Stress-triggered hematopoietic stem cell proliferation relies on PrimPol-mediated repriming

Stem cell division is linked to tumorigenesis by yet-elusive mechanisms. The hematopoietic system reacts to stress by triggering hematopoietic stem and progenitor cell (HSPC) proliferation, which can be accompanied by chromosomal breakage in activated hematopoietic stem cells (HSCs). However, whethe...

Full description

Saved in:

Bibliographic Details
Published in:	Molecular cell Vol. 82; no. 21; p. 4176
Main Authors:	Jacobs, Kurt, Doerdelmann, Cyril, Krietsch, Jana, González-Acosta, Daniel, Mathis, Nicolas, Kushinsky, Saul, Guarino, Estrella, Gómez-Escolar, Carmen, Martinez, Dolores, Schmid, Jonas A, Leary, Peter J, Freire, Raimundo, Ramiro, Almudena R, Eischen, Christine M, Mendez, Juan, Lopes, Massimo
Format:	Journal Article
Language:	English
Published:	United States 03.11.2022
Subjects:	Animals Cell Proliferation DNA Damage DNA Replication Hematopoiesis - genetics Hematopoietic Stem Cells - physiology Mice DNA replication Primpol stem cell division repriming DNA damage response bone marrow reconstitution hematopoietic stem cells replication fork plasticity induced proliferation
ISSN:	1097-4164, 1097-4164
Online Access:	Get more information
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!