Angiopoietin-2 may contribute to multiple organ dysfunction and death in sepsis

: In sepsis, quiescent blood vessels become leaky and inflamed by mechanisms that are incompletely understood. We hypothesized that angiopoietin-2, a partial antagonist of the endothelium-stabilizing receptor Tie-2 secreted by endothelium, contributes to adverse outcomes in this disease. : Laborator...

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Vydané v:	Critical care medicine Ročník 40; číslo 11; s. 3034
Hlavní autori:	David, Sascha, Mukherjee, Aditi, Ghosh, Chandra C, Yano, Midori, Khankin, Eliyahu V, Wenger, Julia B, Karumanchi, S Ananth, Shapiro, Nathan I, Parikh, Samir M
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 01.11.2012
Predmet:	Adult Aged Aged, 80 and over Angiopoietin-2 - genetics Angiopoietin-2 - immunology Angiopoietin-2 - physiology Animals Female Heterozygote Humans Male Mice Mice, 129 Strain Mice, Inbred C57BL Middle Aged Multiple Organ Failure - mortality Multiple Organ Failure - physiopathology Sepsis - mortality Sepsis - physiopathology Survival Analysis
ISSN:	1530-0293, 1530-0293
On-line prístup:	Zistit podrobnosti o prístupe
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