Gout and risk of dementia, Alzheimer's disease or vascular dementia: a meta-epidemiology study

The association between gout and dementia, Alzheimer's disease (AD), or vascular dementia (VD) is not fully understood. The aim of this meta-analysis was to evaluate the risk of all-cause dementia, AD, and VD in gout patients with or without medication. Data sources were PubMed, Embase, the Coc...

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Veröffentlicht in:Frontiers in aging neuroscience Jg. 15; S. 1051809
Hauptverfasser: Li, Xuanlin, Huang, Lin, Tang, Yujun, Hu, Xuanming, Wen, Chengping
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Switzerland Frontiers Research Foundation 26.04.2023
Frontiers Media S.A
Schlagworte:
Aging Neuroscience
Alzheimer's disease
Citation management software
Cohort analysis
Dementia
Dementia disorders
Epidemiology
Gout
Meta-analysis
Neurodegenerative diseases
Older people
Quality control
Rheumatism
Sensitivity analysis
Sexually transmitted diseases
STD
Uric acid
Vascular dementia
United States > US
China
meta-analysis
dementia
Alzheimer's disease
vascular dementia
gout
ISSN:1663-4365, 1663-4365
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Zusammenfassung:The association between gout and dementia, Alzheimer's disease (AD), or vascular dementia (VD) is not fully understood. The aim of this meta-analysis was to evaluate the risk of all-cause dementia, AD, and VD in gout patients with or without medication. Data sources were PubMed, Embase, the Cochrane Library, and reference lists of included studies. This meta-analysis included cohort studies assessing whether the risk of all-cause dementia, AD, and VD was associated with gout. The risk of bias was assessed using the Newcastle-Ottawa Quality Assessment Scale (NOS). The Grading of Recommendations Assessment, Development, and Evaluation (GRADE) system was used to access the overall certainty of evidence. Risk ratios ( ) with 95% confidence intervals ( ) were pooled using a random-effects model, and publication bias was assessed with funnel plots and Egger's test. A total of six cohort studies involving 2,349,605 individuals were included in this meta-analysis, which were published between 2015 and 2022. The pooling analysis shows that the risk of all-cause dementia was decreased in gout patients [ = 0.67, 95% (0.51, 0.89), = 99%, = 0.005, very low quality], especially in gout patients with medication [ = 0.50, 95% (0.31, 0.79), = 93%, = 0.003, low quality]. The risk of AD [ = 0.70, 95% (0.63, 0.79), = 57.2%, = 0.000, very low quality] and VD [ = 0.68, 95% (0.49, 0.95), = 91.2%, = 0.025, very low quality] was also decreased in gout patients. Despite the large heterogeneity, the sensitivity analysis indicated that the results were robust, and there was little evidence of publication bias. The risk of all-cause dementia, AD, and VD is decreased in gout patients, but the quality of evidence is generally low. More studies are still needed to validate and explore the mechanisms of this association. https://www.crd.york.ac.uk/prospero/#recordDetails, identifier: CRD42022353312.
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Edited by: Keren Nitzan, Open University of Israel, Israel
Reviewed by: Francisca Sivera, Hospital General de Elda, Spain; Xinwei Wu, National Institutes of Health (NIH), United States
This article was submitted to Alzheimer's Disease and Related Dementias, a section of the journal Frontiers in Aging Neuroscience
ISSN:1663-4365
1663-4365
DOI:10.3389/fnagi.2023.1051809