Glucose utilization via glycogen phosphorylase sustains proliferation and prevents premature senescence in cancer cells

Metabolic reprogramming of cancer cells provides energy and multiple intermediates critical for cell growth. Hypoxia in tumors represents a hostile environment that can encourage these transformations. We report that glycogen metabolism is upregulated in tumors in vivo and in cancer cells in vitro i...

Full description

Saved in:

Bibliographic Details
Published in:	Cell metabolism Vol. 16; no. 6; p. 751
Main Authors:	Favaro, Elena, Bensaad, Karim, Chong, Mei G, Tennant, Daniel A, Ferguson, David J P, Snell, Cameron, Steers, Graham, Turley, Helen, Li, Ji-Liang, Günther, Ulrich L, Buffa, Francesca M, McIntyre, Alan, Harris, Adrian L
Format:	Journal Article
Language:	English
Published:	United States 05.12.2012
Subjects:	Angiogenesis Inhibitors - pharmacology Animals Antibodies, Monoclonal, Humanized - pharmacology Bevacizumab Breast Neoplasms - metabolism Breast Neoplasms - pathology Cell Hypoxia - drug effects Cell Line, Tumor Cell Proliferation - drug effects Cellular Senescence - drug effects Female Glucose - pharmacology Glycogen - metabolism Glycogen Phosphorylase - antagonists & inhibitors Glycogen Phosphorylase - genetics Glycogen Phosphorylase - metabolism Glycogen Synthase - metabolism HCT116 Cells Humans MCF-7 Cells Mice Mice, Nude Reactive Oxygen Species - metabolism RNA Interference RNA, Small Interfering - metabolism Transplantation, Heterologous Tumor Suppressor Protein p53 - metabolism
ISSN:	1932-7420, 1932-7420
Online Access:	Get more information
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!