Intravascular Mesenchymal Stromal/Stem Cell Therapy Product Diversification: Time for New Clinical Guidelines

Intravascular infusion is the most popular route for therapeutic multipotent mesenchymal stromal/stem cell (MSC) delivery in hundreds of clinical trials. Meta-analysis has demonstrated that bone marrow MSC infusion is safe. It is not clear if this also applies to diverse new cell products derived fr...

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Vydáno v:Trends in molecular medicine Ročník 25; číslo 2; s. 149 - 163
Hlavní autoři: Moll, Guido, Ankrum, James A., Kamhieh-Milz, Julian, Bieback, Karen, Ringdén, Olle, Volk, Hans-Dieter, Geissler, Sven, Reinke, Petra
Médium: Journal Article
Jazyk:angličtina
Vydáno: England Elsevier Ltd 01.02.2019
Témata:
Animals
CD142
cellular therapy
Clinical Trials as Topic
hemocompatibility
Humans
Inflammation - etiology
Inflammation - immunology
Mesenchymal Stem Cell Transplantation - adverse effects
Mesenchymal Stem Cell Transplantation - methods
Mesenchymal Stem Cells - cytology
Mesenchymal Stem Cells - immunology
mesenchymal stromal/stem cell
safety and efficacy
Thromboplastin - analysis
Thromboplastin - immunology
tissue factor
tissue source
CD142
hemocompatibility
tissue factor
safety and efficacy
cellular therapy
mesenchymal stromal/stem cell
tissue source
ISSN:1471-4914, 1471-499X, 1471-499X
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Shrnutí:Intravascular infusion is the most popular route for therapeutic multipotent mesenchymal stromal/stem cell (MSC) delivery in hundreds of clinical trials. Meta-analysis has demonstrated that bone marrow MSC infusion is safe. It is not clear if this also applies to diverse new cell products derived from other sources, such as adipose and perinatal tissues. Different MSC products display varying levels of highly procoagulant tissue factor (TF) and may adversely trigger the instant blood-mediated inflammatory reaction (IBMIR). Suitable strategies for assessing and controlling hemocompatibility and optimized cell delivery are crucial for the development of safer and more effective MSC therapies. MSC products have largely diversified during the past decade, making extrapolation about safety and efficacy from first-generation products inappropriate. MSCs and other blood non-resident cellular therapeutics display different degrees of incompatibility with human blood, which compromises their safety and efficacy. TF is the major determinant of cell product hemocompatibility, and this should be routinely monitored in all therapeutics intended for intravascular delivery. MSC products from different tissue sources display high variability in TF expression, with potential lethal consequences for patients when infused systemically. Once aware of the problem, a large array of product and process innovations became available to improve the clinical delivery of systemically infused cellular therapeutics.
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ISSN:1471-4914
1471-499X
1471-499X
DOI:10.1016/j.molmed.2018.12.006