Intravascular Mesenchymal Stromal/Stem Cell Therapy Product Diversification: Time for New Clinical Guidelines

Intravascular infusion is the most popular route for therapeutic multipotent mesenchymal stromal/stem cell (MSC) delivery in hundreds of clinical trials. Meta-analysis has demonstrated that bone marrow MSC infusion is safe. It is not clear if this also applies to diverse new cell products derived fr...

Full description

Saved in:
Bibliographic Details
Published in:Trends in molecular medicine Vol. 25; no. 2; pp. 149 - 163
Main Authors: Moll, Guido, Ankrum, James A., Kamhieh-Milz, Julian, Bieback, Karen, Ringdén, Olle, Volk, Hans-Dieter, Geissler, Sven, Reinke, Petra
Format: Journal Article
Language:English
Published: England Elsevier Ltd 01.02.2019
Subjects:
Animals
CD142
cellular therapy
Clinical Trials as Topic
hemocompatibility
Humans
Inflammation - etiology
Inflammation - immunology
Mesenchymal Stem Cell Transplantation - adverse effects
Mesenchymal Stem Cell Transplantation - methods
Mesenchymal Stem Cells - cytology
Mesenchymal Stem Cells - immunology
mesenchymal stromal/stem cell
safety and efficacy
Thromboplastin - analysis
Thromboplastin - immunology
tissue factor
tissue source
CD142
hemocompatibility
tissue factor
safety and efficacy
cellular therapy
mesenchymal stromal/stem cell
tissue source
ISSN:1471-4914, 1471-499X, 1471-499X
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Abstract Intravascular infusion is the most popular route for therapeutic multipotent mesenchymal stromal/stem cell (MSC) delivery in hundreds of clinical trials. Meta-analysis has demonstrated that bone marrow MSC infusion is safe. It is not clear if this also applies to diverse new cell products derived from other sources, such as adipose and perinatal tissues. Different MSC products display varying levels of highly procoagulant tissue factor (TF) and may adversely trigger the instant blood-mediated inflammatory reaction (IBMIR). Suitable strategies for assessing and controlling hemocompatibility and optimized cell delivery are crucial for the development of safer and more effective MSC therapies. MSC products have largely diversified during the past decade, making extrapolation about safety and efficacy from first-generation products inappropriate. MSCs and other blood non-resident cellular therapeutics display different degrees of incompatibility with human blood, which compromises their safety and efficacy. TF is the major determinant of cell product hemocompatibility, and this should be routinely monitored in all therapeutics intended for intravascular delivery. MSC products from different tissue sources display high variability in TF expression, with potential lethal consequences for patients when infused systemically. Once aware of the problem, a large array of product and process innovations became available to improve the clinical delivery of systemically infused cellular therapeutics.
AbstractList Intravascular infusion is the most popular route for therapeutic multipotent mesenchymal stromal/stem cell (MSC) delivery in hundreds of clinical trials. Meta-analysis has demonstrated that bone marrow MSC infusion is safe. It is not clear if this also applies to diverse new cell products derived from other sources, such as adipose and perinatal tissues. Different MSC products display varying levels of highly procoagulant tissue factor (TF) and may adversely trigger the instant blood-mediated inflammatory reaction (IBMIR). Suitable strategies for assessing and controlling hemocompatibility and optimized cell delivery are crucial for the development of safer and more effective MSC therapies. MSC products have largely diversified during the past decade, making extrapolation about safety and efficacy from first-generation products inappropriate. MSCs and other blood non-resident cellular therapeutics display different degrees of incompatibility with human blood, which compromises their safety and efficacy. TF is the major determinant of cell product hemocompatibility, and this should be routinely monitored in all therapeutics intended for intravascular delivery. MSC products from different tissue sources display high variability in TF expression, with potential lethal consequences for patients when infused systemically. Once aware of the problem, a large array of product and process innovations became available to improve the clinical delivery of systemically infused cellular therapeutics.
Intravascular infusion is the most popular route for therapeutic multipotent mesenchymal stromal/stem cell (MSC) delivery in hundreds of clinical trials. Meta-analysis has demonstrated that bone marrow MSC infusion is safe. It is not clear if this also applies to diverse new cell products derived from other sources, such as adipose and perinatal tissues. Different MSC products display varying levels of highly procoagulant tissue factor (TF) and may adversely trigger the instant blood-mediated inflammatory reaction (IBMIR). Suitable strategies for assessing and controlling hemocompatibility and optimized cell delivery are crucial for the development of safer and more effective MSC therapies.
Intravascular infusion is the most popular route for therapeutic multipotent mesenchymal stromal/stem cell (MSC) delivery in hundreds of clinical trials. Meta-analysis has demonstrated that bone marrow MSC infusion is safe. It is not clear if this also applies to diverse new cell products derived from other sources, such as adipose and perinatal tissues. Different MSC products display varying levels of highly procoagulant tissue factor (TF) and may adversely trigger the instant blood-mediated inflammatory reaction (IBMIR). Suitable strategies for assessing and controlling hemocompatibility and optimized cell delivery are crucial for the development of safer and more effective MSC therapies.Intravascular infusion is the most popular route for therapeutic multipotent mesenchymal stromal/stem cell (MSC) delivery in hundreds of clinical trials. Meta-analysis has demonstrated that bone marrow MSC infusion is safe. It is not clear if this also applies to diverse new cell products derived from other sources, such as adipose and perinatal tissues. Different MSC products display varying levels of highly procoagulant tissue factor (TF) and may adversely trigger the instant blood-mediated inflammatory reaction (IBMIR). Suitable strategies for assessing and controlling hemocompatibility and optimized cell delivery are crucial for the development of safer and more effective MSC therapies.
Author Reinke, Petra
Geissler, Sven
Ankrum, James A.
Moll, Guido
Kamhieh-Milz, Julian
Ringdén, Olle
Bieback, Karen
Volk, Hans-Dieter
Author_xml – sequence: 1
  givenname: Guido
  orcidid: 0000-0001-6173-5957
  surname: Moll
  fullname: Moll, Guido
  email: guido.moll@charite.de
  organization: Berlin-Brandenburg Center for Regenerative Therapies (BCRT), Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin (FUB), Humboldt-Universität zu Berlin (HUB), and Berlin Institute of Health (BIH), Berlin, Germany
– sequence: 2
  givenname: James A.
  surname: Ankrum
  fullname: Ankrum, James A.
  organization: Roy J. Carver Department of Biomedical Engineering, University of Iowa, Iowa City, IA, USA
– sequence: 3
  givenname: Julian
  surname: Kamhieh-Milz
  fullname: Kamhieh-Milz, Julian
  organization: Department of Transfusion Medicine, Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin (FUB), Humboldt-Universität zu Berlin (HUB), and Berlin Institute of Health (BIH), Berlin, Germany
– sequence: 4
  givenname: Karen
  surname: Bieback
  fullname: Bieback, Karen
  organization: Institute of Transfusion Medicine and Immunology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
– sequence: 5
  givenname: Olle
  surname: Ringdén
  fullname: Ringdén, Olle
  organization: Translational Cell Therapy Research (TCR), Department of Clinical Science, Intervention and Technology (CLINTEC), Karolinska Institutet, Stockholm, Sweden
– sequence: 6
  givenname: Hans-Dieter
  surname: Volk
  fullname: Volk, Hans-Dieter
  organization: Berlin-Brandenburg Center for Regenerative Therapies (BCRT), Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin (FUB), Humboldt-Universität zu Berlin (HUB), and Berlin Institute of Health (BIH), Berlin, Germany
– sequence: 7
  givenname: Sven
  surname: Geissler
  fullname: Geissler, Sven
  organization: Berlin-Brandenburg Center for Regenerative Therapies (BCRT), Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin (FUB), Humboldt-Universität zu Berlin (HUB), and Berlin Institute of Health (BIH), Berlin, Germany
– sequence: 8
  givenname: Petra
  surname: Reinke
  fullname: Reinke, Petra
  organization: Berlin-Brandenburg Center for Regenerative Therapies (BCRT), Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin (FUB), Humboldt-Universität zu Berlin (HUB), and Berlin Institute of Health (BIH), Berlin, Germany
BackLink https://www.ncbi.nlm.nih.gov/pubmed/30711482$$D View this record in MEDLINE/PubMed
http://kipublications.ki.se/Default.aspx?queryparsed=id:140276056$$DView record from Swedish Publication Index (Karolinska Institutet)
BookMark eNqFkUtv3CAUhVGVqnm0_6CqWHZjh-s3UVWpmjZppPQhZSp1hzBcK0ywmYA90fz7kng6i2xmxQXOOYLznZKjwQ1IyHtgKTCozldp72yPOs0YNClkKWPVK3ICRQ1Jwfnfo_0MxTE5DWHFGJR13bwhxzmrAYomOyH99TB6uZFBTVZ6-gMDDupu20tLb0fv4np-O2JPF2gtXd6hl-st_e2dntRIv5oN-mA6o-Ro3HBBl6ZH2jlPf-IjXVgzxBtLryajMW4wvCWvO2kDvtutZ-TP5bfl4nty8-vqevHlJlHx5WPSMgTsuJac6RorlmOhmiovoMt1wxkrISsZ1poXDMuq1UqXvEXOeZmVskOVn5Fkzg2PuJ5asfaml34rnDRid3QfJxSxgxyqqP8469fePUwYRtGboOKX5YBuCiKDmpfAy4ZF6YeddGpj-_vo_5VGQTELlHcheOz2EmDiiZxYiZmceCInIBORXLRdvLApMz7XGvkYe8j8eTZjLHVj0IugTASJ2nhUo9DOHAr49CJA7ejd4_aw_R-UuczK
CitedBy_id crossref_primary_10_1016_j_prp_2023_154541
crossref_primary_10_1177_0963689721995455
crossref_primary_10_3389_fimmu_2020_02029
crossref_primary_10_1093_stcltm_szac009
crossref_primary_10_1186_s13287_020_02121_8
crossref_primary_10_1038_s41551_021_00729_6
crossref_primary_10_3390_pharmaceutics13101543
crossref_primary_10_1002_cbf_3670
crossref_primary_10_1016_j_intimp_2021_107694
crossref_primary_10_1080_17458080_2021_1983172
crossref_primary_10_1186_s12967_020_02657_6
crossref_primary_10_3389_fcell_2021_661532
crossref_primary_10_3389_fimmu_2019_01151
crossref_primary_10_1002_cbf_70021
crossref_primary_10_1186_s13287_023_03552_9
crossref_primary_10_1016_j_biopha_2022_112920
crossref_primary_10_1186_s13287_021_02388_5
crossref_primary_10_1007_s11626_024_00849_8
crossref_primary_10_1016_j_cej_2024_155585
crossref_primary_10_3389_fimmu_2019_01952
crossref_primary_10_34172_apb_2024_052
crossref_primary_10_1016_j_jcyt_2019_05_003
crossref_primary_10_1007_s40778_022_00207_y
crossref_primary_10_3390_ijms21197194
crossref_primary_10_1186_s13287_020_01849_7
crossref_primary_10_1038_s41536_022_00244_5
crossref_primary_10_3389_fimmu_2023_1225047
crossref_primary_10_3389_fimmu_2023_1240347
crossref_primary_10_1186_s13287_023_03443_z
crossref_primary_10_3389_fimmu_2024_1379134
crossref_primary_10_1016_j_bonr_2022_101636
crossref_primary_10_1007_s40778_022_00210_3
crossref_primary_10_1186_s13287_020_01963_6
crossref_primary_10_1007_s11427_021_2022_5
crossref_primary_10_14348_molcells_2021_0101
crossref_primary_10_3389_fimmu_2022_1010700
crossref_primary_10_3390_ijms23042038
crossref_primary_10_1016_j_jcyt_2023_11_010
crossref_primary_10_1177_09636897221147920
crossref_primary_10_1002_ctm2_1163
crossref_primary_10_1016_j_tice_2024_102709
crossref_primary_10_3389_fcell_2019_00255
crossref_primary_10_3389_fimmu_2022_839844
crossref_primary_10_1073_pnas_2407809121
crossref_primary_10_1080_14712598_2025_2465826
crossref_primary_10_1080_20013078_2019_1609206
crossref_primary_10_1093_stmcls_sxad014
crossref_primary_10_1002_sctm_19_0073
crossref_primary_10_1016_j_intimp_2023_110890
crossref_primary_10_1093_burnst_tkac028
crossref_primary_10_1002_adbi_202400201
crossref_primary_10_1007_s40778_025_00244_3
crossref_primary_10_1186_s13287_022_02838_8
crossref_primary_10_1016_j_jcyt_2021_10_004
crossref_primary_10_1007_s13577_025_01213_y
crossref_primary_10_1038_s41598_019_54462_x
crossref_primary_10_1111_jcmm_15717
crossref_primary_10_3389_fncel_2022_932281
crossref_primary_10_1186_s13287_021_02304_x
