RNA Secondary Structure as a First Step for Rational Design of the Oligonucleotides towards Inhibition of Influenza A Virus Replication

Influenza is an important research subject around the world because of its threat to humanity. Influenza A virus (IAV) causes seasonal epidemics and sporadic, but dangerous pandemics. A rapid antigen changes and recombination of the viral RNA genome contribute to the reduced effectiveness of vaccina...

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Veröffentlicht in:Pathogens (Basel) Jg. 9; H. 11; S. 925
Hauptverfasser: Szabat, Marta, Lorent, Dagny, Czapik, Tomasz, Tomaszewska, Maria, Kierzek, Elzbieta, Kierzek, Ryszard
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Basel MDPI AG 07.11.2020
MDPI
Schlagworte:
Acids
Antigens
Antisense oligonucleotides
Antisense therapy
Antiviral agents
antiviral strategies
Design
Drug development
Drugs
dynamics
Gene expression
genome
Genomes
Glycoproteins
Influenza
Influenza A
Influenza A virus
information
Life cycles
Ligands
microRNA
MicroRNAs
miRNA
Mutation
Nucleic acids
Oligonucleotides
Packaging
pandemic
Pandemics
pathogens
prediction
Protein structure
Proteins
Recombination
Replication
Review
Ribonucleic acid
ribonucleoproteins
RNA
RNA interference
RNA structure
RNA viruses
Secondary structure
Segments
siRNA
small interfering RNA
structure-activity relationships
Structure-function relationships
Therapeutic targets
Transcription
Vaccination
Viral infections
virion
Virions
virus replication
Viruses
ISSN:2076-0817, 2076-0817
Online-Zugang:Volltext
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Zusammenfassung:Influenza is an important research subject around the world because of its threat to humanity. Influenza A virus (IAV) causes seasonal epidemics and sporadic, but dangerous pandemics. A rapid antigen changes and recombination of the viral RNA genome contribute to the reduced effectiveness of vaccination and anti-influenza drugs. Hence, there is a necessity to develop new antiviral drugs and strategies to limit the influenza spread. IAV is a single-stranded negative sense RNA virus with a genome (viral RNA—vRNA) consisting of eight segments. Segments within influenza virion are assembled into viral ribonucleoprotein (vRNP) complexes that are independent transcription-replication units. Each step in the influenza life cycle is regulated by the RNA and is dependent on its interplay and dynamics. Therefore, viral RNA can be a proper target to design novel therapeutics. Here, we briefly described examples of anti-influenza strategies based on the antisense oligonucleotide (ASO), small interfering RNA (siRNA), microRNA (miRNA) and catalytic nucleic acids. In particular we focused on the vRNA structure-function relationship as well as presented the advantages of using secondary structure information in predicting therapeutic targets and the potential future of this field.
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ISSN:2076-0817
2076-0817
DOI:10.3390/pathogens9110925