Black Seed Thymoquinone Improved Insulin Secretion, Hepatic Glycogen Storage, and Oxidative Stress in Streptozotocin-Induced Diabetic Male Wistar Rats

Diabetes mellitus is one of the metabolic diseases having several complications. Nigella sativa oil (NSO) might have beneficial effects in the treatment of diabetic complications. Thirty-two mature male Wistar rats were equally divided into four experimental groups: control, control NSO 2 mL/kg, str...

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Published in:Oxidative medicine and cellular longevity Vol. 2018; no. 2018; pp. 1 - 10
Main Authors: Tag, Hend M., Muhammad, Muhammad A. A., Kilany, Omnia E., Abdelrazek, Heba M. A., Abdelazim, Aaser M.
Format: Journal Article
Language:English
Published: Cairo, Egypt Hindawi Publishing Corporation 01.01.2018
Hindawi
John Wiley & Sons, Inc
Subjects:
Animals
Antioxidants
Apolipoproteins
Benzoquinones - chemistry
Blood sugar
Cardiovascular disease
Cholesterol
Complications and side effects
Diabetes
Diabetes Mellitus, Experimental - chemically induced
Diabetes Mellitus, Experimental - pathology
Drug dosages
Glucose
Glycogen
Histopathology
Hyperglycemia
Immunohistochemistry
Insulin
Insulin - blood
Insulin resistance
Laboratory animals
Lipids
Male
Metabolism
Nigella sativa - chemistry
Oxidative Stress
Pancreas
Pharmaceuticals
Rats
Rats, Wistar
Rodents
Seeds
Streptozocin - adverse effects
Toxicology
Veterinary medicine
Egypt
Turkey
Suez Canal
United States > US
ISSN:1942-0900, 1942-0994, 1942-0994
Online Access:Get full text
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Summary:Diabetes mellitus is one of the metabolic diseases having several complications. Nigella sativa oil (NSO) might have beneficial effects in the treatment of diabetic complications. Thirty-two mature male Wistar rats were equally divided into four experimental groups: control, control NSO 2 mL/kg, streptozotocin- (STZ-) induced diabetic, and diabetic (STZ-induced) treated with oral NSO 2 mg/kg for 30 days. Fasting blood glucose (FBG), insulin, and lipid profile levels were determined. Pancreatic and hepatic tissues were used for catalase and GSH. Histopathology, hepatic glycogen contents, insulin immunohistochemistry, and pancreatic islet morphometry were performed. NSO 2 mL/kg was noticed to decrease (P<0.05) FBG and increase (P<0.05) insulin levels in diabetic rats than in diabetic nontreated animals. Lipid profile showed significant (P<0.5) improvement in diabetic rats that received NSO 2 mL/kg than in the diabetic group. Both pancreatic and hepatic catalase and GSH activities revealed a significant (P<0.05) increment in the diabetic group treated with NSO than in the diabetic animals. NSO improved the histopathological picture and hepatic glycogen contents of the diabetic group as well as increased (P<0.05) insulin immunoreactive parts % and mean pancreatic islet diameter. NSO exerts ameliorative and therapeutic effects on the STZ-induced diabetic male Wistar rats.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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Academic Editor: Lotfi Aleya
ISSN:1942-0900
1942-0994
1942-0994
DOI:10.1155/2018/8104165