C-reactive protein induces expression of matrix metalloproteinase-9: A possible link between inflammation and plaque rupture

Matrix metalloproteases (MMPs) have been implicated in the pathogenesis of acute coronary syndromes (ACS). However, little is known about the mechanisms responsible for MMP expression in ACS. C-reactive protein (CRP) not only is an independent risk factor for cardiovascular events, but also may exer...

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Vydáno v:	International journal of cardiology Ročník 168; číslo 2; s. 981 - 986
Hlavní autoři:	Cimmino, Giovanni, Ragni, Massimo, Cirillo, Plinio, Petrillo, Gianluca, Loffredo, Francesco, Chiariello, Massimo, Gresele, Paolo, Falcinelli, Emanuela, Golino, Paolo
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Shannon Elsevier Ireland Ltd 30.09.2013 Elsevier
Témata:	Acute Coronary Syndrome - enzymology Acute Coronary Syndrome - genetics Acute Coronary Syndrome - metabolism Acute coronary syndromes Aged Biological and medical sciences C-Reactive Protein - metabolism C-Reactive Protein - physiology Cardiology. Vascular system Cardiovascular Cells, Cultured Coronary heart disease CRP Female Gene Expression Regulation, Enzymologic Heart Humans Inflammation - enzymology Inflammation - genetics Inflammation - metabolism Male Matrix Metalloproteinase 9 - biosynthesis Matrix Metalloproteinase 9 - genetics Medical sciences Middle Aged MMP-9 Muscle, Smooth, Vascular - enzymology Muscle, Smooth, Vascular - metabolism Myocarditis. Cardiomyopathies Myocytes, Smooth Muscle - enzymology Myocytes, Smooth Muscle - pathology Plaque, Atherosclerotic - blood Plaque, Atherosclerotic - enzymology Plaque, Atherosclerotic - metabolism Up-Regulation - genetics CRP Acute coronary syndromes MMP-9 Enzyme Rupture Metalloendopeptidases Cardiovascular disease Inflammation Gene expression Coronary heart disease Myocardial disease Gelatinase B Peptidases Acute phase protein Hydrolases Cardiology C reactive protein Acute coronary syndrome
ISSN:	0167-5273, 1874-1754, 1874-1754
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