crossref_primary_10_3390_ijms22073397
crossref_primary_10_3390_cells11142175
crossref_primary_10_1002_smll_202401472
crossref_primary_10_1080_17425247_2021_1960309
crossref_primary_10_4142_jvs_23300
crossref_primary_10_2217_rme_2023_0193
crossref_primary_10_1186_s12916_023_02923_6
crossref_primary_10_3389_fimmu_2020_607030
crossref_primary_10_1002_sctm_21_0043
crossref_primary_10_3389_fimmu_2023_1214098
crossref_primary_10_3389_fcell_2021_650664
crossref_primary_10_3389_fphar_2021_662437
crossref_primary_10_1097_TP_0000000000003429
crossref_primary_10_3389_fbioe_2024_1412811
crossref_primary_10_1186_s12967_020_02380_2
crossref_primary_10_1002_stem_3151
crossref_primary_10_1111_bjh_16389
crossref_primary_10_3389_fbioe_2022_969927
crossref_primary_10_1186_s12929_021_00725_7
crossref_primary_10_3389_fimmu_2019_02685
crossref_primary_10_1016_j_stem_2022_10_001
crossref_primary_10_1093_stcltm_szab005
crossref_primary_10_3389_fimmu_2020_01091
crossref_primary_10_4252_wjsc_v17_i8_111497
crossref_primary_10_1089_scd_2019_0225
crossref_primary_10_1186_s13287_023_03561_8
crossref_primary_10_3389_fcell_2021_654210
crossref_primary_10_3389_fcvm_2022_981088
crossref_primary_10_1002_advs_202303349
crossref_primary_10_1186_s12886_021_02171_3
crossref_primary_10_1016_j_cellimm_2023_104771
crossref_primary_10_1002_jev2_12022
crossref_primary_10_1016_j_omtm_2020_01_005
crossref_primary_10_1016_j_jcyt_2022_10_004
crossref_primary_10_1186_s13287_024_03885_z
crossref_primary_10_1038_s41392_022_01134_4
crossref_primary_10_1016_j_transci_2021_103237
crossref_primary_10_3390_cells8080846
crossref_primary_10_1016_j_jcyt_2024_10_009
crossref_primary_10_3389_fbioe_2022_863969
crossref_primary_10_3389_fimmu_2019_02474
crossref_primary_10_3389_fcell_2021_621645
crossref_primary_10_1016_j_jcyt_2020_12_004
crossref_primary_10_3389_fimmu_2022_821681
crossref_primary_10_3390_cells12010120
crossref_primary_10_1016_j_biomaterials_2021_120963
crossref_primary_10_3390_ijms22031404
crossref_primary_10_1007_s00018_021_04096_y
crossref_primary_10_3390_life12050654
crossref_primary_10_3390_ijms242316920
crossref_primary_10_1111_xen_12831
crossref_primary_10_3390_cells11060946
crossref_primary_10_1093_stcltm_szae065
crossref_primary_10_1002_wnan_1898
crossref_primary_10_1007_s10616_021_00461_8
crossref_primary_10_3389_fmed_2021_728496
crossref_primary_10_3389_fcell_2021_716853
crossref_primary_10_3390_ijms22136868
crossref_primary_10_3390_ijms24087299
crossref_primary_10_1038_s41536_019_0083_6
crossref_primary_10_1186_s12967_021_02840_3
crossref_primary_10_3390_biology12050725
crossref_primary_10_1016_j_bioactmat_2020_12_021
crossref_primary_10_1089_ten_tec_2021_0001
crossref_primary_10_3390_cells9071580
crossref_primary_10_3390_ijms242216040
crossref_primary_10_3390_cells8101160
crossref_primary_10_3389_fcell_2020_587866
crossref_primary_10_1016_j_stem_2025_05_008
crossref_primary_10_3389_fbioe_2022_981061
crossref_primary_10_1016_j_biomaterials_2022_121484
crossref_primary_10_12998_wjcc_v11_i21_5083
crossref_primary_10_3389_fimmu_2020_00243
crossref_primary_10_1080_10826068_2021_1983830
crossref_primary_10_1002_sctm_21_0083
crossref_primary_10_1089_ten_teb_2023_0196
crossref_primary_10_1155_2021_5513309
crossref_primary_10_1002_sctm_20_0239
crossref_primary_10_3389_fcell_2024_1456416
crossref_primary_10_1186_s13287_022_03176_5
crossref_primary_10_3390_antiox14010109
crossref_primary_10_3389_fimmu_2021_714723
crossref_primary_10_3389_fgene_2021_650536
crossref_primary_10_1111_sji_13267
crossref_primary_10_2147_JIR_S396064
crossref_primary_10_3389_fbioe_2022_977590
crossref_primary_10_1002_adhm_202001948
crossref_primary_10_3389_fimmu_2021_708950
crossref_primary_10_1002_ctm2_297
crossref_primary_10_1093_stmcls_sxae040
crossref_primary_10_3389_fimmu_2022_943333
crossref_primary_10_3389_fimmu_2024_1516554
crossref_primary_10_3389_fcell_2021_717913
crossref_primary_10_1111_jnc_15267
crossref_primary_10_52601_bpr_2024_240005
crossref_primary_10_1002_sctm_19_0019
crossref_primary_10_1186_s13287_023_03582_3
crossref_primary_10_3233_STJ_210002
crossref_primary_10_1016_j_stem_2021_09_006
crossref_primary_10_3389_fphar_2020_00404
crossref_primary_10_3389_fimmu_2023_1074863
crossref_primary_10_3390_cells11193158
crossref_primary_10_3390_ijms22063023
crossref_primary_10_1038_s41428_024_00934_5
crossref_primary_10_1681_ASN_0000000000000189
crossref_primary_10_3389_fphar_2021_692551
crossref_primary_10_3390_ijms24119216
crossref_primary_10_1002_stem_3357
crossref_primary_10_1093_brain_awae005
crossref_primary_10_1080_09537104_2020_1856356
crossref_primary_10_1186_s13287_021_02248_2
crossref_primary_10_1016_j_jcyt_2020_11_007
crossref_primary_10_3389_fimmu_2023_1200180
crossref_primary_10_1016_j_burns_2020_04_012
crossref_primary_10_1182_bloodadvances_2020001711
crossref_primary_10_3389_fimmu_2021_623973
crossref_primary_10_3389_fmed_2021_767291
crossref_primary_10_1007_s12035_022_02761_2
crossref_primary_10_1016_j_jconrel_2024_02_047
crossref_primary_10_1093_stmcls_sxae054
crossref_primary_10_3389_fmed_2021_655268
crossref_primary_10_1002_mco2_74
crossref_primary_10_1186_s13287_023_03380_x
crossref_primary_10_1111_jcmm_17471
crossref_primary_10_1016_j_heliyon_2024_e25460
crossref_primary_10_4252_wjsc_v13_i6_521
crossref_primary_10_1002_sctm_20_0454
crossref_primary_10_3390_cells10040910
crossref_primary_10_3389_fimmu_2023_1078551
crossref_primary_10_1016_j_colsurfb_2024_113942
crossref_primary_10_1155_2023_7397819
crossref_primary_10_1111_sji_13246
crossref_primary_10_3389_fimmu_2020_01306
crossref_primary_10_1016_j_jcyt_2021_04_004
crossref_primary_10_3389_fbioe_2020_619980
crossref_primary_10_1016_j_jcyt_2021_04_009
crossref_primary_10_1186_s11658_022_00325_9
crossref_primary_10_3390_ijms23158268
crossref_primary_10_1038_s41401_024_01327_3
crossref_primary_10_1088_1758_5090_ac0982
crossref_primary_10_3390_cells12060850
crossref_primary_10_3390_cells8101127
crossref_primary_10_1177_17534666231158276
crossref_primary_10_1186_s13287_023_03352_1
crossref_primary_10_3389_fmed_2021_739987
crossref_primary_10_1186_s12951_021_01113_x
crossref_primary_10_1016_j_actbio_2020_04_035
crossref_primary_10_3389_fimmu_2019_01080
crossref_primary_10_1093_stmcls_sxac059
crossref_primary_10_1186_s13287_024_03963_2
crossref_primary_10_1016_j_ymthe_2025_02_003
crossref_primary_10_1016_j_actbio_2019_08_033
crossref_primary_10_1002_btm2_10675
crossref_primary_10_1038_s41423_023_01022_z
crossref_primary_10_3389_fimmu_2021_698070
crossref_primary_10_3389_fcell_2022_956274
crossref_primary_10_1007_s12015_024_10705_7
crossref_primary_10_1007_s12026_023_09385_1
crossref_primary_10_3390_ijms222112041
crossref_primary_10_1016_j_ejpb_2022_01_007
crossref_primary_10_3389_fimmu_2019_01645
crossref_primary_10_1089_omi_2021_0049
crossref_primary_10_1186_s13287_025_04378_3
crossref_primary_10_1002_sctm_19_0206
crossref_primary_10_1186_s12951_023_01944_w
crossref_primary_10_3389_fbioe_2023_1213021
crossref_primary_10_1089_scd_2019_0176
crossref_primary_10_1186_s13287_020_01855_9
crossref_primary_10_3390_ijms22084178
crossref_primary_10_1016_j_omtm_2021_05_004
crossref_primary_10_1007_s12672_024_01590_0
crossref_primary_10_12688_f1000research_21862_1
crossref_primary_10_3390_ijms231810393
crossref_primary_10_1093_stmcls_sxac066
crossref_primary_10_1097_TP_0000000000004130
crossref_primary_10_1002_smll_202202309
crossref_primary_10_1093_stmcls_sxac062
crossref_primary_10_3390_ijms252413562
crossref_primary_10_3389_fimmu_2020_609063
crossref_primary_10_1093_stcltm_szad029
crossref_primary_10_1111_bjh_18292
crossref_primary_10_1016_j_jmii_2025_07_004
crossref_primary_10_2147_BTT_S404421
crossref_primary_10_3389_fimmu_2024_1393026
crossref_primary_10_1080_14712598_2022_2016695
crossref_primary_10_4252_wjsc_v17_i9_109715
crossref_primary_10_1016_j_biomaterials_2024_122757
crossref_primary_10_54537_tusebdergisi_983736
crossref_primary_10_1016_j_jcyt_2021_11_009
crossref_primary_10_1089_dna_2022_0327
crossref_primary_10_1186_s13287_025_04289_3
crossref_primary_10_1186_s13287_021_02430_6
crossref_primary_10_3389_fimmu_2021_774052
crossref_primary_10_1134_S1990519X25040030
crossref_primary_10_1002_btm2_70000
crossref_primary_10_3389_fbioe_2022_916229
crossref_primary_10_1038_s41419_021_03839_w
crossref_primary_10_1007_s40778_022_00212_1
crossref_primary_10_1016_j_jcyt_2023_04_013
crossref_primary_10_3390_jcm9010278
crossref_primary_10_1038_s41392_024_01936_8
crossref_primary_10_3389_fimmu_2020_00143
crossref_primary_10_1016_j_biopha_2023_115896
crossref_primary_10_1016_j_lfs_2023_121658
crossref_primary_10_1111_cas_15789
crossref_primary_10_1186_s12951_025_03297_y
crossref_primary_10_1007_s10565_024_09911_3
crossref_primary_10_1007_s40778_023_00232_5
crossref_primary_10_1093_stcltm_szad003
crossref_primary_10_3389_fcell_2022_902677
crossref_primary_10_3389_fimmu_2023_1192636
crossref_primary_10_1016_j_ejphar_2024_176719
crossref_primary_10_1007_s12015_022_10397_x
crossref_primary_10_3389_fimmu_2022_892443
crossref_primary_10_1080_1744666X_2023_2299729
crossref_primary_10_1007_s10815_023_02856_2
crossref_primary_10_3390_biomedicines10020253
crossref_primary_10_1155_2020_5924983
crossref_primary_10_3389_fbioe_2022_910812
crossref_primary_10_3389_fcell_2020_00316
crossref_primary_10_1007_s40778_024_00242_x
crossref_primary_10_1088_1758_5090_ac0a32
crossref_primary_10_1038_s41598_024_63118_4
crossref_primary_10_1186_s13287_021_02502_7
crossref_primary_10_1186_s13287_021_02158_3
crossref_primary_10_1016_j_bioadv_2023_213331
crossref_primary_10_1186_s13287_025_04512_1
crossref_primary_10_1080_15384101_2025_2485834
crossref_primary_10_3390_biomedicines13081801
crossref_primary_10_1186_s13287_023_03446_w
Cites_doi 10.1634/stemcells.2007-0023
10.1007/s12015-010-9212-8
10.1111/voxs.12133
10.1016/j.stem.2009.02.001
10.1002/sctm.18-0015
10.1182/blood-2002-06-1830
10.3349/ymj.2013.54.5.1293
10.1016/j.jcyt.2015.11.008
10.1182/blood-2012-03-420612
10.7150/thno.16911
10.1016/j.stem.2014.01.013
10.1146/annurev.med.47.1.315
10.1016/j.mvr.2009.02.001
10.1038/nature09262
10.1056/NEJMp1613723
10.1186/s13287-018-0936-8
10.7150/thno.21906
10.1371/journal.pone.0021703
10.1038/nm.3028
10.1016/j.bbrc.2012.12.134
10.1002/stem.1729
10.1038/ni.1923
10.1002/stem.1198
10.3389/fimmu.2018.02237
10.1016/j.stem.2008.10.017
10.1089/scd.2015.0120
10.1007/978-3-319-18603-0_1
10.1161/CIRCRESAHA.108.187724
10.1016/S0140-6736(02)12020-4
10.3727/096368916X692609
10.2337/diabetes.50.4.710
10.1016/j.placenta.2014.12.014
10.1161/ATVBAHA.107.160317
10.1002/stem.2891
10.1038/nature06685
10.4049/jimmunol.0803055
10.1002/jor.21167
10.1016/j.biomaterials.2016.05.055
10.1093/rheumatology/kem206
10.1002/stem.2050
10.1089/scd.2014.0269
10.1371/journal.pone.0085040
10.1371/journal.pone.0060461
10.1182/blood.V76.1.86.86
10.1016/j.biomaterials.2015.02.110
10.1126/science.284.5411.143
10.1186/scrt198
10.1016/j.molmed.2010.02.005
10.1016/j.stem.2008.03.002
10.1038/468485a
10.1016/j.ymthe.2018.08.011
10.1634/stemcells.2007-0140
10.1080/14653240600855905
10.1038/6529
10.1089/scd.2008.0253
10.1016/j.it.2007.02.006
10.1056/NEJM200007273430401
10.1634/stemcells.2006-0335
10.1016/j.msard.2014.08.002
10.1002/stem.1118
10.1002/sctm.17-0031
10.3109/14653240903401840
10.1186/s13287-018-1053-4
10.1002/stem.1452
10.1097/MIB.0000000000000441
10.1038/s41586-018-0698-6
10.1038/nrgastro.2013.204
10.1126/science.275.5302.964
10.1016/j.stem.2018.05.004
10.1016/S2352-3026(15)00224-0
10.1016/j.ekir.2018.05.009
10.1159/000485735
10.1016/j.tcm.2015.12.001
10.1038/nbt.2816
10.3389/fimmu.2017.00795
10.1007/978-3-319-45457-3_7
10.1002/sctm.17-0167
10.1371/journal.pone.0047559
10.1111/hepr.12507
10.1097/00007890-197404000-00001
10.5966/sctm.2015-0272
10.2337/diabetes.48.10.1907
10.1016/j.it.2009.09.005
10.1172/JCI23284
10.1016/j.stem.2008.07.003
10.1097/TA.0000000000001485
10.1634/stemcells.2007-0594
10.2337/db13-0896
10.1016/j.transproceed.2017.03.078
10.1016/S0140-6736(04)15695-X
10.1073/pnas.132252399
10.1371/journal.pone.0042819
10.1161/CIRCULATIONAHA.105.567297
10.1089/scd.2015.0329
10.1038/mt.2016.142
10.1097/TP.0b013e3181c478fd
10.1016/S2213-2600(15)00047-8
10.1002/stem.1111
ContentType Journal Article
Copyright 2019 The Authors
Copyright © 2018 Elsevier Ltd. All rights reserved.
