, Antonella, Barone, Rosario, Bucchieri, Fabio, David, Sabrina, Curcurù, Giuseppe, Caruso Bavisotto, Celeste, Pitruzzella, Alessandro, Geraci, Girolamo, Modica, Giuseppe, Farina, Felicia, Zummo, Giovanni, Fais, Stefano, Conway de Macario, Everly, Macario, Alberto J.L., Cappello, Francesco
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 15.09.2015
Témata:	Adenocarcinoma - metabolism Adenocarcinoma - pathology Adenocarcinoma - surgery Aged Aged, 80 and over Biomarkers, Tumor - analysis Blotting, Western Chaperonin 60 - analysis Chaperonin 60 - metabolism colon adenocarcinoma Colonic Neoplasms - metabolism Colonic Neoplasms - pathology Colonic Neoplasms - surgery Enzyme-Linked Immunosorbent Assay exosomes Exosomes - metabolism Female heat shock protein 60 (Hsp60) Humans Immunohistochemistry macrophages Male Middle Aged Mitochondrial Proteins - analysis Mitochondrial Proteins - metabolism natural killer cells plasma cell membrane Real-Time Polymerase Chain Reaction theranostics heat shock protein 60 (Hsp60) plasma cell membrane natural killer cells macrophages colon adenocarcinoma exosomes theranostics
ISSN:	0008-543X, 1097-0142
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Abstract	BACKGROUND Heat shock protein 60 (Hsp60) is a chaperonin involved in tumorigenesis, but its participation in tumor development and progression is not well understood and its value as a tumor biomarker has not been fully elucidated. In the current study, the authors presented evidence supporting the theory that Hsp60 has potential as a biomarker as well as a therapeutic target in patients with large bowel cancer. METHODS The authors studied a population of 97 subjects, including patients and controls. Immunomorphology, Western blot analysis, and quantitative real‐time polymerase chain reaction were performed on tissue specimens. Exosomes were isolated from blood and characterized by electron microscopy, biochemical tests, and Western blot analysis. RESULTS Hsp60 was found to be increased in cancerous tissue, in which it was localized in the tumor cell plasma membrane, and in the interstitium associated with cells of the immune system, in which it was associated with exosomes liberated by tumor cells and, as such, circulated in the blood. An interesting finding was that these parameters returned to normal shortly after tumor removal. CONCLUSIONS The data from the current study suggested that Hsp60 is a good candidate for theranostics applied to patients with large bowel carcinoma and encourage similar research among patients with other tumors in which Hsp60 has been implicated. Cancer 2015;121:3230–3239. © 2015 American Cancer Society. Heat shock protein 60 is a chaperonin involved in tumorigenesis but its participation in tumor development and progression is not well understood and its value as a tumor biomarker has not been fully elucidated. In the current study, the authors present evidence supporting the theory that heat shock protein 60 has potential as a biomarker as well as a therapeutic target in patients with colon cancer.
AbstractList	Heat shock protein 60 is a chaperonin involved in tumorigenesis but its participation in tumor development and progression is not well understood and its value as a tumor biomarker has not been fully elucidated. In the current study, the authors present evidence supporting the theory that heat shock protein 60 has potential as a biomarker as well as a therapeutic target in patients with colon cancer. BACKGROUNDHeat shock protein 60 (Hsp60) is a chaperonin involved in tumorigenesis, but its participation in tumor development and progression is not well understood and its value as a tumor biomarker has not been fully elucidated. In the current study, the authors presented evidence supporting the theory that Hsp60 has potential as a biomarker as well as a therapeutic target in patients with large bowel cancer.METHODSThe authors studied a population of 97 subjects, including patients and controls. Immunomorphology, Western blot analysis, and quantitative real-time polymerase chain reaction were performed on tissue specimens. Exosomes were isolated from blood and characterized by electron microscopy, biochemical tests, and Western blot analysis.RESULTSHsp60 was found to be increased in cancerous tissue, in which it was localized in the tumor cell plasma membrane, and in the interstitium associated with cells of the immune system, in which it was associated with exosomes liberated by tumor cells and, as such, circulated in the blood. An interesting finding was that these parameters returned to normal shortly after tumor removal.CONCLUSIONSThe data from the current study suggested that Hsp60 is a good candidate for theranostics applied to patients with large bowel carcinoma and encourage similar research among patients with other tumors in which Hsp60 has been implicated. BACKGROUND Heat shock protein 60 (Hsp60) is a chaperonin involved in tumorigenesis, but its participation in tumor development and progression is not well understood and its value as a tumor biomarker has not been fully elucidated. In the current study, the authors presented evidence supporting the theory that Hsp60 has potential as a biomarker