Predicting cardiac electrical response to sodium-channel blockade and Brugada syndrome using polygenic risk scores

Abstract Aims Sodium-channel blockers (SCBs) are associated with arrhythmia, but variability of cardiac electrical response remains unexplained. We sought to identify predictors of ajmaline-induced PR and QRS changes and Type I Brugada syndrome (BrS) electrocardiogram (ECG). Methods and results In 1...

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Bibliographic Details

Published in:	European heart journal Vol. 40; no. 37; pp. 3097 - 3107
Main Authors:	Tadros, Rafik, Tan, Hanno L, el Mathari, Sulayman, Kors, Jan A, Postema, Pieter G, Lahrouchi, Najim, Beekman, Leander, Radivojkov-Blagojevic, Milena, Amin, Ahmad S, Meitinger, Thomas, Tanck, Michael W, Wilde, Arthur A, Bezzina, Connie R
Format:	Journal Article
Language:	English
Published:	England Oxford University Press 01.10.2019
Subjects:	Polygenic risk score PR QRS Ajmaline Brugada syndrome
ISSN:	0195-668X, 1522-9645, 1522-9645
Online Access:	Get full text
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