Functional disintegration in paranoid schizophrenia using resting-state fMRI

Functional disintegration has been observed in schizophrenia during task performance. We sought to investigate functional disintegration during rest because an intrinsic functional brain organization, including both “task-negative” (i.e., “default mode”) and “task-positive” networks, has been sugges...

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Bibliographic Details
Published in:	Schizophrenia research Vol. 97; no. 1; pp. 194 - 205
Main Authors:	Zhou, Yuan, Liang, Meng, Tian, Lixia, Wang, Kun, Hao, Yihui, Liu, Haihong, Liu, Zhening, Jiang, Tianzi
Format:	Journal Article
Language:	English
Published:	Amsterdam Elsevier B.V 01.12.2007 Elsevier Science
Subjects:	Adolescent Adult Adult and adolescent clinical studies Biological and medical sciences Cerebral Cortex - physiopathology Dominance, Cerebral - physiology Female fMRI Functional connectivity Gyrus Cinguli - physiopathology Humans Image Processing, Computer-Assisted Magnetic Resonance Imaging Male Medical sciences Motor Cortex - physiopathology Nerve Net - physiopathology Parietal Lobe - physiopathology Prefrontal Cortex - physiopathology Psychiatric/Mental Health Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychoses Reference Values Rest - physiology Resting-state Schizophrenia Schizophrenia, Paranoid - diagnosis Schizophrenia, Paranoid - physiopathology Schizophrenia, Paranoid - psychology Temporal Lobe - physiopathology Functional connectivity IPL LP Schizophrenia MNI IFG L PHG SMA/pre-SMA Ins MFG OFG R BOLD dPM dMPFC PCu DLPFC MT Resting-state PCC PostCG fMRI ITG CPL cerebellar posterior lobe supplementary motor area/pre-supplementary motor area postcentral gyrus insula dorsolateral prefrontal cortex orbital frontal gyrus blood oxygen level-dependent lateral parietal region inferior frontal gyrus right middle temporal region Montreal Neurological Institute dorsal medial prefrontal cortex left middle frontal gyrus precuneus inferior parietal lobule inferior temporal gyrus parahippocampus gyrus posterior cingulated cortex dorsal premotor cortex Psychosis Human Rest Paranoid schizophrenia Medical imagery Nuclear magnetic resonance imaging Functional imaging
ISSN:	0920-9964, 1573-2509
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Summary:	Functional disintegration has been observed in schizophrenia during task performance. We sought to investigate functional disintegration during rest because an intrinsic functional brain organization, including both “task-negative” (i.e., “default mode”) and “task-positive” networks, has been suggested to play an important role in integrating ongoing information processing. Additionally, the brain regions that are involved in the intrinsic organization are believed to be abnormal in schizophrenia. Patients with paranoid schizophrenia ( N = 18) and healthy volunteers ( N = 18) underwent a resting-state fMRI scan. Functional connectivity analysis was used to identify the connectivity between each pair of brain regions within this intrinsic organization, and differences were examined in patients versus healthy volunteers. Compared to healthy volunteers, patients showed significant differences in connectivity within networks and between networks, most notably in the connectivities associated with the bilateral dorsal medial prefrontal cortex, the lateral parietal region, the inferior temporal gyrus of the “task-negative” network and with the right dorsolateral prefrontal cortex and the right dorsal premotor cortex of the “task-positive” network. These results suggested that the interregional functional connectivities in the intrinsic organization are altered in patients with paranoid schizophrenia. These abnormalities could be the source of abnormalities in the coordination of and competition between information processing activities in the resting brain of paranoid patients.
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ISSN:	0920-9964 1573-2509
DOI:	10.1016/j.schres.2007.05.029