Changes in cerebral oxygenation and cerebral blood flow during hemodialysis - A simultaneous near-infrared spectroscopy and positron emission tomography study

Near-infrared spectroscopy (NIRS) is used to monitor cerebral tissue oxygenation (rSO ) depending on cerebral blood flow (CBF), cerebral blood volume and blood oxygen content. We explored whether NIRS might be a more easy applicable proxy to [ O]H O positron emission tomography (PET) for detecting C...

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Vydáno v:Journal of cerebral blood flow and metabolism Ročník 40; číslo 2; s. 328
Hlavní autoři: Polinder-Bos, Harmke A, Elting, Jan Willem J, Aries, Marcel Jh, García, David Vállez, Willemsen, Antoon Tm, van Laar, Peter J, Kuipers, Johanna, Krijnen, Wim P, Slart, Riemer Hja, Luurtsema, Gert, Westerhuis, Ralf, Gansevoort, Ron T, Gaillard, Carlo Ajm, Franssen, Casper Fm
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States 01.02.2020
Témata:
Aged
Aged, 80 and over
Brain - blood supply
Brain - diagnostic imaging
Brain - metabolism
Cerebrovascular Circulation
Female
Humans
Male
Oximetry
Oxygen - blood
Positron-Emission Tomography
Renal Dialysis
Spectroscopy, Near-Infrared
cerebral oximetry
NIRS
hemodialysis
water-PET
Brain perfusion
ISSN:1559-7016, 1559-7016
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Shrnutí:Near-infrared spectroscopy (NIRS) is used to monitor cerebral tissue oxygenation (rSO ) depending on cerebral blood flow (CBF), cerebral blood volume and blood oxygen content. We explored whether NIRS might be a more easy applicable proxy to [ O]H O positron emission tomography (PET) for detecting CBF changes during hemodialysis. Furthermore, we compared potential determinants of rSO and CBF. In 12 patients aged ≥ 65 years, NIRS and PET were performed simultaneously: before (T1), early after start (T2), and at the end of hemodialysis (T3). Between T1 and T3, the relative change in frontal rSO (ΔrSO ) was -8 ± 9% (  = 0.001) and -5 ± 11% (  = 0.08), whereas the relative change in frontal gray matter CBF (ΔCBF) was -11 ± 18% (  = 0.009) and -12 ± 16% (  = 0.007) for the left and right hemisphere, respectively. ΔrSO and ΔCBF were weakly correlated for the left (ρ 0.31,  = 0.4), and moderately correlated for the right (ρ 0.69,  = 0.03) hemisphere. The Bland-Altman plot suggested underestimation of ΔCBF by NIRS. Divergent associations of pH, pCO and arterial oxygen content with rSO were found compared to corresponding associations with CBF. In conclusion, NIRS could be a proxy to PET to detect intradialytic CBF changes, although NIRS and PET capture different physiological parameters of the brain.
Bibliografie:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ISSN:1559-7016
1559-7016
DOI:10.1177/0271678X18818652