Once Overlooked, Now Made Visible: ATL Proteins and DNA Repair

Damage report: Alkyltransferase‐like proteins (ATLs) flip DNA lesions out of the DNA duplex but have no catalytic function. They act as recognition proteins that mark DNA lesions and allow repair (see picture; NER=nucleotide excision repair).

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Bibliographische Detailangaben
Veröffentlicht in:Angewandte Chemie (International ed.) Jg. 48; H. 40; S. 7293 - 7295
Hauptverfasser: Reißner, Thomas, Schorr, Stephanie, Carell, Thomas
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Weinheim Wiley-VCH Verlag 21.09.2009
WILEY-VCH Verlag
WILEY‐VCH Verlag
Schlagworte:
Alkyl and Aryl Transferases - chemistry
Alkyl and Aryl Transferases - metabolism
Alkylating Agents - chemistry
Alkylation
DNA lesions
DNA Repair
Escherichia coli Proteins - chemistry
Escherichia coli Proteins - metabolism
molecular recognition
nucleotides
O-Methylguanine-DNA Methyltransferase - chemistry
O-Methylguanine-DNA Methyltransferase - metabolism
ISSN:1433-7851, 1521-3773, 1521-3773
Online-Zugang:Volltext
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Zusammenfassung:Damage report: Alkyltransferase‐like proteins (ATLs) flip DNA lesions out of the DNA duplex but have no catalytic function. They act as recognition proteins that mark DNA lesions and allow repair (see picture; NER=nucleotide excision repair).
Bibliographie:http://dx.doi.org/10.1002/anie.200904042
We thank the excellence cluster CiPSM and the DFG (SFBs 749 and 646) for financial support. T.R. is greatful to the Boehringer Ingelheim Foundations for a predoctoral fellowship.
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ark:/67375/WNG-DQ97P700-X
ArticleID:ANIE200904042
DFG
We thank the excellence cluster CiPS
M
and the DFG (SFBs 749 and 646) for financial support. T.R. is greatful to the Boehringer Ingelheim Foundations for a predoctoral fellowship.
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ISSN:1433-7851
1521-3773
1521-3773
DOI:10.1002/anie.200904042