Copyright_xml – notice: 2019 The Authors
– notice: Copyright © 2018 Elsevier Ltd. All rights reserved.
DBID 6I.
AAFTH
AAYXX
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
7X8
ADTPV
AOWAS
D8T
ZZAVC
DOI 10.1016/j.molmed.2018.12.006
DatabaseName ScienceDirect Open Access Titles
Elsevier:ScienceDirect:Open Access
CrossRef
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
MEDLINE - Academic
SwePub
SwePub Articles
SWEPUB Freely available online
SwePub Articles full text
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
MEDLINE - Academic
DatabaseTitleList

MEDLINE
MEDLINE - Academic
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: 7X8
  name: MEDLINE - Academic
  url: https://search.proquest.com/medline
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
Biology
EISSN 1471-499X
EndPage 163
ExternalDocumentID oai_swepub_ki_se_482316
30711482
10_1016_j_molmed_2018_12_006
S1471491418302405
Genre Research Support, Non-U.S. Gov't
Journal Article
Review
GroupedDBID ---
--K
--M
.1-
.FO
.~1
0R~
123
1B1
1P~
1RT
1~.
1~5
29Q
4.4
457
4G.
53G
5VS
7-5
71M
8P~
AAEDT
AAEDW
AAIKJ
AAKOC
AALRI
AAMRU
AAOAW
AAQFI
AAQXK
AATTM
AAXKI
AAXUO
AAYWO
ABBQC
ABFNM
ABGSF
ABJNI
ABMAC
ABMZM
ABUDA
ABWVN
ABXDB
ACDAQ
ACGFS
ACIEU
ACIWK
ACLOT
ACPRK
ACRLP
ACRPL
ACVFH
ADBBV
ADCNI
ADEZE
ADMUD
ADNMO
ADUVX
AEBSH
AEHWI
AEIPS
AEKER
AENEX
AEUPX
AEVXI
AFPUW
AFRAH
AFRHN
AFTJW
AFXIZ
AGHFR
AGQPQ
AGRDE
AGUBO
AGYEJ
AIEXJ
AIGII
AIIUN
AIKHN
AITUG
AJRQY
AJUYK
AKBMS
AKRWK
AKYEP
ALMA_UNASSIGNED_HOLDINGS
AMRAJ
ANKPU
ANZVX
APXCP
ASPBG
AVWKF
AXJTR
AZFZN
BKOJK
BLXMC
BNPGV
CS3
DU5
EBS
EFJIC
EFKBS
EFLBG
EJD
EO8
EO9
EP2
EP3
F5P
FDB
FEDTE
FGOYB
FIRID
FNPLU
FYGXN
G-Q
GBLVA
HVGLF
HZ~
IHE
J1W
K-O
KOM
L7B
M41
MO0
N9A
O-L
O9-
O9.
OAUVE
OK~
OZT
P-8
P-9
PC.
Q38
R2-
ROL
RPZ
SCC
SDF
SDG
SDP
SES
SEW
SPCBC
SSH
SSU
SSZ
T5K
Z5R
~G-
~HD
6I.
AACTN
AAFTH
AAIAV
ABLVK
ABYKQ
AFCTW
AFKWA
AJBFU
AJOXV
AMFUW
DOVZS
LCYCR
RCE
RIG
9DU
AAYXX
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
7X8
ADTPV
AOWAS
D8T
ZZAVC
ID FETCH-LOGICAL-c499t-b0e1ef9da90d7e603e4c86341f3d890051250e7d940e56bdcd59be999525afec3
ISICitedReferencesCount 312
ISICitedReferencesURI http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000458294300010&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN 1471-4914
1471-499X
IngestDate Tue Nov 25 03:38:18 EST 2025
Wed Oct 01 14:26:44 EDT 2025
Wed Feb 19 02:32:04 EST 2025
Sat Nov 29 07:03:47 EST 2025
Tue Nov 18 22:18:32 EST 2025
Fri Feb 23 02:49:45 EST 2024
Tue Oct 14 19:36:11 EDT 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 2
Keywords CD142
hemocompatibility
tissue factor
safety and efficacy
cellular therapy
mesenchymal stromal/stem cell
tissue source
Language English
License This is an open access article under the CC BY license.
Copyright © 2018 Elsevier Ltd. All rights reserved.
LinkModel OpenURL
MergedId FETCHMERGED-LOGICAL-c499t-b0e1ef9da90d7e603e4c86341f3d890051250e7d940e56bdcd59be999525afec3
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
content type line 23
ORCID 0000-0001-6173-5957
OpenAccessLink http://kipublications.ki.se/Default.aspx?queryparsed=id:140276056
PMID 30711482
PQID 2179519580
PQPubID 23479
PageCount 15
ParticipantIDs swepub_primary_oai_swepub_ki_se_482316
proquest_miscellaneous_2179519580
pubmed_primary_30711482
crossref_primary_10_1016_j_molmed_2018_12_006
crossref_citationtrail_10_1016_j_molmed_2018_12_006
elsevier_sciencedirect_doi_10_1016_j_molmed_2018_12_006
elsevier_clinicalkey_doi_10_1016_j_molmed_2018_12_006
PublicationCentury 2000
PublicationDate 2019-02-01
PublicationDateYYYYMMDD 2019-02-01
PublicationDate_xml – month: 02
  year: 2019
  text: 2019-02-01
  day: 01
PublicationDecade 2010
PublicationPlace England
PublicationPlace_xml – name: England
PublicationTitle Trends in molecular medicine
PublicationTitleAlternate Trends Mol Med
PublicationYear 2019
Publisher Elsevier Ltd
Publisher_xml – name: Elsevier Ltd
References Ankrum (bib0020) 2014; 32
Moll (bib0035) 2012; 30
Ekdahl (bib0370) 2018; 9
Ringden (bib0380) 2015; 3
Qazi (bib0480) 2015; 53
Perlee (bib0125) 2018; 36
Baygan (bib0395) 2017; 8
Li (bib0490) 2016; 102
Liao (bib0120) 2017; 7
Toyserkani (bib0415) 2017; 6
Mendicino (bib0010) 2014; 14
Thomas (bib0320) 2008; 28
Gustafson (bib0445) 2017; 26
He (bib0255) 2007; 25
Parolini (bib0180) 2008; 26
Li (bib0495) 2016; 24
Li, Lin (bib0350) 2012; 120
Wu (bib0060) 2017; 49
Markiewski (bib0360) 2007; 28
Oeller (bib0115) 2018; 8
Dominici (bib0130) 2006; 8
Shapiro (bib0225) 2000; 343
Lublin (bib0385) 2014; 3
Galipeau, Sensebe (bib0005) 2018; 22
von Bahr (bib0150) 2012; 30
Crisan (bib0165) 2008; 3
Stephenne (bib0085) 2012; 7
Miller (bib0475) 2018; 3
Acosta (bib0410) 2013; 62
Bennet (bib0270) 1999; 48
Tatsumi (bib0090) 2013; 431
Horwitz (bib0160) 2002; 99
Hoogduijn (bib0405) 2016; 25
Alm (bib0330) 2010; 28
Davies (bib0425) 2016; 5
Cyranoski (bib0050) 2010; 468
Faulk (bib0215) 1990; 76
Schraufstatter (bib0305) 2009; 182
Hashmi (bib0375) 2016; 3
Ryan (bib0230) 2001; 50
Ekdahl (bib0265) 2015; 865
Fischer (bib0280) 2009; 18
Toma (bib0080) 2009; 104
Pitchford (bib0295) 2009; 4
Moberg (bib0220) 2002; 360
Karp, Leng Teo (bib0245) 2009; 4
Moll (bib0310) 2011; 6
Asahara (bib0285) 1997; 275
Mendez-Ferrer (bib0315) 2008; 452
Aronsson-Kurttila (bib0465) 2018; 139
Mendez-Ferrer (bib0290) 2010; 466
Ankrum, Karp (bib0015) 2010; 16
Tsai (bib0175) 2007; 25
Struecker (bib0470) 2014; 11
Teo (bib0335) 2012; 30
Jung (bib0055) 2013; 54
Melmed (bib0390) 2015; 21
Wu, Thiagarajan (bib0340) 1996; 47
Nilsson (bib0240) 2010; 31
Lalu (bib0040) 2012; 7
Vulliet (bib0070) 2004; 363
Moll (bib0200) 2014; 32
Witkowski (bib0205) 2016; 26
Friedenstein (bib0140) 1974; 17
Hoogduijn (bib0325) 2014; 23
Bianco (bib0170) 2008; 2
Jones, McGonagle (bib0260) 2008; 47
Netsch (bib0450) 2018; 9
Griffin (bib0030) 2013; 31
Drake (bib0210) 1989; 134
Furlani (bib0075) 2009; 77
Koh (bib0235) 2010; 89
Ringden (bib0195) 2018; 7
Marks (bib0045) 2017; 376
Moll, Le Blanc (bib0455) 2015; 10
Moll (bib0460) 2016; 951
Soland (bib0485) 2013; 8
Marquez-Curtis (bib0300) 2011; 7
Christy (bib0110) 2017; 83
Pittenger (bib0145) 1999; 284
Bianco (bib0025) 2013; 19
Horwitz (bib0155) 1999; 5
Vento-Tormo (bib0190) 2018; 563
Gleeson (bib0095) 2015; 33
Capilla-Gonzalez (bib0420) 2018; 26
Nachman, Jaffe (bib0345) 2004; 114
Galipeau (bib0135) 2016; 18
Ricklin (bib0365) 2010; 11
Liang (bib0400) 2018; 9
Devine (bib0275) 2003; 101
Moll (bib0100) 2015; 24
Shiratsuki (bib0105) 2015; 45
Quimby (bib0440) 2013; 4
George (bib0065) 2018; 7
Kusuma (bib0185) 2015; 36
Moll (bib0430) 2014; 9
Deak (bib0435) 2010; 12
Steffel (bib0355) 2006; 113
Kuznetsov (bib0250) 2007; 25
Griffin (10.1016/j.molmed.2018.12.006_bib0030) 2013; 31
Dominici (10.1016/j.molmed.2018.12.006_bib0130) 2006; 8
Moll (10.1016/j.molmed.2018.12.006_bib0035) 2012; 30
Oeller (10.1016/j.molmed.2018.12.006_bib0115) 2018; 8
He (10.1016/j.molmed.2018.12.006_bib0255) 2007; 25
Moll (10.1016/j.molmed.2018.12.006_bib0430) 2014; 9
von Bahr (10.1016/j.molmed.2018.12.006_bib0150) 2012; 30
Gustafson (10.1016/j.molmed.2018.12.006_bib0445) 2017; 26
Wu (10.1016/j.molmed.2018.12.006_bib0060) 2017; 49
Thomas (10.1016/j.molmed.2018.12.006_bib0320) 2008; 28
Marks (10.1016/j.molmed.2018.12.006_bib0045) 2017; 376
Gleeson (10.1016/j.molmed.2018.12.006_bib0095) 2015; 33
Tsai (10.1016/j.molmed.2018.12.006_bib0175) 2007; 25
Kusuma (10.1016/j.molmed.2018.12.006_bib0185) 2015; 36
Pitchford (10.1016/j.molmed.2018.12.006_bib0295) 2009; 4
Ringden (10.1016/j.molmed.2018.12.006_bib0380) 2015; 3
Fischer (10.1016/j.molmed.2018.12.006_bib0280) 2009; 18
Ekdahl (10.1016/j.molmed.2018.12.006_bib0370) 2018; 9
Markiewski (10.1016/j.molmed.2018.12.006_bib0360) 2007; 28
Qazi (10.1016/j.molmed.2018.12.006_bib0480) 2015; 53
Toma (10.1016/j.molmed.2018.12.006_bib0080) 2009; 104
Moll (10.1016/j.molmed.2018.12.006_bib0100) 2015; 24
Li (10.1016/j.molmed.2018.12.006_bib0495) 2016; 24
Alm (10.1016/j.molmed.2018.12.006_bib0330) 2010; 28
Hoogduijn (10.1016/j.molmed.2018.12.006_bib0405) 2016; 25
Liang (10.1016/j.molmed.2018.12.006_bib0400) 2018; 9
Melmed (10.1016/j.molmed.2018.12.006_bib0390) 2015; 21
Marquez-Curtis (10.1016/j.molmed.2018.12.006_bib0300) 2011; 7
Pittenger (10.1016/j.molmed.2018.12.006_bib0145) 1999; 284
Koh (10.1016/j.molmed.2018.12.006_bib0235) 2010; 89