as well as a therapeutic target in patients with large bowel cancer. METHODS The authors studied a population of 97 subjects, including patients and controls. Immunomorphology, Western blot analysis, and quantitative real‐time polymerase chain reaction were performed on tissue specimens. Exosomes were isolated from blood and characterized by electron microscopy, biochemical tests, and Western blot analysis. RESULTS Hsp60 was found to be increased in cancerous tissue, in which it was localized in the tumor cell plasma membrane, and in the interstitium associated with cells of the immune system, in which it was associated with exosomes liberated by tumor cells and, as such, circulated in the blood. An interesting finding was that these parameters returned to normal shortly after tumor removal. CONCLUSIONS The data from the current study suggested that Hsp60 is a good candidate for theranostics applied to patients with large bowel carcinoma and encourage similar research among patients with other tumors in which Hsp60 has been implicated. Cancer 2015;121:3230–3239. © 2015 American Cancer Society. Heat shock protein 60 is a chaperonin involved in tumorigenesis but its participation in tumor development and progression is not well understood and its value as a tumor biomarker has not been fully elucidated. In the current study, the authors present evidence supporting the theory that heat shock protein 60 has potential as a biomarker as well as a therapeutic target in patients with colon cancer. Heat shock protein 60 (Hsp60) is a chaperonin involved in tumorigenesis, but its participation in tumor development and progression is not well understood and its value as a tumor biomarker has not been fully elucidated. In the current study, the authors presented evidence supporting the theory that Hsp60 has potential as a biomarker as well as a therapeutic target in patients with large bowel cancer. The authors studied a population of 97 subjects, including patients and controls. Immunomorphology, Western blot analysis, and quantitative real-time polymerase chain reaction were performed on tissue specimens. Exosomes were isolated from blood and characterized by electron microscopy, biochemical tests, and Western blot analysis. Hsp60 was found to be increased in cancerous tissue, in which it was localized in the tumor cell plasma membrane, and in the interstitium associated with cells of the immune system, in which it was associated with exosomes liberated by tumor cells and, as such, circulated in the blood. An interesting finding was that these parameters returned to normal shortly after tumor removal. The data from the current study suggested that Hsp60 is a good candidate for theranostics applied to patients with large bowel carcinoma and encourage similar research among patients with other tumors in which Hsp60 has been implicated.
Author	Modica, Giuseppe Rappa, Francesca Zummo, Giovanni Geraci, Girolamo Campanella, Claudia Barone, Rosario Fais, Stefano Sciumè, Carmelo David, Sabrina Conway de Macario, Everly Curcurù, Giuseppe Macario, Alberto J.L. Cappello, Francesco Caruso Bavisotto, Celeste Farina, Felicia Pitruzzella, Alessandro Marino Gammazza, Antonella Bucchieri, Fabio
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Keywords	heat shock protein 60 (Hsp60) plasma cell membrane natural killer cells macrophages colon adenocarcinoma exosomes theranostics
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Notes	The first 3 authors contributed equally to this work. We thank Claudio Tripodo, MD, for the gift of anti‐CD57 antibody. ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
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Snippet	BACKGROUND Heat shock protein 60 (Hsp60) is a chaperonin involved in tumorigenesis, but its participation in tumor development and progression is not well... Heat shock protein 60 is a chaperonin involved in tumorigenesis but its participation in tumor development and progression is not well understood and its value... Heat shock protein 60 (Hsp60) is a chaperonin involved in tumorigenesis, but its participation in tumor development and progression is not well understood and... BACKGROUNDHeat shock protein 60 (Hsp60) is a chaperonin involved in tumorigenesis, but its participation in tumor development and progression is not well...
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SubjectTerms	Adenocarcinoma - metabolism Adenocarcinoma - pathology Adenocarcinoma - surgery Aged Aged, 80 and over Biomarkers, Tumor - analysis Blotting, Western Chaperonin 60 - analysis Chaperonin 60 - metabolism colon adenocarcinoma Colonic Neoplasms - metabolism Colonic Neoplasms - pathology Colonic Neoplasms - surgery Enzyme-Linked Immunosorbent Assay exosomes Exosomes - metabolism Female heat shock protein 60 (Hsp60) Humans Immunohistochemistry macrophages Male Middle Aged Mitochondrial Proteins - analysis Mitochondrial Proteins - metabolism natural killer cells plasma cell membrane Real-Time Polymerase Chain Reaction theranostics
Title	Heat shock protein 60 levels in tissue and circulating exosomes in human large bowel cancer before and after ablative surgery
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