Occasional spontaneous clearance of chronic hepatitis C virus in HIV-infected individuals

The IL28B genotype has been found to have a strong influence on spontaneous clearance of acute HCV both in HCV mono- and HIV/ the HCV co-infected patients. Spontaneous clearance of chronic HCV without HCV treatment is rare. Here, we report on three chronic HCV cases co-infected with HIV with spontan...

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Bibliographic Details
Published in:Journal of hepatology Vol. 61; no. 4; pp. 957 - 961
Main Authors: Stenkvist, Jenny, Nyström, Jessica, Falconer, Karolin, Sönnerborg, Anders, Weiland, Ola
Format: Journal Article
Language:English
Published: Netherlands Elsevier B.V 01.10.2014
Subjects:
Anti-Retroviral Agents - therapeutic use
CD4 Lymphocyte Count - methods
Coinfection
Female
Gastroenterology and Hepatology
Genetic Association Studies
HCV
Hepacivirus - genetics
Hepatitis C, Chronic - diagnosis
Hepatitis C, Chronic - epidemiology
Hepatitis C, Chronic - genetics
Hepatitis C, Chronic - physiopathology
Hepatitis C, Chronic - virology
HIV
HIV Infections - drug therapy
HIV Infections - epidemiology
HIV Infections - genetics
HIV Infections - immunology
HIV/HCV co-infection
Humans
IL28B
Interferons
Interleukins - genetics
Male
Middle Aged
Polymorphism, Single Nucleotide
Remission, Spontaneous
Retrospective Studies
RNA, Viral - blood
Serologic Tests - methods
Sweden
Viral Load - methods
Sweden
peg-IFN
AST
ART
MSM
PWID
ALT
HIV/HCV co-infection
IL28B
HIV
SNP
ULN
HCV
IDU
HBV
single nucleotide polymorphism
hepatitis B virus
pegylated interferon
antiretroviral treatment
men who have sex with men
alanine transaminase
people who inject drugs
hepatitis C virus
interleukin 28B
upper limit of normal
human immunodeficiency virus
intravenous drug use
aspartate transaminase
ISSN:0168-8278, 1600-0641, 1600-0641
Online Access:Get full text
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Summary:The IL28B genotype has been found to have a strong influence on spontaneous clearance of acute HCV both in HCV mono- and HIV/ the HCV co-infected patients. Spontaneous clearance of chronic HCV without HCV treatment is rare. Here, we report on three chronic HCV cases co-infected with HIV with spontaneous clearance of their HCV infection, all with the IL28B CC genotype. These cases were derived from a surveillance of the total HIV/HCV co-infected cohort in Sweden (n=466). The estimated frequency of spontaneous clearance of chronic HCV infection in our cohort was calculated to be 0.6–4.7%. Our cases lend some support to the initiation of ART prior to HCV treatment in HIV/HCV co-infected patients. Furthermore, HCV-RNA testing should be recommended immediately before initiation of HCV treatment, to find the subset of HIV/HCV co-infected patients with IL28B CC that may have cleared their chronic infection spontaneously.
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ISSN:0168-8278
1600-0641
1600-0641
DOI:10.1016/j.jhep.2014.06.014