Prevalence and Associated Factors of Pseudoexfoliation in a Russian Population: The Ural Eye and Medical Study

To assess the prevalence of pseudoexfoliation (PEX) and its associations in a Russian population. Population-based cross-sectional study. Setting: Ufa capital of Bashkortostan, Russia and a rural region in Bashkortostan. the Ural Eye and Medical Study included 5,899 (80.5%) of 7,328 eligible individ...

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Veröffentlicht in:American journal of ophthalmology Jg. 210; S. 158 - 166
Hauptverfasser: Bikbov, Mukharram M., Zainullin, Rinat M., Gilmanshin, Timur R., Kazakbaeva, Gyulli M., Yakupova, Dilya F., Nuriev, Ildar F., Zaynetdinov, Artur F., Khalimov, Timur A., Panda-Jonas, Songhomitra, Uzianbaeva, Yulia V., Rakhimova, Ellina M., Rusakova, Iulia A., Salavatova, Venera F., Arslangareeva, Inga I., Bikbova, Guzel M., Nikitin, Nikolay A., Jonas, Jost B.
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States Elsevier Inc 01.02.2020
Elsevier Limited
Schlagworte:
Adult
Age
Age Distribution
Aged
Aged, 80 and over
Blood pressure
Cataracts
Cross-Sectional Studies
Diabetes
Ethnicity
Exfoliation Syndrome - epidemiology
Exfoliation Syndrome - etiology
Eye surgery
Female
Glaucoma
Humans
Male
Middle Aged
Prevalence
Risk Factors
Rural Population - statistics & numerical data
Russia - epidemiology
Secondary education
Urban Population - statistics & numerical data
Russia
ISSN:0002-9394, 1879-1891, 1879-1891
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Zusammenfassung:To assess the prevalence of pseudoexfoliation (PEX) and its associations in a Russian population. Population-based cross-sectional study. Setting: Ufa capital of Bashkortostan, Russia and a rural region in Bashkortostan. the Ural Eye and Medical Study included 5,899 (80.5%) of 7,328 eligible individuals (mean age, 59.0 ± 10.7 years old; range, 40-94 years). Observation procedures: as part of an ophthalmological and general examination, presence and degree of PEX was assessed using slit-lamp biomicroscopy after medical pupillary dilation. Main outcome measurements: PEX prevalence. After excluding pseudophakic and aphakic individuals, the study included 5,451 (92.4%) participants. PEX prevalence (3.6%; 95% confidence interval [CI]:3.1-4.1), increased from 0.5% (95% CI, 0.1-0.9) in individuals 40 to <50 years old to 10.4% (95% CI, 5.0-15.8) in individuals aged 80+ years. Higher PEX prevalence was associated (multivariate analysis) with older age (odds ratio [OR], 1.09; 95% CI, 1.07-1.11; P < 0.001), Russian ethnicity (OR, 1.50; 95% CI, 2.09-1.11;P = 0.02), higher prevalence of open-angle glaucoma (OR, 2.40; 95% CI, 1.36-4.23;P = 0.003), and higher intraocular pressure (OR, 1.06; 95% CI, 1.02-1.09;P = 0.001). PEX prevalence was not significantly associated with gender (P = 0.49), region of habitation (P = 0.11), body mass index (P = 0.68), level of education (P = 0.26), smoking (P = 0.11), alcohol consumption (P = 0.52), history of cardiovascular or cerebrovascular disease (P = 0.94) and dementia (P = 0.77), prevalence of diabetes mellitus (P = 0.16), arterial hypertension (P = 0.45), chronic obstructive pulmonary disease (P = 0.73), chronic kidney disease (P = 0.09), and hearing loss (P = 0.31). In this typical, ethnically mixed, population from Russia with an age of 40+ years, PEX prevalence (3.6%; 95% CI, 3.1-4.1) was associated with older age, Russian ethnicity, higher intraocular pressure and open-angle glaucoma. It was independent of any systemic parameter including diabetes, arterial hypertension, previous cardiovascular and cerebrovascular diseases and dementia.
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ISSN:0002-9394
1879-1891
1879-1891
DOI:10.1016/j.ajo.2019.10.003