RNA Secondary Structure as a First Step for Rational Design of the Oligonucleotides towards Inhibition of Influenza A Virus Replication

Influenza is an important research subject around the world because of its threat to humanity. Influenza A virus (IAV) causes seasonal epidemics and sporadic, but dangerous pandemics. A rapid antigen changes and recombination of the viral RNA genome contribute to the reduced effectiveness of vaccina...

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Bibliographic Details
Published in:	Pathogens (Basel) Vol. 9; no. 11; p. 925
Main Authors:	Szabat, Marta, Lorent, Dagny, Czapik, Tomasz, Tomaszewska, Maria, Kierzek, Elzbieta, Kierzek, Ryszard
Format:	Journal Article
Language:	English
Published:	Basel MDPI AG 07.11.2020 MDPI
Subjects:	Acids Antigens Antisense oligonucleotides Antisense therapy Antiviral agents antiviral strategies Design Drug development Drugs dynamics Gene expression genome Genomes Glycoproteins Influenza Influenza A Influenza A virus information Life cycles Ligands microRNA MicroRNAs miRNA Mutation Nucleic acids Oligonucleotides Packaging pandemic Pandemics pathogens prediction Protein structure Proteins Recombination Replication Review Ribonucleic acid ribonucleoproteins RNA RNA interference RNA structure RNA viruses Secondary structure Segments siRNA small interfering RNA structure-activity relationships Structure-function relationships Therapeutic targets Transcription Vaccination Viral infections virion Virions virus replication Viruses
ISSN:	2076-0817, 2076-0817
Online Access:	Get full text
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