Schraufstatter (10.1016/j.molmed.2018.12.006_bib0305) 2009; 182
Ryan (10.1016/j.molmed.2018.12.006_bib0230) 2001; 50
Perlee (10.1016/j.molmed.2018.12.006_bib0125) 2018; 36
Asahara (10.1016/j.molmed.2018.12.006_bib0285) 1997; 275
George (10.1016/j.molmed.2018.12.006_bib0065) 2018; 7
Parolini (10.1016/j.molmed.2018.12.006_bib0180) 2008; 26
Ankrum (10.1016/j.molmed.2018.12.006_bib0015) 2010; 16
Ringden (10.1016/j.molmed.2018.12.006_bib0195) 2018; 7
Hashmi (10.1016/j.molmed.2018.12.006_bib0375) 2016; 3
Davies (10.1016/j.molmed.2018.12.006_bib0425) 2016; 5
Li (10.1016/j.molmed.2018.12.006_bib0350) 2012; 120
Nachman (10.1016/j.molmed.2018.12.006_bib0345) 2004; 114
Kuznetsov (10.1016/j.molmed.2018.12.006_bib0250) 2007; 25
Furlani (10.1016/j.molmed.2018.12.006_bib0075) 2009; 77
Faulk (10.1016/j.molmed.2018.12.006_bib0215) 1990; 76
Teo (10.1016/j.molmed.2018.12.006_bib0335) 2012; 30
Acosta (10.1016/j.molmed.2018.12.006_bib0410) 2013; 62
Crisan (10.1016/j.molmed.2018.12.006_bib0165) 2008; 3
Miller (10.1016/j.molmed.2018.12.006_bib0475) 2018; 3
Cyranoski (10.1016/j.molmed.2018.12.006_bib0050) 2010; 468
Tatsumi (10.1016/j.molmed.2018.12.006_bib0090) 2013; 431
Bennet (10.1016/j.molmed.2018.12.006_bib0270) 1999; 48
Ricklin (10.1016/j.molmed.2018.12.006_bib0365) 2010; 11
Bianco (10.1016/j.molmed.2018.12.006_bib0170) 2008; 2
Deak (10.1016/j.molmed.2018.12.006_bib0435) 2010; 12
Vulliet (10.1016/j.molmed.2018.12.006_bib0070) 2004; 363
Moll (10.1016/j.molmed.2018.12.006_bib0310) 2011; 6
Quimby (10.1016/j.molmed.2018.12.006_bib0440) 2013; 4
Lalu (10.1016/j.molmed.2018.12.006_bib0040) 2012; 7
Devine (10.1016/j.molmed.2018.12.006_bib0275) 2003; 101
Horwitz (10.1016/j.molmed.2018.12.006_bib0160) 2002; 99
Baygan (10.1016/j.molmed.2018.12.006_bib0395) 2017; 8
Horwitz (10.1016/j.molmed.2018.12.006_bib0155) 1999; 5
Ekdahl (10.1016/j.molmed.2018.12.006_bib0265) 2015; 865
Steffel (10.1016/j.molmed.2018.12.006_bib0355) 2006; 113
Shapiro (10.1016/j.molmed.2018.12.006_bib0225) 2000; 343
Moll (10.1016/j.molmed.2018.12.006_bib0455) 2015; 10
Ankrum (10.1016/j.molmed.2018.12.006_bib0020) 2014; 32
Liao (10.1016/j.molmed.2018.12.006_bib0120) 2017; 7
Karp (10.1016/j.molmed.2018.12.006_bib0245) 2009; 4
Mendez-Ferrer (10.1016/j.molmed.2018.12.006_bib0315) 2008; 452
Witkowski (10.1016/j.molmed.2018.12.006_bib0205) 2016; 26
Hoogduijn (10.1016/j.molmed.2018.12.006_bib0325) 2014; 23
Capilla-Gonzalez (10.1016/j.molmed.2018.12.006_bib0420) 2018; 26
Wu (10.1016/j.molmed.2018.12.006_bib0340) 1996; 47
Mendez-Ferrer (10.1016/j.molmed.2018.12.006_bib0290) 2010; 466
Toyserkani (10.1016/j.molmed.2018.12.006_bib0415) 2017; 6
Shiratsuki (10.1016/j.molmed.2018.12.006_bib0105) 2015; 45
Moll (10.1016/j.molmed.2018.12.006_bib0200) 2014; 32
Aronsson-Kurttila (10.1016/j.molmed.2018.12.006_bib0465) 2018; 139
Moll (10.1016/j.molmed.2018.12.006_bib0460) 2016; 951
Drake (10.1016/j.molmed.2018.12.006_bib0210) 1989; 134
Netsch (10.1016/j.molmed.2018.12.006_bib0450) 2018; 9
Nilsson (10.1016/j.molmed.2018.12.006_bib0240) 2010; 31
Jones (10.1016/j.molmed.2018.12.006_bib0260) 2008; 47
Vento-Tormo (10.1016/j.molmed.2018.12.006_bib0190) 2018; 563
Galipeau (10.1016/j.molmed.2018.12.006_bib0135) 2016; 18
Christy (10.1016/j.molmed.2018.12.006_bib0110) 2017; 83
Struecker (10.1016/j.molmed.2018.12.006_bib0470) 2014; 11
Galipeau (10.1016/j.molmed.2018.12.006_bib0005) 2018; 22
Jung (10.1016/j.molmed.2018.12.006_bib0055) 2013; 54
Soland (10.1016/j.molmed.2018.12.006_bib0485) 2013; 8
Mendicino (10.1016/j.molmed.2018.12.006_bib0010) 2014; 14
Li (10.1016/j.molmed.2018.12.006_bib0490) 2016; 102
Moberg (10.1016/j.molmed.2018.12.006_bib0220) 2002; 360
Friedenstein (10.1016/j.molmed.2018.12.006_bib0140) 1974; 17
Bianco (10.1016/j.molmed.2018.12.006_bib0025) 2013; 19
Stephenne (10.1016/j.molmed.2018.12.006_bib0085) 2012; 7
Lublin (10.1016/j.molmed.2018.12.006_bib0385) 2014; 3
References_xml – volume: 3
  start-page: e12
  year: 2015
  ident: bib0380
  article-title: Mesenchymal stem (stromal) cells for treatment of acute respiratory distress syndrome
  publication-title: Lancet Respir. Med.
– volume: 32
  start-page: 252
  year: 2014
  end-page: 260
  ident: bib0020
  article-title: Mesenchymal stem cells: immune evasive, not immune privileged
  publication-title: Nat. Biotechnol.
– volume: 17
  start-page: 331
  year: 1974
  end-page: 340
  ident: bib0140
  article-title: Stromal cells responsible for transferring the microenvironment of the hemopoietic tissues. Cloning
  publication-title: Transplantation
– volume: 113
  start-page: 722
  year: 2006
  end-page: 731
  ident: bib0355
  article-title: Tissue factor in cardiovascular diseases: molecular mechanisms and clinical implications
  publication-title: Circulation
– volume: 3
  start-page: 696
  year: 2014
  end-page: 704
  ident: bib0385
  article-title: Human placenta-derived cells (PDA-001) for the treatment of adults with multiple sclerosis: a randomized, placebo-controlled, multiple-dose study
  publication-title: Multi Scler. Relat. Disord.
– volume: 28
  start-page: 184
  year: 2007
  end-page: 192
  ident: bib0360
  article-title: Complement and coagulation: strangers or partners in crime?
  publication-title: Trends Immunol.
– volume: 25
  start-page: 69
  year: 2007
  end-page: 77
  ident: bib0255
  article-title: Concise review: multipotent mesenchymal stromal cells in blood
  publication-title: Stem Cells
– volume: 33
  start-page: 2726
  year: 2015
  end-page: 2737
  ident: bib0095
  article-title: Bone marrow-derived mesenchymal stem cells have innate procoagulant activity and cause microvascular obstruction following intracoronary delivery: amelioration by antithrombin therapy
  publication-title: Stem Cells
– volume: 83
  start-page: S164
  year: 2017
  end-page: S169
  ident: bib0110
  article-title: Procoagulant activity of human mesenchymal stem cells
  publication-title: J. Trauma Acute Care Surg.
– volume: 10
  start-page: 357
  year: 2015
  end-page: 365
  ident: bib0455
  article-title: Engineering more efficient multipotent mesenchymal stromal (stem) cells for systemic delivery as cellular therapy
  publication-title: ISBT Sci. Ser.
– volume: 4
  start-page: 48
  year: 2013
  ident: bib0440
  article-title: Safety and efficacy of intravenous infusion of allogeneic cryopreserved mesenchymal stem cells for treatment of chronic kidney disease in cats: results of three sequential pilot studies
  publication-title: Stem Cell Res. Ther.
– volume: 8
  start-page: 795
  year: 2017
  ident: bib0395
  article-title: Safety and side effects of using placenta-derived decidual stromal cells for graft-versus-host disease and hemorrhagic cystitis
  publication-title: Front. Immunol.
– volume: 77
  start-page: 370
  year: 2009
  end-page: 376
  ident: bib0075
  article-title: Is the intravascular administration of mesenchymal stem cells safe? Mesenchymal stem cells and intravital microscopy
  publication-title: Microvasc. Res.
– volume: 22
  start-page: 824
  year: 2018
  end-page: 833
  ident: bib0005
  article-title: Mesenchymal stromal cells: clinical challenges and therapeutic opportunities
  publication-title: Cell Stem Cell
– volume: 31
  start-page: 2033
  year: 2013
  end-page: 2041
  ident: bib0030
  article-title: Concise review: adult mesenchymal stromal cell therapy for inflammatory diseases: how well are we joining the dots?
  publication-title: Stem Cells
– volume: 7
  start-page: 590
  year: 2011
  end-page: 607
  ident: bib0300
  article-title: The ins and outs of hematopoietic stem cells: studies to improve transplantation outcomes
  publication-title: Stem Cell Rev.
– volume: 139
  start-page: 106
  year: 2018
  end-page: 114
  ident: bib0465
  article-title: Placenta-derived decidua stromal cells for hemorrhagic cystitis after stem cell transplantation
  publication-title: Acta Haematol.
– volume: 363
  start-page: 783
  year: 2004
  end-page: 784
  ident: bib0070
  article-title: Intra-coronary arterial injection of mesenchymal stromal cells and microinfarction in dogs
  publication-title: Lancet
– volume: 23
  start-page: 2328
  year: 2014
  end-page: 2335
  ident: bib0325
  article-title: No evidence for circulating mesenchymal stem cells in patients with organ injury
  publication-title: Stem Cells Dev.
