C-reactive protein induces expression of matrix metalloproteinase-9: A possible link between inflammation and plaque rupture

Matrix metalloproteases (MMPs) have been implicated in the pathogenesis of acute coronary syndromes (ACS). However, little is known about the mechanisms responsible for MMP expression in ACS. C-reactive protein (CRP) not only is an independent risk factor for cardiovascular events, but also may exer...

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Bibliographic Details
Published in:	International journal of cardiology Vol. 168; no. 2; pp. 981 - 986
Main Authors:	Cimmino, Giovanni, Ragni, Massimo, Cirillo, Plinio, Petrillo, Gianluca, Loffredo, Francesco, Chiariello, Massimo, Gresele, Paolo, Falcinelli, Emanuela, Golino, Paolo
Format:	Journal Article
Language:	English
Published:	Shannon Elsevier Ireland Ltd 30.09.2013 Elsevier
Subjects:	Acute Coronary Syndrome - enzymology Acute Coronary Syndrome - genetics Acute Coronary Syndrome - metabolism Acute coronary syndromes Aged Biological and medical sciences C-Reactive Protein - metabolism C-Reactive Protein - physiology Cardiology. Vascular system Cardiovascular Cells, Cultured Coronary heart disease CRP Female Gene Expression Regulation, Enzymologic Heart Humans Inflammation - enzymology Inflammation - genetics Inflammation - metabolism Male Matrix Metalloproteinase 9 - biosynthesis Matrix Metalloproteinase 9 - genetics Medical sciences Middle Aged MMP-9 Muscle, Smooth, Vascular - enzymology Muscle, Smooth, Vascular - metabolism Myocarditis. Cardiomyopathies Myocytes, Smooth Muscle - enzymology Myocytes, Smooth Muscle - pathology Plaque, Atherosclerotic - blood Plaque, Atherosclerotic - enzymology Plaque, Atherosclerotic - metabolism Up-Regulation - genetics CRP Acute coronary syndromes MMP-9 Enzyme Rupture Metalloendopeptidases Cardiovascular disease Inflammation Gene expression Coronary heart disease Myocardial disease Gelatinase B Peptidases Acute phase protein Hydrolases Cardiology C reactive protein Acute coronary syndrome
ISSN:	0167-5273, 1874-1754, 1874-1754
Online Access:	Get full text
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