Deficiency of IFNAR1 Increases the Production of Influenza Vaccine Viruses in MDCK Cells

Cell culture-based influenza vaccines exhibit comparable safety and immunogenicity to traditional egg-based vaccines. However, improving viral yield remains a key challenge in optimizing cell culture-based production systems. Madin–Darby canine kidney (MDCK) cells, the predominant cell line for infl...

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Bibliographic Details
Published in:	Viruses Vol. 17; no. 8; p. 1097
Main Authors:	Wang, Qi, Chen, Tuanjie, Feng, Mengru, Zheng, Mei, Gao, Feixia, Qiu, Chenchen, Luo, Jian, Li, Xiuling
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 08.08.2025 MDPI
Subjects:	Animals Antibodies Biological response modifiers Cell culture CRISPR CRISPR-Cas Systems CRISPR/Cas9 Dogs Down-regulation Ethylenediaminetetraacetic acid Gene Knockout Techniques Genes IFNAR1 Immunogenicity Infections Influenza Influenza A Virus, H1N1 Subtype - growth & development Influenza A Virus, H1N1 Subtype - immunology Influenza A Virus, H3N2 Subtype - immunology influenza vaccine Influenza vaccines Influenza Vaccines - immunology Interferon Madin Darby Canine Kidney Cells Manufacturing MDCK cells Microenvironments Plasmids Receptor, Interferon alpha-beta - deficiency Receptor, Interferon alpha-beta - genetics Replication Signal transduction Transcriptomics Vaccines Viral infections Virus Cultivation - methods Virus Replication Viruses United States China Beijing China United States > US Shanghai China influenza vaccine CRISPR/Cas9 MDCK cells interferon IFNAR1
ISSN:	1999-4915, 1999-4915
Online Access:	Get full text
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