– volume: 30
  start-page: 1565
  year: 2012
  end-page: 1574
  ident: bib0035
  article-title: Are therapeutic human mesenchymal stromal cells compatible with human blood?
  publication-title: Stem Cells
– volume: 8
  year: 2013
  ident: bib0485
  article-title: Mesenchymal stem cells engineered to inhibit complement-mediated damage
  publication-title: PLoS One
– volume: 7
  year: 2012
  ident: bib0040
  article-title: Safety of cell therapy with mesenchymal stromal cells (SafeCell): a systematic review and meta-analysis of clinical trials
  publication-title: PLoS One
– volume: 8
  start-page: 315
  year: 2006
  end-page: 317
  ident: bib0130
  article-title: Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement
  publication-title: Cytotherapy
– volume: 6
  year: 2011
  ident: bib0310
  article-title: Mesenchymal stromal cells engage complement and complement receptor bearing innate effector cells to modulate immune responses
  publication-title: PLoS One
– volume: 102
  start-page: 209
  year: 2016
  end-page: 219
  ident: bib0490
  article-title: Painting factor H onto mesenchymal stem cells protects the cells from complement- and neutrophil-mediated damage
  publication-title: Biomaterials
– volume: 26
  start-page: 297
  year: 2016
  end-page: 303
  ident: bib0205
  article-title: Tissue factor as a link between inflammation and coagulation
  publication-title: Trends Cardiovasc. Med.
– volume: 26
  start-page: 2696
  year: 2018
  end-page: 2709
  ident: bib0420
  article-title: PDGF restores the defective phenotype of adipose-derived mesenchymal stromal cells from diabetic patients
  publication-title: Mol. Ther.
– volume: 24
  start-page: 1665
  year: 2016
  end-page: 1674
  ident: bib0495
  article-title: Local inhibition of complement improves mesenchymal stem cell viability and function after administration
  publication-title: Mol. Ther.
– volume: 284
  start-page: 143
  year: 1999
  end-page: 147
  ident: bib0145
  article-title: Multilineage potential of adult human mesenchymal stem cells
  publication-title: Science
– volume: 11
  start-page: 785
  year: 2010
  end-page: 797
  ident: bib0365
  article-title: Complement: a key system for immune surveillance and homeostasis
  publication-title: Nat. Immunol.
– volume: 182
  start-page: 3827
  year: 2009
  end-page: 3836
  ident: bib0305
  article-title: C3a and C5a are chemotactic factors for human mesenchymal stem cells, which cause prolonged ERK1/2 phosphorylation
  publication-title: J. Immunol.
– volume: 31
  start-page: 32
  year: 2010
  end-page: 38
  ident: bib0240
  article-title: Can cells and biomaterials in therapeutic medicine be shielded from innate immune recognition?
  publication-title: Trends Immunol.
– volume: 12
  start-page: 260
  year: 2010
  end-page: 264
  ident: bib0435
  article-title: Suspension medium influences interaction of mesenchymal stromal cells with endothelium and pulmonary toxicity after transplantation in mice
  publication-title: Cytotherapy
– volume: 9
  start-page: 2237
  year: 2018
  ident: bib0370
  article-title: Interpretation of serological complement biomarkers in disease
  publication-title: Front. Immunol.
– volume: 18
  start-page: 683
  year: 2009
  end-page: 692
  ident: bib0280
  article-title: Pulmonary passage is a major obstacle for intravenous stem cell delivery: the pulmonary first-pass effect
  publication-title: Stem Cells Dev.
– volume: 24
  start-page: 2269
  year: 2015
  end-page: 2279
  ident: bib0100
  article-title: Different procoagulant activity of therapeutic mesenchymal stromal cells derived from bone marrow and placental decidua
  publication-title: Stem Cells Dev.
– volume: 951
  start-page: 77
  year: 2016
  end-page: 98
  ident: bib0460
  article-title: Cryopreserved or fresh mesenchymal stromal cells: only a matter of taste or key to unleash the full clinical potential of MSC therapy?
  publication-title: Adv. Exp. Med. Biol.
– volume: 54
  start-page: 1293
  year: 2013
  end-page: 1296
  ident: bib0055
  article-title: Familial occurrence of pulmonary embolism after intravenous, adipose tissue-derived stem cell therapy
  publication-title: Yonsei Med. J.
– volume: 28
  start-page: e21
  year: 2008
  end-page: e22
  ident: bib0320
  article-title: Circulating endothelial progenitor cells exhibit diurnal variation
  publication-title: Arterioscler. Thromb. Vasc. Biol.
– volume: 28
  start-page: 1634
  year: 2010
  end-page: 1642
  ident: bib0330
  article-title: Circulating plastic adherent mesenchymal stem cells in aged hip fracture patients
  publication-title: J. Orthop. Res.
– volume: 120
  start-page: 3436
  year: 2012
  end-page: 3443
  ident: bib0350
  article-title: Mesenchymal stem cells are injured by complement after their contact with serum
  publication-title: Blood
– volume: 9
  start-page: 312
  year: 2018
  ident: bib0400
  article-title: Safety analysis in patients with autoimmune disease receiving allogeneic mesenchymal stem cells infusion: a long-term retrospective study
  publication-title: Stem Cell Res. Ther.
– volume: 468
  start-page: 485
  year: 2010
  ident: bib0050
  article-title: Korean deaths spark inquiry
  publication-title: Nature
– volume: 5
  start-page: 1485
  year: 2016
  end-page: 1495
  ident: bib0425
  article-title: Type 1 diabetes mellitus donor mesenchymal stromal cells exhibit comparable potency to healthy controls
  publication-title: Stem Cells Transl. Med.
– volume: 26
  start-page: 71
  year: 2017
  end-page: 81
  ident: bib0445
  article-title: Control of IBMIR induced by fresh and cryopreserved hepatocytes by low molecular weight dextran sulfate versus heparin
  publication-title: Cell Transplant.
– volume: 6
  start-page: 1786
  year: 2017
  end-page: 1794
  ident: bib0415
  article-title: Concise review: a safety assessment of adipose-derived cell therapy in clinical trials: a systematic review of reported adverse events
  publication-title: Stem Cells Transl. Med.
– volume: 18
  start-page: 151
  year: 2016
  end-page: 159
  ident: bib0135
  article-title: International Society for Cellular Therapy perspective on immune functional assays for mesenchymal stromal cells as potency release criterion for advanced phase clinical trials
  publication-title: Cytotherapy
– volume: 114
  start-page: 1037
  year: 2004
  end-page: 1040
  ident: bib0345
  article-title: Endothelial cell culture: beginnings of modern vascular biology
  publication-title: J. Clin. Invest.
– volume: 5
  start-page: 309
  year: 1999
  end-page: 313
  ident: bib0155
  article-title: Transplantability and therapeutic effects of bone marrow-derived mesenchymal cells in children with osteogenesis imperfecta
  publication-title: Nat. Med.
– volume: 360
  start-page: 2039
  year: 2002
  end-page: 2045
  ident: bib0220
  article-title: Production of tissue factor by pancreatic islet cells as a trigger of detrimental thrombotic reactions in clinical islet transplantation
  publication-title: Lancet
– volume: 50
  start-page: 710
  year: 2001
  end-page: 719
  ident: bib0230
  article-title: Clinical outcomes and insulin secretion after islet transplantation with the Edmonton protocol
  publication-title: Diabetes
– volume: 134
  start-page: 1087
  year: 1989
  end-page: 1097
  ident: bib0210
  article-title: Selective cellular expression of tissue factor in human tissues. Implications for disorders of hemostasis and thrombosis
  publication-title: Am. J. Pathol.
– volume: 36
  start-page: 312
  year: 2015
  end-page: 321
  ident: bib0185
  article-title: Mesenchymal stem cells reside in a vascular niche in the decidua basalis and are absent in remodelled spiral arterioles
  publication-title: Placenta
– volume: 3
  start-page: e45
  year: 2016
  end-page: 52
  ident: bib0375
  article-title: Survival after mesenchymal stromal cell therapy in steroid-refractory acute graft-versus-host disease: systematic review and meta-analysis
  publication-title: Lancet Haematol.
– volume: 45
  start-page: 1353
  year: 2015
  end-page: 1359
  ident: bib0105
  article-title: Enhanced survival of mice infused with bone marrow-derived as compared with adipose-derived mesenchymal stem cells
  publication-title: Hepatol. Res.
– volume: 101
  start-page: 2999
  year: 2003
  end-page: 3001
  ident: bib0275
  article-title: Mesenchymal stem cells distribute to a wide range of tissues following systemic infusion into nonhuman primates
  publication-title: Blood
– volume: 25
  start-page: 586
  year: 2016
  end-page: 597
  ident: bib0405
  article-title: Effects of freeze-thawing and intravenous infusion on mesenchymal stromal cell gene expression
  publication-title: Stem Cells Dev.
– volume: 4
  start-page: 62
  year: 2009
  end-page: 72
  ident: bib0295
  article-title: Differential mobilization of subsets of progenitor cells from the bone marrow
  publication-title: Cell Stem Cell
– volume: 36
  start-page: 1778
  year: 2018
  end-page: 1788
  ident: bib0125
  article-title: Intravenous infusion of human adipose mesenchymal stem cells modifies the host response to lipopolysaccharide in humans: a randomized, single-blind, parallel group, placebo controlled trial
  publication-title: Stem Cells
– volume: 3
  start-page: 301
  year: 2008
  end-page: 313
  ident: bib0165
  article-title: A perivascular origin for mesenchymal stem cells in multiple human organs
  publication-title: Cell Stem Cell
– volume: 89
  start-page: 465
  year: 2010
  end-page: 471
  ident: bib0235
  article-title: Insulin-heparin infusions peritransplant substantially improve single-donor clinical islet transplant success
  publication-title: Transplantation
– volume: 25
  start-page: 1830
  year: 2007
  end-page: 1839
  ident: bib0250
  article-title: Circulating connective tissue precursors: extreme rarity in humans and chondrogenic potential in guinea pigs
  publication-title: Stem Cells
– volume: 8
  start-page: 1421
  year: 2018
  end-page: 1434
  ident: bib0115
  article-title: Selection of tissue factor-deficient cell transplants as a novel strategy for improving hemocompatibility of human bone marrow stromal cells
  publication-title: Theranostics
– volume: 343
  start-page: 230
  year: 2000
  end-page: 238
  ident: bib0225
  article-title: Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen
  publication-title: N. Engl. J. Med.
– volume: 16
  start-page: 203
  year: 2010
  end-page: 209
  ident: bib0015
  article-title: Mesenchymal stem cell therapy: two steps forward, one step back
  publication-title: Trends Mol. Med.
– volume: 53
  start-page: 502
  year: 2015
  end-page: 521
  ident: bib0480
  article-title: Biomaterials based strategies for skeletal muscle tissue engineering: existing technologies and future trends
  publication-title: Biomaterials
– volume: 14
  start-page: 141
  year: 2014
  end-page: 145
  ident: bib0010
  article-title: MSC-based product characterization for clinical trials: an FDA perspective
  publication-title: Cell Stem Cell
– volume: 9
  start-page: 184
  year: 2018
  ident: bib0450
  article-title: Human mesenchymal stromal cells inhibit platelet activation and aggregation involving CD73-converted adenosine
  publication-title: Stem Cell Res. Ther.
– volume: 275
  start-page: 964
  year: 1997
  end-page: 967
  ident: bib0285
  article-title: Isolation of putative progenitor endothelial cells for angiogenesis
  publication-title: Science
– volume: 32
  start-page: 2430
  year: 2014
  end-page: 2442
  ident: bib0200
  article-title: Do cryopreserved mesenchymal stromal cells display impaired immunomodulatory and therapeutic properties?
  publication-title: Stem Cells
– volume: 25
  start-page: 2511
  year: 2007
  end-page: 2523
  ident: bib0175
  article-title: Functional network analysis of the transcriptomes of mesenchymal stem cells derived from amniotic fluid, amniotic membrane, cord blood, and bone marrow
  publication-title: Stem Cells
– volume: 21
  start-page: 1809
  year: 2015
  end-page: 1816
  ident: bib0390
  article-title: Human placenta-derived cells (PDA-001) for the treatment of moderate-to-severe Crohn’s disease: a Phase 1b/2a study
  publication-title: Inflamm. Bowel Dis.
– volume: 563
  start-page: 347
  year: 2018
  end-page: 353
  ident: bib0190
  article-title: Single-cell reconstruction of the early maternal-fetal interface in humans
  publication-title: Nature
– volume: 7
  start-page: 731
  year: 2018
  end-page: 739
  ident: bib0065
  article-title: Clinical cellular therapeutics accelerate clot formation
  publication-title: Stem Cells Transl. Med.
– volume: 49
  start-page: 1656
  year: 2017
  end-page: 1658
  ident: bib0060
  article-title: Thromboembolism induced by umbilical cord mesenchymal stem cell infusion: a report of two cases and literature review
  publication-title: Transplant. Proc.
– volume: 431
  start-page: 203
  year: 2013
  end-page: 209
  ident: bib0090
  article-title: Tissue factor triggers procoagulation in transplanted mesenchymal stem cells leading to thromboembolism
  publication-title: Biochem. Biophys. Res. Commun.
– volume: 452
  start-page: 442
  year: 2008
  end-page: 447
  ident: bib0315
  article-title: Haematopoietic stem cell release is regulated by circadian oscillations
  publication-title: Nature
– volume: 9
  year: 2014
  ident: bib0430
  article-title: Do ABO blood group antigens hamper the therapeutic efficacy of mesenchymal stromal cells?
  publication-title: PLoS One
– volume: 48
  start-page: 1907
  year: 1999
  end-page: 1914
  ident: bib0270
  article-title: Incompatibility between human blood and isolated islets of Langerhans: a finding with implications for clinical intraportal islet transplantation?
  publication-title: Diabetes
– volume: 2
  start-page: 313
  year: 2008
  end-page: 319
  ident: bib0170
  article-title: Mesenchymal stem cells: revisiting history, concepts, and assays
  publication-title: Cell Stem Cell
– volume: 376
  start-page: 1007
  year: 2017
  end-page: 1009
  ident: bib0045
  article-title: Clarifying stem-cell therapy’s benefits and risks
  publication-title: N. Engl. J. Med.
