Preexisting High Expression of Matrix Metalloproteinase-2 in Tunica Media of Saphenous Vein Conduits Is Associated with Unfavorable Long-Term Outcomes after Coronary Artery Bypass Grafting

Migration of the smooth muscle cells (SMCs) to the tunica media in the saphenous vein (SV) transplants is facilitated by matrix metalloproteinases (MMPs). The aim of this study was to identify any associations between expression of MMP-2 or endogenous tissue inhibitors (TIMP-2 and TIMP-3) in the SV...

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Vydané v:	BioMed research international Ročník 2013; číslo 2013; s. 1 - 9
Hlavní autori:	Nowicki, Michał, Zabel, Maciej, Ostalska-Nowicka, Danuta, Misterski, Marcin, Malinska, Agnieszka, Perek, Bartlomiej, Perek, Anna
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	Cairo, Egypt Hindawi Publishing Corporation 01.01.2013 John Wiley & Sons, Inc
Predmet:	Adult Aged Aged, 80 and over Aging Atherosclerosis Cardiovascular disease Colleges & universities Coronary Artery Bypass - adverse effects Coronary Artery Bypass - methods Coronary vessels Diabetes Female Gene Expression Regulation Heart attacks Heart surgery Humans Hypertension Male Matrix Metalloproteinase 2 - biosynthesis Matrix Metalloproteinase 2 - metabolism Medical imaging Middle Aged Multivariate analysis Myocytes, Smooth Muscle - metabolism Saphenous Vein - metabolism Saphenous Vein - pathology Smoking Tissue Inhibitor of Metalloproteinase-2 - biosynthesis Tissue Inhibitor of Metalloproteinase-3 - biosynthesis Treatment Outcome Tunica Media - metabolism Tunica Media - pathology
ISSN:	2314-6133, 2314-6141, 2314-6141
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