Glucose utilization via glycogen phosphorylase sustains proliferation and prevents premature senescence in cancer cells

Metabolic reprogramming of cancer cells provides energy and multiple intermediates critical for cell growth. Hypoxia in tumors represents a hostile environment that can encourage these transformations. We report that glycogen metabolism is upregulated in tumors in vivo and in cancer cells in vitro i...

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Veröffentlicht in:	Cell metabolism Jg. 16; H. 6; S. 751
Hauptverfasser:	Favaro, Elena, Bensaad, Karim, Chong, Mei G, Tennant, Daniel A, Ferguson, David J P, Snell, Cameron, Steers, Graham, Turley, Helen, Li, Ji-Liang, Günther, Ulrich L, Buffa, Francesca M, McIntyre, Alan, Harris, Adrian L
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 05.12.2012
Schlagworte:	Angiogenesis Inhibitors - pharmacology Animals Antibodies, Monoclonal, Humanized - pharmacology Bevacizumab Breast Neoplasms - metabolism Breast Neoplasms - pathology Cell Hypoxia - drug effects Cell Line, Tumor Cell Proliferation - drug effects Cellular Senescence - drug effects Female Glucose - pharmacology Glycogen - metabolism Glycogen Phosphorylase - antagonists & inhibitors Glycogen Phosphorylase - genetics Glycogen Phosphorylase - metabolism Glycogen Synthase - metabolism HCT116 Cells Humans MCF-7 Cells Mice Mice, Nude Reactive Oxygen Species - metabolism RNA Interference RNA, Small Interfering - metabolism Transplantation, Heterologous Tumor Suppressor Protein p53 - metabolism
ISSN:	1932-7420, 1932-7420
Online-Zugang:	Weitere Angaben
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