– volume: 7
  start-page: 106
  year: 2017
  end-page: 116
  ident: bib0120
  article-title: Heparin improves BMSC cell therapy: anticoagulant treatment by heparin improves the safety and therapeutic effect of bone marrow-derived mesenchymal stem cell cytotherapy
  publication-title: Theranostics
– volume: 99
  start-page: 8932
  year: 2002
  end-page: 8937
  ident: bib0160
  article-title: Isolated allogeneic bone marrow-derived mesenchymal cells engraft and stimulate growth in children with osteogenesis imperfecta: implications for cell therapy of bone
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
– volume: 26
  start-page: 300
  year: 2008
  end-page: 311
  ident: bib0180
  article-title: Concise review: isolation and characterization of cells from human term placenta: outcome of the first international Workshop on Placenta Derived Stem Cells
  publication-title: Stem Cells
– volume: 4
  start-page: 206
  year: 2009
  end-page: 216
  ident: bib0245
  article-title: Mesenchymal stem cell homing: the devil is in the details
  publication-title: Cell Stem Cell
– volume: 62
  start-page: 4266
  year: 2013
  end-page: 4269
  ident: bib0410
  article-title: Adipose mesenchymal stromal cells isolated from type 2 diabetic patients display reduced fibrinolytic activity
  publication-title: Diabetes
– volume: 47
  start-page: 315
  year: 1996
  end-page: 331
  ident: bib0340
  article-title: Role of endothelium in thrombosis and hemostasis
  publication-title: Annu. Rev. Med.
– volume: 30
  start-page: 2472
  year: 2012
  end-page: 2486
  ident: bib0335
  article-title: Mesenchymal stem cells transmigrate between and directly through tumor necrosis factor-alpha-activated endothelial cells via both leukocyte-like and novel mechanisms
  publication-title: Stem Cells
– volume: 47
  start-page: 126
  year: 2008
  end-page: 131
  ident: bib0260
  article-title: Human bone marrow mesenchymal stem cells
  publication-title: Rheumatology (Oxford)
– volume: 7
  start-page: 325
  year: 2018
  end-page: 331
  ident: bib0195
  article-title: Placenta-derived decidua stromal cells for treatment of severe acute graft-versus-host disease
  publication-title: Stem Cells Transl. Med.
– volume: 865
  start-page: 3
  year: 2015
  end-page: 17
  ident: bib0265
  article-title: Thromboinflammation in therapeutic medicine
  publication-title: Adv. Exp. Med. Biol.
– volume: 11
  start-page: 166
  year: 2014
  end-page: 176
  ident: bib0470
  article-title: Liver support strategies: cutting-edge technologies
  publication-title: Nat. Rev. Gastroenterol. Hepatol.
– volume: 3
  start-page: 1119
  year: 2018
  end-page: 1127
  ident: bib0475
  article-title: Extracorporeal stromal cell therapy for subjects with dialysis-dependent acute kidney injury
  publication-title: Kidney Int. Rep.
– volume: 30
  start-page: 1575
  year: 2012
  end-page: 1578
  ident: bib0150
  article-title: Analysis of tissues following mesenchymal stromal cell therapy in humans indicates limited long-term engraftment and no ectopic tissue formation
  publication-title: Stem Cells
– volume: 76
  start-page: 86
  year: 1990
  end-page: 96
  ident: bib0215
  article-title: Tissue factor: identification and characterization of cell types in human placentae
  publication-title: Blood
– volume: 466
  start-page: 829
  year: 2010
  end-page: 834
  ident: bib0290
  article-title: Mesenchymal and haematopoietic stem cells form a unique bone marrow niche
  publication-title: Nature
– volume: 104
  start-page: 398
  year: 2009
  end-page: 402
  ident: bib0080
  article-title: Fate of culture-expanded mesenchymal stem cells in the microvasculature:
  publication-title: Circ. Res.
– volume: 7
  year: 2012
  ident: bib0085
  article-title: Bivalirudin in combination with heparin to control mesenchymal cell procoagulant activity
  publication-title: PLoS One
– volume: 19
  start-page: 35
  year: 2013
  end-page: 42
  ident: bib0025
  article-title: The meaning, the sense and the significance: translating the science of mesenchymal stem cells into medicine
  publication-title: Nat. Med.
– volume: 25
  start-page: 2511
  year: 2007
  ident: 10.1016/j.molmed.2018.12.006_bib0175
  article-title: Functional network analysis of the transcriptomes of mesenchymal stem cells derived from amniotic fluid, amniotic membrane, cord blood, and bone marrow
  publication-title: Stem Cells
  doi: 10.1634/stemcells.2007-0023
– volume: 7
  start-page: 590
  year: 2011
  ident: 10.1016/j.molmed.2018.12.006_bib0300
  article-title: The ins and outs of hematopoietic stem cells: studies to improve transplantation outcomes
  publication-title: Stem Cell Rev.
  doi: 10.1007/s12015-010-9212-8
– volume: 10
  start-page: 357
  year: 2015
  ident: 10.1016/j.molmed.2018.12.006_bib0455
  article-title: Engineering more efficient multipotent mesenchymal stromal (stem) cells for systemic delivery as cellular therapy
  publication-title: ISBT Sci. Ser.
  doi: 10.1111/voxs.12133
– volume: 4
  start-page: 206
  year: 2009
  ident: 10.1016/j.molmed.2018.12.006_bib0245
  article-title: Mesenchymal stem cell homing: the devil is in the details
  publication-title: Cell Stem Cell
  doi: 10.1016/j.stem.2009.02.001
– volume: 7
  start-page: 731
  year: 2018
  ident: 10.1016/j.molmed.2018.12.006_bib0065
  article-title: Clinical cellular therapeutics accelerate clot formation
  publication-title: Stem Cells Transl. Med.
  doi: 10.1002/sctm.18-0015
– volume: 101
  start-page: 2999
  year: 2003
  ident: 10.1016/j.molmed.2018.12.006_bib0275
  article-title: Mesenchymal stem cells distribute to a wide range of tissues following systemic infusion into nonhuman primates
  publication-title: Blood
  doi: 10.1182/blood-2002-06-1830
– volume: 54
  start-page: 1293
  year: 2013
  ident: 10.1016/j.molmed.2018.12.006_bib0055
  article-title: Familial occurrence of pulmonary embolism after intravenous, adipose tissue-derived stem cell therapy
  publication-title: Yonsei Med. J.
  doi: 10.3349/ymj.2013.54.5.1293
– volume: 18
  start-page: 151
  year: 2016
  ident: 10.1016/j.molmed.2018.12.006_bib0135
  article-title: International Society for Cellular Therapy perspective on immune functional assays for mesenchymal stromal cells as potency release criterion for advanced phase clinical trials
  publication-title: Cytotherapy
  doi: 10.1016/j.jcyt.2015.11.008
– volume: 120
  start-page: 3436
  year: 2012
  ident: 10.1016/j.molmed.2018.12.006_bib0350
  article-title: Mesenchymal stem cells are injured by complement after their contact with serum
  publication-title: Blood
  doi: 10.1182/blood-2012-03-420612
– volume: 7
  start-page: 106
  year: 2017
  ident: 10.1016/j.molmed.2018.12.006_bib0120
  article-title: Heparin improves BMSC cell therapy: anticoagulant treatment by heparin improves the safety and therapeutic effect of bone marrow-derived mesenchymal stem cell cytotherapy
  publication-title: Theranostics
  doi: 10.7150/thno.16911
– volume: 14
  start-page: 141
  year: 2014
  ident: 10.1016/j.molmed.2018.12.006_bib0010
  article-title: MSC-based product characterization for clinical trials: an FDA perspective
  publication-title: Cell Stem Cell
  doi: 10.1016/j.stem.2014.01.013
– volume: 47
  start-page: 315
  year: 1996
  ident: 10.1016/j.molmed.2018.12.006_bib0340
  article-title: Role of endothelium in thrombosis and hemostasis
  publication-title: Annu. Rev. Med.
  doi: 10.1146/annurev.med.47.1.315
– volume: 77
  start-page: 370
  year: 2009
  ident: 10.1016/j.molmed.2018.12.006_bib0075
  article-title: Is the intravascular administration of mesenchymal stem cells safe? Mesenchymal stem cells and intravital microscopy
  publication-title: Microvasc. Res.
  doi: 10.1016/j.mvr.2009.02.001
– volume: 466
  start-page: 829
  year: 2010
  ident: 10.1016/j.molmed.2018.12.006_bib0290
  article-title: Mesenchymal and haematopoietic stem cells form a unique bone marrow niche
  publication-title: Nature
  doi: 10.1038/nature09262
– volume: 376
  start-page: 1007
  year: 2017
  ident: 10.1016/j.molmed.2018.12.006_bib0045
  article-title: Clarifying stem-cell therapy’s benefits and risks
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMp1613723
– volume: 9
  start-page: 184
  year: 2018
  ident: 10.1016/j.molmed.2018.12.006_bib0450
  article-title: Human mesenchymal stromal cells inhibit platelet activation and aggregation involving CD73-converted adenosine
  publication-title: Stem Cell Res. Ther.
  doi: 10.1186/s13287-018-0936-8
– volume: 8
  start-page: 1421
  year: 2018
  ident: 10.1016/j.molmed.2018.12.006_bib0115
  article-title: Selection of tissue factor-deficient cell transplants as a novel strategy for improving hemocompatibility of human bone marrow stromal cells
  publication-title: Theranostics
  doi: 10.7150/thno.21906
– volume: 6
  year: 2011
  ident: 10.1016/j.molmed.2018.12.006_bib0310
  article-title: Mesenchymal stromal cells engage complement and complement receptor bearing innate effector cells to modulate immune responses
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0021703
– volume: 19
  start-page: 35
  year: 2013
  ident: 10.1016/j.molmed.2018.12.006_bib0025
  article-title: The meaning, the sense and the significance: translating the science of mesenchymal stem cells into medicine
  publication-title: Nat. Med.
  doi: 10.1038/nm.3028
– volume: 431
  start-page: 203
  year: 2013
  ident: 10.1016/j.molmed.2018.12.006_bib0090
  article-title: Tissue factor triggers procoagulation in transplanted mesenchymal stem cells leading to thromboembolism
  publication-title: Biochem. Biophys. Res. Commun.
  doi: 10.1016/j.bbrc.2012.12.134
– volume: 32
  start-page: 2430
  year: 2014
  ident: 10.1016/j.molmed.2018.12.006_bib0200
  article-title: Do cryopreserved mesenchymal stromal cells display impaired immunomodulatory and therapeutic properties?
  publication-title: Stem Cells
  doi: 10.1002/stem.1729
– volume: 11
  start-page: 785
  year: 2010
  ident: 10.1016/j.molmed.2018.12.006_bib0365
  article-title: Complement: a key system for immune surveillance and homeostasis
  publication-title: Nat. Immunol.
  doi: 10.1038/ni.1923
– volume: 30
  start-page: 2472
  year: 2012
  ident: 10.1016/j.molmed.2018.12.006_bib0335
  article-title: Mesenchymal stem cells transmigrate between and directly through tumor necrosis factor-alpha-activated endothelial cells via both leukocyte-like and novel mechanisms
  publication-title: Stem Cells
  doi: 10.1002/stem.1198
– volume: 9
  start-page: 2237
  year: 2018
  ident: 10.1016/j.molmed.2018.12.006_bib0370
  article-title: Interpretation of serological complement biomarkers in disease
  publication-title: Front. Immunol.
  doi: 10.3389/fimmu.2018.02237
– volume: 4
  start-page: 62
  year: 2009
  ident: 10.1016/j.molmed.2018.12.006_bib0295
  article-title: Differential mobilization of subsets of progenitor cells from the bone marrow
  publication-title: Cell Stem Cell
  doi: 10.1016/j.stem.2008.10.017
– volume: 24
  start-page: 2269
  year: 2015
  ident: 10.1016/j.molmed.2018.12.006_bib0100
  article-title: Different procoagulant activity of therapeutic mesenchymal stromal cells derived from bone marrow and placental decidua
  publication-title: Stem Cells Dev.
  doi: 10.1089/scd.2015.0120
– volume: 865
  start-page: 3
  year: 2015
  ident: 10.1016/j.molmed.2018.12.006_bib0265
  article-title: Thromboinflammation in therapeutic medicine
  publication-title: Adv. Exp. Med. Biol.
  doi: 10.1007/978-3-319-18603-0_1
– volume: 104
  start-page: 398
  year: 2009
  ident: 10.1016/j.molmed.2018.12.006_bib0080
  article-title: Fate of culture-expanded mesenchymal stem cells in the microvasculature: in vivo observations of cell kinetics
  publication-title: Circ. Res.
