Predictable increase in female reproductive window: A simple model connecting age of reproduction, menopause, and longevity

With the ever‐increasing lifespan along with societal changes, women can marry and procreate later than in previous centuries. However, pathogenic genetic variants segregating in the population can lead to female subfertility or infertility well before the average age of normal menopause, leading to...

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Published in:BioEssays Vol. 43; no. 5; pp. e2000233 - n/a
Main Authors: Innan, Hideki, Vaiman, Daniel, Veitia, Reiner A.
Format: Journal Article
Language:English
Published: United States Wiley 01.05.2021
Wiley Subscription Services, Inc
Subjects:
age at menopause
Alleles
DNA recombination
DNA repair
Epigenetics
Female
female fertility
female infertility
female subfertility
Females
Fertility
Genetic diversity
Genetic variance
Humans
Infertility
Life span
lifestyle
Longevity
Menopause
Model testing
Reproduction
female subfertility
DNA recombination
female infertility
DNA repair
age at menopause
ISSN:0265-9247, 1521-1878, 1521-1878
Online Access:Get full text
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Summary:With the ever‐increasing lifespan along with societal changes, women can marry and procreate later than in previous centuries. However, pathogenic genetic variants segregating in the population can lead to female subfertility or infertility well before the average age of normal menopause, leading to counter‐selection of such deleterious alleles. In reviewing this field, we speculate that a logical consequence would be the later occurrence of menopause and the extension of women's reproductive lifespan. We illustrate this point with a simple model that applies to other variants that contribute to female infertility, including epigenetic variation. We also consider the effect of medical interventions and lifestyle. Pathogenic genetic variants segregating in the population can lead to female subfertility or infertility well before the average age of normal menopause, leading to counter‐selection of such deleterious alleles. As women marry later than in previous centuries, we speculate that a logical consequence would be the later occurrence of menopause and the extension of their reproductive window.
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ISSN:0265-9247
1521-1878
1521-1878
DOI:10.1002/bies.202000233