Role of RNA modifications in cancer

Specific chemical modifications of biological molecules are an efficient way of regulating molecular function, and a plethora of downstream signalling pathways are influenced by the modification of DNA and proteins. Many of the enzymes responsible for regulating protein and DNA modifications are tar...

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Vydáno v:	Nature reviews. Cancer Ročník 20; číslo 6; s. 303 - 322
Hlavní autoři:	Barbieri, Isaia, Kouzarides, Tony
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	England Nature Publishing Group 01.06.2020
Témata:	Cancer Cancer therapies Deoxyribonucleic acid DNA Epigenesis, Genetic - genetics Epigenesis, Genetic - physiology Humans Molecular Targeted Therapy mRNA Neoplasms - drug therapy Neoplasms - genetics Neoplasms - metabolism Non-coding RNA RNA - genetics RNA - metabolism RNA modification RNA Processing, Post-Transcriptional - genetics RNA Processing, Post-Transcriptional - physiology RNA, Messenger - genetics RNA, Messenger - metabolism rRNA Signal transduction Transcription Transfer RNA
ISSN:	1474-175X, 1474-1768, 1474-1768
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Shrnutí:	Specific chemical modifications of biological molecules are an efficient way of regulating molecular function, and a plethora of downstream signalling pathways are influenced by the modification of DNA and proteins. Many of the enzymes responsible for regulating protein and DNA modifications are targets of current cancer therapies. RNA epitranscriptomics, the study of RNA modifications, is the new frontier of this arena. Despite being known since the 1970s, eukaryotic RNA modifications were mostly identified on transfer RNA and ribosomal RNA until the last decade, when they have been identified and characterized on mRNA and various non-coding RNAs. Increasing evidence suggests that RNA modification pathways are also misregulated in human cancers and may be ideal targets of cancer therapy. In this Review we highlight the RNA epitranscriptomic pathways implicated in cancer, describing their biological functions and their connections to the disease.
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Review-3 content type line 23
ISSN:	1474-175X 1474-1768 1474-1768
DOI:	10.1038/s41568-020-0253-2