  doi: 10.1161/CIRCRESAHA.108.187724
– volume: 360
  start-page: 2039
  year: 2002
  ident: 10.1016/j.molmed.2018.12.006_bib0220
  article-title: Production of tissue factor by pancreatic islet cells as a trigger of detrimental thrombotic reactions in clinical islet transplantation
  publication-title: Lancet
  doi: 10.1016/S0140-6736(02)12020-4
– volume: 26
  start-page: 71
  year: 2017
  ident: 10.1016/j.molmed.2018.12.006_bib0445
  article-title: Control of IBMIR induced by fresh and cryopreserved hepatocytes by low molecular weight dextran sulfate versus heparin
  publication-title: Cell Transplant.
  doi: 10.3727/096368916X692609
– volume: 50
  start-page: 710
  year: 2001
  ident: 10.1016/j.molmed.2018.12.006_bib0230
  article-title: Clinical outcomes and insulin secretion after islet transplantation with the Edmonton protocol
  publication-title: Diabetes
  doi: 10.2337/diabetes.50.4.710
– volume: 36
  start-page: 312
  year: 2015
  ident: 10.1016/j.molmed.2018.12.006_bib0185
  article-title: Mesenchymal stem cells reside in a vascular niche in the decidua basalis and are absent in remodelled spiral arterioles
  publication-title: Placenta
  doi: 10.1016/j.placenta.2014.12.014
– volume: 28
  start-page: e21
  year: 2008
  ident: 10.1016/j.molmed.2018.12.006_bib0320
  article-title: Circulating endothelial progenitor cells exhibit diurnal variation
  publication-title: Arterioscler. Thromb. Vasc. Biol.
  doi: 10.1161/ATVBAHA.107.160317
– volume: 36
  start-page: 1778
  year: 2018
  ident: 10.1016/j.molmed.2018.12.006_bib0125
  article-title: Intravenous infusion of human adipose mesenchymal stem cells modifies the host response to lipopolysaccharide in humans: a randomized, single-blind, parallel group, placebo controlled trial
  publication-title: Stem Cells
  doi: 10.1002/stem.2891
– volume: 452
  start-page: 442
  year: 2008
  ident: 10.1016/j.molmed.2018.12.006_bib0315
  article-title: Haematopoietic stem cell release is regulated by circadian oscillations
  publication-title: Nature
  doi: 10.1038/nature06685
– volume: 182
  start-page: 3827
  year: 2009
  ident: 10.1016/j.molmed.2018.12.006_bib0305
  article-title: C3a and C5a are chemotactic factors for human mesenchymal stem cells, which cause prolonged ERK1/2 phosphorylation
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.0803055
– volume: 28
  start-page: 1634
  year: 2010
  ident: 10.1016/j.molmed.2018.12.006_bib0330
  article-title: Circulating plastic adherent mesenchymal stem cells in aged hip fracture patients
  publication-title: J. Orthop. Res.
  doi: 10.1002/jor.21167
– volume: 102
  start-page: 209
  year: 2016
  ident: 10.1016/j.molmed.2018.12.006_bib0490
  article-title: Painting factor H onto mesenchymal stem cells protects the cells from complement- and neutrophil-mediated damage
  publication-title: Biomaterials
  doi: 10.1016/j.biomaterials.2016.05.055
– volume: 47
  start-page: 126
  year: 2008
  ident: 10.1016/j.molmed.2018.12.006_bib0260
  article-title: Human bone marrow mesenchymal stem cells in vivo
  publication-title: Rheumatology (Oxford)
  doi: 10.1093/rheumatology/kem206
– volume: 33
  start-page: 2726
  year: 2015
  ident: 10.1016/j.molmed.2018.12.006_bib0095
  article-title: Bone marrow-derived mesenchymal stem cells have innate procoagulant activity and cause microvascular obstruction following intracoronary delivery: amelioration by antithrombin therapy
  publication-title: Stem Cells
  doi: 10.1002/stem.2050
– volume: 23
  start-page: 2328
  year: 2014
  ident: 10.1016/j.molmed.2018.12.006_bib0325
  article-title: No evidence for circulating mesenchymal stem cells in patients with organ injury
  publication-title: Stem Cells Dev.
  doi: 10.1089/scd.2014.0269
– volume: 134
  start-page: 1087
  year: 1989
  ident: 10.1016/j.molmed.2018.12.006_bib0210
  article-title: Selective cellular expression of tissue factor in human tissues. Implications for disorders of hemostasis and thrombosis
  publication-title: Am. J. Pathol.
– volume: 9
  year: 2014
  ident: 10.1016/j.molmed.2018.12.006_bib0430
  article-title: Do ABO blood group antigens hamper the therapeutic efficacy of mesenchymal stromal cells?
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0085040
– volume: 8
  year: 2013
  ident: 10.1016/j.molmed.2018.12.006_bib0485
  article-title: Mesenchymal stem cells engineered to inhibit complement-mediated damage
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0060461
– volume: 76
  start-page: 86
  year: 1990
  ident: 10.1016/j.molmed.2018.12.006_bib0215
  article-title: Tissue factor: identification and characterization of cell types in human placentae
  publication-title: Blood
  doi: 10.1182/blood.V76.1.86.86
– volume: 53
  start-page: 502
  year: 2015
  ident: 10.1016/j.molmed.2018.12.006_bib0480
  article-title: Biomaterials based strategies for skeletal muscle tissue engineering: existing technologies and future trends
  publication-title: Biomaterials
  doi: 10.1016/j.biomaterials.2015.02.110
– volume: 284
  start-page: 143
  year: 1999
  ident: 10.1016/j.molmed.2018.12.006_bib0145
  article-title: Multilineage potential of adult human mesenchymal stem cells
  publication-title: Science
  doi: 10.1126/science.284.5411.143
– volume: 4
  start-page: 48
  year: 2013
  ident: 10.1016/j.molmed.2018.12.006_bib0440
  article-title: Safety and efficacy of intravenous infusion of allogeneic cryopreserved mesenchymal stem cells for treatment of chronic kidney disease in cats: results of three sequential pilot studies
  publication-title: Stem Cell Res. Ther.
  doi: 10.1186/scrt198
– volume: 16
  start-page: 203
  year: 2010
  ident: 10.1016/j.molmed.2018.12.006_bib0015
  article-title: Mesenchymal stem cell therapy: two steps forward, one step back
  publication-title: Trends Mol. Med.
  doi: 10.1016/j.molmed.2010.02.005
– volume: 2
  start-page: 313
  year: 2008
  ident: 10.1016/j.molmed.2018.12.006_bib0170
  article-title: Mesenchymal stem cells: revisiting history, concepts, and assays
  publication-title: Cell Stem Cell
  doi: 10.1016/j.stem.2008.03.002
– volume: 468
  start-page: 485
  year: 2010
  ident: 10.1016/j.molmed.2018.12.006_bib0050
  article-title: Korean deaths spark inquiry
  publication-title: Nature
  doi: 10.1038/468485a
– volume: 26
  start-page: 2696
  year: 2018
  ident: 10.1016/j.molmed.2018.12.006_bib0420
  article-title: PDGF restores the defective phenotype of adipose-derived mesenchymal stromal cells from diabetic patients
  publication-title: Mol. Ther.
  doi: 10.1016/j.ymthe.2018.08.011
– volume: 25
  start-page: 1830
  year: 2007
  ident: 10.1016/j.molmed.2018.12.006_bib0250
  article-title: Circulating connective tissue precursors: extreme rarity in humans and chondrogenic potential in guinea pigs
  publication-title: Stem Cells
  doi: 10.1634/stemcells.2007-0140
– volume: 8
  start-page: 315
  year: 2006
  ident: 10.1016/j.molmed.2018.12.006_bib0130
  article-title: Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement
  publication-title: Cytotherapy
  doi: 10.1080/14653240600855905
– volume: 5
  start-page: 309
  year: 1999
  ident: 10.1016/j.molmed.2018.12.006_bib0155
  article-title: Transplantability and therapeutic effects of bone marrow-derived mesenchymal cells in children with osteogenesis imperfecta
  publication-title: Nat. Med.
  doi: 10.1038/6529
– volume: 18
  start-page: 683
  year: 2009
  ident: 10.1016/j.molmed.2018.12.006_bib0280
  article-title: Pulmonary passage is a major obstacle for intravenous stem cell delivery: the pulmonary first-pass effect
  publication-title: Stem Cells Dev.
  doi: 10.1089/scd.2008.0253
– volume: 28
  start-page: 184
  year: 2007
  ident: 10.1016/j.molmed.2018.12.006_bib0360
  article-title: Complement and coagulation: strangers or partners in crime?
  publication-title: Trends Immunol.
  doi: 10.1016/j.it.2007.02.006
– volume: 343
  start-page: 230
  year: 2000
  ident: 10.1016/j.molmed.2018.12.006_bib0225
  article-title: Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJM200007273430401
– volume: 25
  start-page: 69
  year: 2007
  ident: 10.1016/j.molmed.2018.12.006_bib0255
  article-title: Concise review: multipotent mesenchymal stromal cells in blood
  publication-title: Stem Cells
  doi: 10.1634/stemcells.2006-0335
– volume: 3
  start-page: 696
  year: 2014
  ident: 10.1016/j.molmed.2018.12.006_bib0385
  article-title: Human placenta-derived cells (PDA-001) for the treatment of adults with multiple sclerosis: a randomized, placebo-controlled, multiple-dose study
  publication-title: Multi Scler. Relat. Disord.
  doi: 10.1016/j.msard.2014.08.002
– volume: 30
  start-page: 1575
  year: 2012
  ident: 10.1016/j.molmed.2018.12.006_bib0150
  article-title: Analysis of tissues following mesenchymal stromal cell therapy in humans indicates limited long-term engraftment and no ectopic tissue formation
  publication-title: Stem Cells
  doi: 10.1002/stem.1118
– volume: 6
  start-page: 1786
  year: 2017
  ident: 10.1016/j.molmed.2018.12.006_bib0415
  article-title: Concise review: a safety assessment of adipose-derived cell therapy in clinical trials: a systematic review of reported adverse events
  publication-title: Stem Cells Transl. Med.
  doi: 10.1002/sctm.17-0031
– volume: 12
  start-page: 260
  year: 2010
  ident: 10.1016/j.molmed.2018.12.006_bib0435
  article-title: Suspension medium influences interaction of mesenchymal stromal cells with endothelium and pulmonary toxicity after transplantation in mice
  publication-title: Cytotherapy
  doi: 10.3109/14653240903401840
– volume: 9
  start-page: 312
  year: 2018
  ident: 10.1016/j.molmed.2018.12.006_bib0400
  article-title: Safety analysis in patients with autoimmune disease receiving allogeneic mesenchymal stem cells infusion: a long-term retrospective study
  publication-title: Stem Cell Res. Ther.
  doi: 10.1186/s13287-018-1053-4
– volume: 31
  start-page: 2033
  year: 2013
  ident: 10.1016/j.molmed.2018.12.006_bib0030
  article-title: Concise review: adult mesenchymal stromal cell therapy for inflammatory diseases: how well are we joining the dots?
  publication-title: Stem Cells
  doi: 10.1002/stem.1452
– volume: 21
  start-page: 1809
  year: 2015
  ident: 10.1016/j.molmed.2018.12.006_bib0390
  article-title: Human placenta-derived cells (PDA-001) for the treatment of moderate-to-severe Crohn’s disease: a Phase 1b/2a study
  publication-title: Inflamm. Bowel Dis.
  doi: 10.1097/MIB.0000000000000441
– volume: 563
  start-page: 347
  year: 2018
  ident: 10.1016/j.molmed.2018.12.006_bib0190
  article-title: Single-cell reconstruction of the early maternal-fetal interface in humans
  publication-title: Nature
  doi: 10.1038/s41586-018-0698-6
– volume: 11
  start-page: 166
  year: 2014
  ident: 10.1016/j.molmed.2018.12.006_bib0470
  article-title: Liver support strategies: cutting-edge technologies
  publication-title: Nat. Rev. Gastroenterol. Hepatol.
  doi: 10.1038/nrgastro.2013.204
– volume: 275
  start-page: 964
  year: 1997
  ident: 10.1016/j.molmed.2018.12.006_bib0285
  article-title: Isolation of putative progenitor endothelial cells for angiogenesis
  publication-title: Science
  doi: 10.1126/science.275.5302.964
– volume: 22
  start-page: 824
  year: 2018
  ident: 10.1016/j.molmed.2018.12.006_bib0005
  article-title: Mesenchymal stromal cells: clinical challenges and therapeutic opportunities
  publication-title: Cell Stem Cell
  doi: 10.1016/j.stem.2018.05.004
– volume: 3
  start-page: e45
  year: 2016
  ident: 10.1016/j.molmed.2018.12.006_bib0375
  article-title: Survival after mesenchymal stromal cell therapy in steroid-refractory acute graft-versus-host disease: systematic review and meta-analysis
  publication-title: Lancet Haematol.
  doi: 10.1016/S2352-3026(15)00224-0
– volume: 3
  start-page: 1119
  year: 2018
  ident: 10.1016/j.molmed.2018.12.006_bib0475
  article-title: Extracorporeal stromal cell therapy for subjects with dialysis-dependent acute kidney injury
  publication-title: Kidney Int. Rep.
