Environmental cues regulate epigenetic reprogramming of airway-resident memory CD8+ T cells

Tissue-resident memory T cells (T RM cells) are critical for cellular immunity to respiratory pathogens and reside in both the airways and the interstitium. In the present study, we found that the airway environment drove transcriptional and epigenetic changes that specifically regulated the cytolyt...

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Veröffentlicht in:	Nature immunology Jg. 21; H. 3; S. 309 - 320
Hauptverfasser:	Hayward, Sarah L., Scharer, Christopher D., Cartwright, Emily K., Takamura, Shiki, Li, Zheng-Rong Tiger, Boss, Jeremy M., Kohlmeier, Jacob E.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	New York Nature Publishing Group US 01.03.2020 Nature Publishing Group
Schlagworte:	631/250/2152/1566/1571 631/250/347 Amino acid starvation Amino acids Animals Apoptosis Apoptosis - immunology Biomedical and Life Sciences Biomedicine CD8 antigen CD8-Positive T-Lymphocytes - cytology CD8-Positive T-Lymphocytes - immunology Cell activation Cell death Cell lineage Cell Survival - genetics Cell Survival - immunology Cell-mediated immunity Cellular Microenvironment - genetics Cellular Microenvironment - immunology Cellular Reprogramming - genetics Cellular Reprogramming - immunology Cellular stress response Effector cells Epigenesis, Genetic - immunology Epigenetics Female Immunologic Memory - genetics Immunological memory Immunology Infectious Diseases Lung - cytology Lung - immunology Lymphocytes Lymphocytes T Male Memory cells Mice Mice, Inbred C57BL Orthomyxoviridae Infections - genetics Orthomyxoviridae Infections - immunology Orthomyxoviridae Infections - pathology Respiratory diseases Respiratory tract Spleen Stress response Transcription
ISSN:	1529-2908, 1529-2916, 1529-2916
Online-Zugang:	Volltext
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