Frequent concomitant inactivation of miR-34a and miR-34b/c by CpG methylation in colorectal, pancreatic, mammary, ovarian, urothelial, and renal cell carcinomas and soft tissue sarcomas

The microRNA encoding genes miR-34a and miR-34b/c represent direct p53 target genes and possess tumor suppressive properties as they mediate apoptosis, cell cycle arrest, and senescence. We previously reported that the miR-34a gene is subject to epigenetic inactivation by CpG methylation of its prom...

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Bibliographic Details
Published in:	Virchows Archiv : an international journal of pathology Vol. 458; no. 3; pp. 313 - 322
Main Authors:	Vogt, Markus, Munding, Johanna, Grüner, Martha, Liffers, Sven-Thorsten, Verdoodt, Berlinda, Hauk, Jennifer, Steinstraesser, Lars, Tannapfel, Andrea, Hermeking, Heiko
Format:	Journal Article
Language:	English
Published:	Berlin/Heidelberg Springer-Verlag 01.03.2011 Springer Springer Nature B.V
Subjects:	Apoptosis Biological and medical sciences Breast Neoplasms - genetics Cell Line, Tumor Colorectal carcinoma Colorectal Neoplasms - genetics CpG Islands - genetics DNA Methylation DNA, Neoplasm - genetics Female Female genital diseases Gene Expression Regulation, Neoplastic Gene Silencing Genome Gynecology. Andrology. Obstetrics Humans Immunoenzyme Techniques Inactivation Investigative techniques, diagnostic techniques (general aspects) Kidney Neoplasms - genetics Kidneys Male Medical sciences Medicine Medicine & Public Health Methylation MicroRNAs - genetics Mutation Nephrology. Urinary tract diseases Original Article Ovarian cancer Ovarian Neoplasms - genetics Pancreatic cancer Pancreatic Neoplasms - genetics Pathology Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Prostate cancer Sarcoma Sarcoma - genetics Sarcoma - pathology Soft Tissue Neoplasms - genetics Soft Tissue Neoplasms - pathology Tumors Tumors of the urinary system Urologic Neoplasms - genetics CpG methylation family p53 Cancer Epigenetic inactivation Ovary carcinoma miR-34a Ovary cancer Transitional cell carcinoma Inactivation TP53 Gene GC rich sequence Family environment Grawitz tumor Colon Mammary gland Pancreas Tumor suppressor gene Kidney disease Urinary system disease miR-34 family Nucleotide sequence Digestive system Family study Gut Soft tissue sarcoma Malignant tumor Female genital diseases Ovarian diseases miR-34b/c Kidney cancer Rectum Breast Frequency Methylation
ISSN:	0945-6317, 1432-2307, 1432-2307
Online Access:	Get full text
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