A comprehensive immunohistochemical and molecular approach to the PI3K/AKT/mTOR (phosphoinositide 3‐kinase/v‐akt murine thymoma viral oncogene/mammalian target of rapamycin) pathway in bladder urothelial carcinoma

What's known on the subject? and What does the study add? A few published studies investigating single or various PI3K/AKT/mTOR signalling components have produced inconsistent results. Moreover, PI3K regulatory subunit p85a and activated p70S6K expression levels have not been previously examin...

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Veröffentlicht in:	BJU international Jg. 110; H. 11c; S. E1237 - E1248
Hauptverfasser:	Korkolopoulou, Penelope, Levidou, Georgia, Trigka, Eleni‐Andriana, Prekete, Niki, Karlou, Maria, Thymara, Irene, Sakellariou, Stratigoula, Fragkou, Paraskevi, Isaiadis, Dimitrios, Pavlopoulos, Petros, Patsouris, Efstratios, Saetta, Angelica A.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Oxford, UK Blackwell Publishing Ltd 01.12.2012 Wiley Subscription Services, Inc
Schlagworte:	1-Phosphatidylinositol 3-kinase 4E‐BP1 Adult Aged Aged, 80 and over AKT AKT protein AKT1 AKT1 protein bladder cancer Carcinoma, Transitional Cell - genetics Carcinoma, Transitional Cell - metabolism Carcinoma, Transitional Cell - pathology Chemotherapy Class I Phosphatidylinositol 3-Kinases DNA, Neoplasm - genetics Extracellular signal-regulated kinase Female Fibroblast growth factor receptor 3 Fibroblast growth factor receptors Follow-Up Studies Humans Immunohistochemistry Initiation factors Kinases Male Middle Aged mTOR Mutation Oncogenes p70S6K p85aPI3K Phosphatidylinositol 3-Kinases - genetics Phosphatidylinositol 3-Kinases - metabolism phosphoinositides PIK3CA Polymerase Chain Reaction Prognosis Proto-Oncogene Proteins c-akt - genetics Proto-Oncogene Proteins c-akt - metabolism Regulatory subunits Retrospective Studies Signal Transduction Studies Survival Survival analysis thymoma TOR protein TOR Serine-Threonine Kinases - genetics TOR Serine-Threonine Kinases - metabolism Tumorigenesis UCS Urinary bladder Urinary Bladder Neoplasms - genetics Urinary Bladder Neoplasms - metabolism Urinary Bladder Neoplasms - pathology urothelial carcinoma urothelium
ISSN:	1464-4096, 1464-410X, 1464-410X
Online-Zugang:	Volltext
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