Scorpion venom components as potential candidates for drug development

Scorpions are well known for their dangerous stings that can result in severe consequences for human beings, including death. Neurotoxins present in their venoms are responsible for their toxicity. Due to their medical relevance, toxins have been the driving force in the scorpion natural compounds r...

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Vydané v:Toxicon (Oxford) Ročník 93; s. 125 - 135
Hlavní autori: Ortiz, Ernesto, Gurrola, Georgina B., Schwartz, Elisabeth Ferroni, Possani, Lourival D.
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: England Elsevier Ltd 01.01.2015
Predmet:
Africa
Angiotensin-Converting Enzyme Inhibitors - isolation & purification
Anti-Infective Agents - isolation & purification
antibiotics
Anticancer peptides
Antimicrobial Cationic Peptides
Antimicrobials
antineoplastic agents
Antineoplastic Agents - isolation & purification
Asia
Biological Products - analysis
Biological Products - isolation & purification
Biological Products - pharmacology
bites and stings
Bradykinin-potentiating peptides
death
Drug candidates
Drug Discovery - methods
Humans
Immune-modulators
Immunologic Factors - isolation & purification
neurotoxins
Potassium Channel Blockers - immunology
Potassium Channel Blockers - isolation & purification
Scorpion venom
Scorpion Venoms - chemistry
Scorpiones
toxicity
traditional medicine
venoms
Asia
Africa
Anticancer peptides
Bradykinin-potentiating peptides
Immune-modulators
Antimicrobials
Scorpion venom
Drug candidates
ISSN:0041-0101, 1879-3150, 1879-3150
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Shrnutí:Scorpions are well known for their dangerous stings that can result in severe consequences for human beings, including death. Neurotoxins present in their venoms are responsible for their toxicity. Due to their medical relevance, toxins have been the driving force in the scorpion natural compounds research field. On the other hand, for thousands of years, scorpions and their venoms have been applied in traditional medicine, mainly in Asia and Africa. With the remarkable growth in the number of characterized scorpion venom components, several drug candidates have been found with the potential to tackle many of the emerging global medical threats. Scorpions have become a valuable source of biologically active molecules, from novel antibiotics to potential anticancer therapeutics. Other venom components have drawn attention as useful scaffolds for the development of drugs. This review summarizes the most promising candidates for drug development that have been isolated from scorpion venoms.
Bibliografia:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
content type line 23
ISSN:0041-0101
1879-3150
1879-3150
DOI:10.1016/j.toxicon.2014.11.233