  doi: 10.1016/j.ekir.2018.05.009
– volume: 139
  start-page: 106
  year: 2018
  ident: 10.1016/j.molmed.2018.12.006_bib0465
  article-title: Placenta-derived decidua stromal cells for hemorrhagic cystitis after stem cell transplantation
  publication-title: Acta Haematol.
  doi: 10.1159/000485735
– volume: 26
  start-page: 297
  year: 2016
  ident: 10.1016/j.molmed.2018.12.006_bib0205
  article-title: Tissue factor as a link between inflammation and coagulation
  publication-title: Trends Cardiovasc. Med.
  doi: 10.1016/j.tcm.2015.12.001
– volume: 32
  start-page: 252
  year: 2014
  ident: 10.1016/j.molmed.2018.12.006_bib0020
  article-title: Mesenchymal stem cells: immune evasive, not immune privileged
  publication-title: Nat. Biotechnol.
  doi: 10.1038/nbt.2816
– volume: 8
  start-page: 795
  year: 2017
  ident: 10.1016/j.molmed.2018.12.006_bib0395
  article-title: Safety and side effects of using placenta-derived decidual stromal cells for graft-versus-host disease and hemorrhagic cystitis
  publication-title: Front. Immunol.
  doi: 10.3389/fimmu.2017.00795
– volume: 951
  start-page: 77
  year: 2016
  ident: 10.1016/j.molmed.2018.12.006_bib0460
  article-title: Cryopreserved or fresh mesenchymal stromal cells: only a matter of taste or key to unleash the full clinical potential of MSC therapy?
  publication-title: Adv. Exp. Med. Biol.
  doi: 10.1007/978-3-319-45457-3_7
– volume: 7
  start-page: 325
  year: 2018
  ident: 10.1016/j.molmed.2018.12.006_bib0195
  article-title: Placenta-derived decidua stromal cells for treatment of severe acute graft-versus-host disease
  publication-title: Stem Cells Transl. Med.
  doi: 10.1002/sctm.17-0167
– volume: 7
  year: 2012
  ident: 10.1016/j.molmed.2018.12.006_bib0040
  article-title: Safety of cell therapy with mesenchymal stromal cells (SafeCell): a systematic review and meta-analysis of clinical trials
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0047559
– volume: 45
  start-page: 1353
  year: 2015
  ident: 10.1016/j.molmed.2018.12.006_bib0105
  article-title: Enhanced survival of mice infused with bone marrow-derived as compared with adipose-derived mesenchymal stem cells
  publication-title: Hepatol. Res.
  doi: 10.1111/hepr.12507
– volume: 17
  start-page: 331
  year: 1974
  ident: 10.1016/j.molmed.2018.12.006_bib0140
  article-title: Stromal cells responsible for transferring the microenvironment of the hemopoietic tissues. Cloning in vitro and retransplantation in vivo
  publication-title: Transplantation
  doi: 10.1097/00007890-197404000-00001
– volume: 5
  start-page: 1485
  year: 2016
  ident: 10.1016/j.molmed.2018.12.006_bib0425
  article-title: Type 1 diabetes mellitus donor mesenchymal stromal cells exhibit comparable potency to healthy controls in vitro
  publication-title: Stem Cells Transl. Med.
  doi: 10.5966/sctm.2015-0272
– volume: 48
  start-page: 1907
  year: 1999
  ident: 10.1016/j.molmed.2018.12.006_bib0270
  article-title: Incompatibility between human blood and isolated islets of Langerhans: a finding with implications for clinical intraportal islet transplantation?
  publication-title: Diabetes
  doi: 10.2337/diabetes.48.10.1907
– volume: 31
  start-page: 32
  year: 2010
  ident: 10.1016/j.molmed.2018.12.006_bib0240
  article-title: Can cells and biomaterials in therapeutic medicine be shielded from innate immune recognition?
  publication-title: Trends Immunol.
  doi: 10.1016/j.it.2009.09.005
– volume: 114
  start-page: 1037
  year: 2004
  ident: 10.1016/j.molmed.2018.12.006_bib0345
  article-title: Endothelial cell culture: beginnings of modern vascular biology
  publication-title: J. Clin. Invest.
  doi: 10.1172/JCI23284
– volume: 3
  start-page: 301
  year: 2008
  ident: 10.1016/j.molmed.2018.12.006_bib0165
  article-title: A perivascular origin for mesenchymal stem cells in multiple human organs
  publication-title: Cell Stem Cell
  doi: 10.1016/j.stem.2008.07.003
– volume: 83
  start-page: S164
  year: 2017
  ident: 10.1016/j.molmed.2018.12.006_bib0110
  article-title: Procoagulant activity of human mesenchymal stem cells
  publication-title: J. Trauma Acute Care Surg.
  doi: 10.1097/TA.0000000000001485
– volume: 26
  start-page: 300
  year: 2008
  ident: 10.1016/j.molmed.2018.12.006_bib0180
  article-title: Concise review: isolation and characterization of cells from human term placenta: outcome of the first international Workshop on Placenta Derived Stem Cells
  publication-title: Stem Cells
  doi: 10.1634/stemcells.2007-0594
– volume: 62
  start-page: 4266
  year: 2013
  ident: 10.1016/j.molmed.2018.12.006_bib0410
  article-title: Adipose mesenchymal stromal cells isolated from type 2 diabetic patients display reduced fibrinolytic activity
  publication-title: Diabetes
  doi: 10.2337/db13-0896
– volume: 49
  start-page: 1656
  year: 2017
  ident: 10.1016/j.molmed.2018.12.006_bib0060
  article-title: Thromboembolism induced by umbilical cord mesenchymal stem cell infusion: a report of two cases and literature review
  publication-title: Transplant. Proc.
  doi: 10.1016/j.transproceed.2017.03.078
– volume: 363
  start-page: 783
  year: 2004
  ident: 10.1016/j.molmed.2018.12.006_bib0070
  article-title: Intra-coronary arterial injection of mesenchymal stromal cells and microinfarction in dogs
  publication-title: Lancet
  doi: 10.1016/S0140-6736(04)15695-X
– volume: 99
  start-page: 8932
  year: 2002
  ident: 10.1016/j.molmed.2018.12.006_bib0160
  article-title: Isolated allogeneic bone marrow-derived mesenchymal cells engraft and stimulate growth in children with osteogenesis imperfecta: implications for cell therapy of bone
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
  doi: 10.1073/pnas.132252399
– volume: 7
  year: 2012
  ident: 10.1016/j.molmed.2018.12.006_bib0085
  article-title: Bivalirudin in combination with heparin to control mesenchymal cell procoagulant activity
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0042819
– volume: 113
  start-page: 722
  year: 2006
  ident: 10.1016/j.molmed.2018.12.006_bib0355
  article-title: Tissue factor in cardiovascular diseases: molecular mechanisms and clinical implications
  publication-title: Circulation
  doi: 10.1161/CIRCULATIONAHA.105.567297
– volume: 25
  start-page: 586
  year: 2016
  ident: 10.1016/j.molmed.2018.12.006_bib0405
  article-title: Effects of freeze-thawing and intravenous infusion on mesenchymal stromal cell gene expression
  publication-title: Stem Cells Dev.
  doi: 10.1089/scd.2015.0329
– volume: 24
  start-page: 1665
  year: 2016
  ident: 10.1016/j.molmed.2018.12.006_bib0495
  article-title: Local inhibition of complement improves mesenchymal stem cell viability and function after administration
  publication-title: Mol. Ther.
  doi: 10.1038/mt.2016.142
– volume: 89
  start-page: 465
  year: 2010
  ident: 10.1016/j.molmed.2018.12.006_bib0235
  article-title: Insulin-heparin infusions peritransplant substantially improve single-donor clinical islet transplant success
  publication-title: Transplantation
  doi: 10.1097/TP.0b013e3181c478fd
– volume: 3
  start-page: e12
  year: 2015
  ident: 10.1016/j.molmed.2018.12.006_bib0380
  article-title: Mesenchymal stem (stromal) cells for treatment of acute respiratory distress syndrome
  publication-title: Lancet Respir. Med.
  doi: 10.1016/S2213-2600(15)00047-8
– volume: 30
  start-page: 1565
  year: 2012
  ident: 10.1016/j.molmed.2018.12.006_bib0035
  article-title: Are therapeutic human mesenchymal stromal cells compatible with human blood?
  publication-title: Stem Cells
  doi: 10.1002/stem.1111
SSID ssj0015778
Score 2.6663802
SecondaryResourceType review_article
Snippet Intravascular infusion is the most popular route for therapeutic multipotent mesenchymal stromal/stem cell (MSC) delivery in hundreds of clinical trials....
SourceID swepub
proquest
pubmed
crossref
elsevier
SourceType Open Access Repository
Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 149
SubjectTerms Animals
CD142
cellular therapy
Clinical Trials as Topic
hemocompatibility
Humans
Inflammation - etiology
Inflammation - immunology
Mesenchymal Stem Cell Transplantation - adverse effects
Mesenchymal Stem Cell Transplantation - methods
Mesenchymal Stem Cells - cytology
Mesenchymal Stem Cells - immunology
mesenchymal stromal/stem cell
safety and efficacy
Thromboplastin - analysis
Thromboplastin - immunology
tissue factor
tissue source
Title Intravascular Mesenchymal Stromal/Stem Cell Therapy Product Diversification: Time for New Clinical Guidelines
URI https://www.clinicalkey.com/#!/content/1-s2.0-S1471491418302405
https://dx.doi.org/10.1016/j.molmed.2018.12.006
https://www.ncbi.nlm.nih.gov/pubmed/30711482
https://www.proquest.com/docview/2179519580
http://kipublications.ki.se/Default.aspx?queryparsed=id:140276056
Volume 25
WOSCitedRecordID wos000458294300010&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
journalDatabaseRights – providerCode: PRVESC
  databaseName: Elsevier SD Freedom Collection Journals 2021
  customDbUrl:
  eissn: 1471-499X
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0015778
  issn: 1471-4914
  databaseCode: AIEXJ
  dateStart: 20010101
  isFulltext: true
  titleUrlDefault: https://www.sciencedirect.com
  providerName: Elsevier
link http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1bb9MwFLZKB4gXBONWLpOREC9TSpImsc1bqTYYohPShtS3KBdH7dakU9dOG3-NP8c5viRdK7SBxEsUuXWa9HzxObbP9x1C3nHBUulFiZN4CW4zwkHkqXBkkQuesV7KC6Uz-40dHvLRSHxvtX5ZLszFlFUVv7wUZ__V1NAGxkbq7F-Yu74oNMA5GB2OYHY43srwB7hcWyeYDpFdlI2vykTtQM9KFPjfP1rIcncgVd1OpSqAhAFUfoUhUOVpFJMm7QNZIiobEXMhB5ZJ-XmJAlmYNL8a3zYptqWtu7uxfT-c6a0OvMKsWYY4neuSyypvd7ffrV1BUo4ncuwMJ9OfltHdQPrTRKaJHtIbXptZxUDi1LWMkJpe0-Qy4WgMntMJhGaZduVqm6q_Ww_hmjttoOqvjMee1kM1rt3TY-mG19ALGCfdElkgKB_rcbVG7K6JdCu3f4R3gDfloXRagPq5Wz4LBW-Trf7B3uhrvYkVMhUI1E9hmZsqvXDzt_4UGW3OfNZkbVUodPyIPDRzGNrX2HtMWrLaJvd0VdOrbXJ_aAz-hJTXwEhXwEgNGD8gFClCkRooUgNFugbFjxSBSAGIFIBILRBpA8Sn5Mf-3vHgi2MKfDgZWHDhpK70ZCHyRLg5k5Hbk0HGI4iril7OBfoLCNAly0XgyjBK8ywPRSphShP6YVLIrPeMtKtZJV8QCrOOIghEloqCB2lWiDBJfMajIvMY83K3Q3r2z40zo36PRVimsU1zPIm1SWI0Sez5MZikQ5y615lWf7nh-6G1W2yZzeCLYwDaDf1Y3c9EvjqivUXPtxYeMTgG3O1LKjlbnsc-uFolJQXP_lzjpn4GcOy4DuJ3yHsNpPoTVJs3TadwJuMA8wSil_98g6_Ig-Z9f03ai_lSviF3s4vF5Hy-Q-6wEd8xL85vNUf6zw
linkProvider Elsevier
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Intravascular+Mesenchymal+Stromal%2FStem+Cell+Therapy+Product+Diversification%3A+Time+for+New+Clinical+Guidelines&rft.jtitle=Trends+in+molecular+medicine&rft.au=Moll%2C+Guido&rft.au=Ankrum%2C+James+A.&rft.au=Kamhieh-Milz%2C+Julian&rft.au=Bieback%2C+Karen&rft.date=2019-02-01&rft.pub=Elsevier+Ltd&rft.issn=1471-4914&rft.eissn=1471-499X&rft.volume=25&rft.issue=2&rft.spage=149&rft.epage=163&rft_id=info:doi/10.1016%2Fj.molmed.2018.12.006&rft.externalDocID=S1471491418302405
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1471-4914&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1471-4914&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1471-4914&client=summon