Basal ganglia, thalamus and neocortical atrophy predicting slowed cognitive processing in multiple sclerosis

Information-processing speed (IPS) slowing is a primary cognitive deficit in multiple sclerosis (MS). Basal ganglia, thalamus and neocortex are thought to have a key role for efficient information-processing, yet the specific relative contribution of these structures for MS-related IPS impairment is...

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Veröffentlicht in:Journal of neurology Jg. 259; H. 1; S. 139 - 146
Hauptverfasser: Batista, Sonia, Zivadinov, Robert, Hoogs, Marietta, Bergsland, Niels, Heininen-Brown, Mari, Dwyer, Michael G., Weinstock-Guttman, Bianca, Benedict, Ralph H. B.
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Berlin/Heidelberg Springer-Verlag 01.01.2012
Springer
Springer Nature B.V
Schlagworte:
Adult
Atrophy
Basal ganglia
Basal Ganglia - pathology
Biological and medical sciences
Brain
Cognition Disorders - etiology
Cognition Disorders - psychology
Cognitive ability
Computer programs
Cortex
Data Interpretation, Statistical
Female
Globus pallidus
Humans
Image Processing, Computer-Assisted
Information processing
Magnetic Resonance Imaging
Male
Measuring techniques
Medical sciences
Medicine
Medicine & Public Health
Middle Aged
Multiple sclerosis
Multiple Sclerosis - complications
Multiple Sclerosis - pathology
Multiple Sclerosis - psychology
Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis
Neocortex - pathology
Neurology
Neuropsychological Tests
Neuropsychology
Neuroradiology
Neurosciences
Nucleus accumbens
Original Communication
Predictive Value of Tests
Psychology
Putamen
Sensory integration
software
Substantia grisea
Thalamus
Thalamus - pathology
Volumetric analysis
Thalamus
Multiple sclerosis
Basal ganglia
Magnetic resonance imaging
Neocortex
Cognitive dysfunction
Nervous system diseases
Cognitive disorder
Central nervous system
Basal ganglion
Nuclear magnetic resonance imaging
Encephalon
Inflammatory disease
Atrophy
Central nervous system disease
ISSN:0340-5354, 1432-1459, 1432-1459
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Zusammenfassung:Information-processing speed (IPS) slowing is a primary cognitive deficit in multiple sclerosis (MS). Basal ganglia, thalamus and neocortex are thought to have a key role for efficient information-processing, yet the specific relative contribution of these structures for MS-related IPS impairment is poorly understood. To determine if basal ganglia and thalamus atrophy independently contribute to visual and auditory IPS impairment in MS, after controlling for the influence of neocortical volume, we enrolled 86 consecutive MS patients and 25 normal controls undergoing 3T brain MRI and neuropsychological testing. Using Sienax and FIRST software, neocortical and deep gray matter (DGM) volumes were calculated. Neuropsychological testing contributed measures of auditory and visual IPS using the Paced Auditory Serial Addition Test (PASAT) and the Symbol Digit Modalities Test (SDMT), respectively. MS patients exhibited significantly slower IPS relative to controls and showed reduction in neocortex, caudate, putamen, globus pallidus, thalamus and nucleus accumbens volume. SDMT and PASAT were significantly correlated with all DGM regions. These effects were mitigated by controlling for the effects of neocortical volume, but all DGM volumes remained significantly correlated with SDMT, putamen ( r  = 0.409, p  < 0.001) and thalamus ( r  = 0.362, p  < 0.001) having the strongest effects, whereas for PASAT, the correlation was significant for putamen ( r  = 0.313, p  < 0.01) but not for thalamus. We confirm the significant role of thalamus atrophy in MS-related IPS slowing and find that putamen atrophy is also a significant contributor to this disorder. These DGM structures have independent, significant roles, after controlling for the influence of neocortex atrophy.
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ISSN:0340-5354
1432-1459
1432-1459
DOI:10.1007/s00415-011-6147-1