Myocardial T1 mapping at 3.0 tesla using an inversion recovery spoiled gradient echo readout and bloch equation simulation with slice profile correction (BLESSPC) T1 estimation algorithm

Background To develop an accurate and precise myocardial T1 mapping technique using an inversion recovery spoiled gradient echo readout at 3.0 Tesla (T). Theory and Methods The modified Look‐Locker inversion‐recovery (MOLLI) sequence was modified to use fast low angle shot (FLASH) readout, incorpora...

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Veröffentlicht in:Journal of magnetic resonance imaging Jg. 43; H. 2; S. 414 - 425
Hauptverfasser: Shao, Jiaxin, Rapacchi, Stanislas, Nguyen, Kim-Lien, Hu, Peng
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States Blackwell Publishing Ltd 01.02.2016
Wiley Subscription Services, Inc
Schlagworte:
Adult
Female
Heart - anatomy & histology
high field T1 mapping
Humans
Image Interpretation, Computer-Assisted - methods
Magnetic resonance imaging
Magnetic Resonance Imaging - methods
Male
MOLLI
MR relaxometry
Phantoms, Imaging
quantitative cardiac MRI
Reference Values
Reproducibility of Results
MR relaxometry
high field T1 mapping
quantitative cardiac MRI
MOLLI
ISSN:1053-1807, 1522-2586, 1522-2586
Online-Zugang:Volltext
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Zusammenfassung:Background To develop an accurate and precise myocardial T1 mapping technique using an inversion recovery spoiled gradient echo readout at 3.0 Tesla (T). Theory and Methods The modified Look‐Locker inversion‐recovery (MOLLI) sequence was modified to use fast low angle shot (FLASH) readout, incorporating a BLESSPC (Bloch Equation Simulation with Slice Profile Correction) T1 estimation algorithm, for accurate myocardial T1 mapping. The FLASH‐MOLLI with BLESSPC fitting was compared with different approaches and sequences with regards to T1 estimation accuracy, precision and image artifact based on simulation, phantom studies, and in vivo studies of 10 healthy volunteers and three patients at 3.0 Tesla. Results The FLASH‐MOLLI with BLESSPC fitting yields accurate T1 estimation (average error = −5.4 ± 15.1 ms, percentage error = −0.5% ± 1.2%) for T1 from 236–1852 ms and heart rate from 40–100 bpm in phantom studies. The FLASH‐MOLLI sequence prevented off‐resonance artifacts in all 10 healthy volunteers at 3.0T. In vivo, there was no significant difference between FLASH‐MOLLI‐derived myocardial T1 values and “ShMOLLI+IE” derived values (1458.9 ± 20.9 ms versus 1464.1 ± 6.8 ms, P = 0.50); However, the average precision by FLASH‐MOLLI was significantly better than that generated by “ShMOLLI+IE” (1.84 ± 0.36% variance versus 3.57 ± 0.94%, P < 0.001). Conclusion The FLASH‐MOLLI with BLESSPC fitting yields accurate and precise T1 estimation, and eliminates banding artifacts associated with bSSFP at 3.0T. J. Magn. Reson. Imaging 2016;43:414–425.
Bibliographie:Siemens Medical Solutions.
National Institutes of Health - No. National Institutes of Health
istex:B156D4BEC4715AE5CBAA3F9CD893641A6EC4B0F4
National Institutes of Health and Siemens Medical Solutions
ArticleID:JMRI24999
ark:/67375/WNG-3JPZKWVJ-K
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:1053-1807
1522-2586
1522-2586
DOI:10.1002/jmri.24999