Occasional spontaneous clearance of chronic hepatitis C virus in HIV-infected individuals

The IL28B genotype has been found to have a strong influence on spontaneous clearance of acute HCV both in HCV mono- and HIV/ the HCV co-infected patients. Spontaneous clearance of chronic HCV without HCV treatment is rare. Here, we report on three chronic HCV cases co-infected with HIV with spontan...

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Veröffentlicht in:	Journal of hepatology Jg. 61; H. 4; S. 957 - 961
Hauptverfasser:	Stenkvist, Jenny, Nyström, Jessica, Falconer, Karolin, Sönnerborg, Anders, Weiland, Ola
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Netherlands Elsevier B.V 01.10.2014
Schlagworte:	Anti-Retroviral Agents - therapeutic use CD4 Lymphocyte Count - methods Coinfection Female Gastroenterology and Hepatology Genetic Association Studies HCV Hepacivirus - genetics Hepatitis C, Chronic - diagnosis Hepatitis C, Chronic - epidemiology Hepatitis C, Chronic - genetics Hepatitis C, Chronic - physiopathology Hepatitis C, Chronic - virology HIV HIV Infections - drug therapy HIV Infections - epidemiology HIV Infections - genetics HIV Infections - immunology HIV/HCV co-infection Humans IL28B Interferons Interleukins - genetics Male Middle Aged Polymorphism, Single Nucleotide Remission, Spontaneous Retrospective Studies RNA, Viral - blood Serologic Tests - methods Sweden Viral Load - methods Sweden peg-IFN AST ART MSM PWID ALT HIV/HCV co-infection IL28B HIV SNP ULN HCV IDU HBV single nucleotide polymorphism hepatitis B virus pegylated interferon antiretroviral treatment men who have sex with men alanine transaminase people who inject drugs hepatitis C virus interleukin 28B upper limit of normal human immunodeficiency virus intravenous drug use aspartate transaminase
ISSN:	0168-8278, 1600-0641, 1600-0641
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Zusammenfassung:	The IL28B genotype has been found to have a strong influence on spontaneous clearance of acute HCV both in HCV mono- and HIV/ the HCV co-infected patients. Spontaneous clearance of chronic HCV without HCV treatment is rare. Here, we report on three chronic HCV cases co-infected with HIV with spontaneous clearance of their HCV infection, all with the IL28B CC genotype. These cases were derived from a surveillance of the total HIV/HCV co-infected cohort in Sweden (n=466). The estimated frequency of spontaneous clearance of chronic HCV infection in our cohort was calculated to be 0.6–4.7%. Our cases lend some support to the initiation of ART prior to HCV treatment in HIV/HCV co-infected patients. Furthermore, HCV-RNA testing should be recommended immediately before initiation of HCV treatment, to find the subset of HIV/HCV co-infected patients with IL28B CC that may have cleared their chronic infection spontaneously.
Bibliographie:	ObjectType-Case Study-2 SourceType-Scholarly Journals-1 ObjectType-Feature-4 content type line 23 ObjectType-Report-1 ObjectType-Article-3
ISSN:	0168-8278 1600-0641 1600-0641
DOI:	10.1016/j.jhep.2014.06.014