Role of F-18 FDG PET/CT in assessing IgG4-related disease with inflammation of head and neck glands

Purpose The aim of the current study was to evaluate the utility of F-18-fluoro-2-deoxy- d -glucose (F-18 FDG) positron emission tomography/computed tomography (PET/CT) in assessing patients diagnosed with immunoglobulin G4 (IgG4)-related disease (IgG4-RD) with inflammation of the head and neck glan...

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Vydáno v:Annals of nuclear medicine Ročník 29; číslo 6; s. 499 - 505
Hlavní autoři: Tokue, Azusa, Higuchi, Tetsuya, Arisaka, Yukiko, Nakajima, Takahito, Tokue, Hiroyuki, Tsushima, Yoshito
Médium: Journal Article
Jazyk:angličtina
Vydáno: Tokyo Springer Japan 01.07.2015
Springer Nature B.V
Témata:
Adult
Aged
Aged, 80 and over
Autoimmune Hypophysitis - blood
Autoimmune Hypophysitis - diagnosis
Autoimmune Hypophysitis - diagnostic imaging
Female
Fluorodeoxyglucose F18
Humans
Imaging
Lacrimal Apparatus - diagnostic imaging
Male
Medicine
Medicine & Public Health
Middle Aged
Multimodal Imaging - methods
Nuclear Medicine
Original Article
Positron-Emission Tomography - methods
Radiology
Radiopharmaceuticals
Retrospective Studies
Salivary Glands - diagnostic imaging
Sialography - methods
Tomography, X-Ray Computed - methods
Immunoglobulin G4 (IgG4)-related disease
Standardized uptake value (SUV)
Salivary gland
Lacrimal gland
F-18 FDG PET/CT
ISSN:0914-7187, 1864-6433, 1864-6433
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Shrnutí:Purpose The aim of the current study was to evaluate the utility of F-18-fluoro-2-deoxy- d -glucose (F-18 FDG) positron emission tomography/computed tomography (PET/CT) in assessing patients diagnosed with immunoglobulin G4 (IgG4)-related disease (IgG4-RD) with inflammation of the head and neck glands. Methods We reviewed the records of 17 patients (16 men and 1 woman) with IgG4-RD exhibiting inflammation of the head and neck glands (lacrimal or salivary glands; LSG) who were diagnosed by excisional biopsy of the LSG. F-18 FDG PET/CT images were retrospectively evaluated for locations of high FDG accumulation, and the maximum standardized uptake value (SUV max ) of each lesion was calculated. Results In 15 of 17 patients (88 %), FDG accumulation was observed in organs outside of the biopsied LSG. High FDG accumulation was most frequently seen in the lymph node (71 %), followed by the non-biopsied LSG (41 %). FDG accumulation was also found in other typically affected organs including the prostate and retroperitoneum (18 %), kidney and lung (12 %), and pancreas (1 %). FDG accumulation was most commonly observed in two lesions outside of the biopsied site (41 %). Conclusions Detection of the multi-organ involvement before treatment is important for patients with IgG4-RD. F-18 FDG PET/CT is an effective tool for assessing the location of extra-LSG lesions in patients with IgG4-RD with LSG inflammation.
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ISSN:0914-7187
1864-6433
1864-6433
DOI:10.1007/s12149-015-0969-3