Dynamic alterations of spontaneous neural activity in post-stroke aphasia: a resting-state functional magnetic resonance imaging study

The dynamic alterations in spontaneous neural activity of the brain during the acute phase of post-stroke aphasia (PSA) remain unclear. Therefore, in this study, dynamic amplitude of low-frequency fluctuation (dALFF) was applied to explore abnormal temporal variability in local functional activity o...

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Published in:Frontiers in neuroscience Vol. 17; p. 1177930
Main Authors: Xu, Luyao, Wei, Hongchun, Sun, Zhongwen, Chu, Tongpeng, Li, Min, Liu, Ruhui, Jiang, Li, Liang, Zhigang
Format: Journal Article
Language:English
Published: Switzerland Frontiers Research Foundation 11.05.2023
Frontiers Media S.A
Subjects:
Aphasia
Brain
Brain mapping
brain networks
Cerebellum
clustering
dynamic amplitude of low-frequency fluctuation
Education
Fourier transforms
Functional magnetic resonance imaging
Language
Magnetic resonance imaging
Mental disorders
Methods
Neuroimaging
Neuroscience
post-stroke aphasia
Recovery of function
resting-state functional magnetic resonance imaging
Stroke
resting-state functional magnetic resonance imaging
dynamic amplitude of low-frequency fluctuation
clustering
brain networks
post-stroke aphasia
ISSN:1662-453X, 1662-4548, 1662-453X
Online Access:Get full text
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Summary:The dynamic alterations in spontaneous neural activity of the brain during the acute phase of post-stroke aphasia (PSA) remain unclear. Therefore, in this study, dynamic amplitude of low-frequency fluctuation (dALFF) was applied to explore abnormal temporal variability in local functional activity of the brain during acute PSA. Resting-state functional magnetic resonance imaging (rs-fMRI) data from 26 patients with PSA and 25 healthy controls (HCs) were acquired. The sliding window method was used to assess dALFF, with the k-means clustering method used to identify dALFF states. The two-sample -test was applied to compare differences in dALFF variability and state metrics between the PSA and HC groups. (1) In the PSA group, greater variance of dALFF in the cerebellar network (CBN) and left fronto-temporo-parietal network (FTPN) was observed. (2) Three dALFF states were identified among all subjects. States 1 and 2 were identified in the PSA patients, and the two dALFF states shared a similar proportion. Moreover, the number of transitions between the two dALFF states was higher in the patients compared with that in HCs. The results of this study provide valuable insights into brain dysfunction that occurs during the acute phase (6.00 ± 3.52 days) of PSA. The observed increase in variability of local functional activities in CBN and left FTPN may be related to the spontaneous functional recovery of language during acute PSA, and it also suggests that cerebellum plays an important role in language.
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These authors have contributed equally to this work
Reviewed by: Catalina Elena Bistriceanu, Grigore T. Popa University of Medicine and Pharmacy, Romania; Zhu Zhengyu, The Second Hospital of Shandong University, China
Edited by: Seong Dae Yun, Helmholtz Association of German Research Centres (HZ), Germany
ISSN:1662-453X
1662-4548
1662-453X
DOI:10.3389/fnins.2023.1177930