The Actin Cytoskeleton and Actin-Based Motility

The actin cytoskeleton-a collection of actin filaments with their accessory and regulatory proteins-is the primary force-generating machinery in the cell. It can produce pushing (protrusive) forces through coordinated polymerization of multiple actin filaments or pulling (contractile) forces through...

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Bibliographic Details
Published in:Cold Spring Harbor perspectives in biology Vol. 10; no. 1
Main Author: Svitkina, Tatyana
Format: Journal Article
Language:English
Published: United States 01.01.2018
Subjects:
Actin Cytoskeleton - chemistry
Actin Cytoskeleton - physiology
Actins - physiology
Animals
Biological Transport
Cell Movement
Humans
Morphogenesis
Muscle Contraction
Myosin Type II - chemistry
Myosin Type II - physiology
Phagocytosis
ISSN:1943-0264, 1943-0264
Online Access:Get more information
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Summary:The actin cytoskeleton-a collection of actin filaments with their accessory and regulatory proteins-is the primary force-generating machinery in the cell. It can produce pushing (protrusive) forces through coordinated polymerization of multiple actin filaments or pulling (contractile) forces through sliding actin filaments along bipolar filaments of myosin II. Both force types are particularly important for whole-cell migration, but they also define and change the cell shape and mechanical properties of the cell surface, drive the intracellular motility and morphogenesis of membrane organelles, and allow cells to form adhesions with each other and with the extracellular matrix.
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ISSN:1943-0264
1943-0264
DOI:10.1101/cshperspect.a018267