Targeted DNA methylation profiling reveals epigenetic signatures in peanut allergy

DNA methylation (DNAm) has been shown to play a role in mediating food allergy; however, the mechanism by which it does so is poorly understood. In this study, we used targeted next-generation bisulfite sequencing to evaluate DNAm levels in 125 targeted highly informative genomic regions containing...

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Veröffentlicht in:	JCI insight Jg. 6; H. 6
Hauptverfasser:	Zhou, Xiaoying, Han, Xiaorui, Lyu, Shu-Chen, Bunning, Bryan, Kost, Laurie, Chang, Iris, Cao, Shu, Sampath, Vanitha, Nadeau, Kari C.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States American Society for Clinical Investigation 22.03.2021 American Society for Clinical investigation
Schlagworte:	Allergens Bisulfite Brain-derived neurotrophic factor CpG Islands Cytokines Cytokines - immunology DNA fingerprinting DNA Methylation Epigenesis, Genetic Epigenetics Food allergies Gene Expression Profiling Genes Genetic factors Genetics Humans Immunology Innate immunity Kinases Lymphocytes T Mann-Whitney U test Peanut Hypersensitivity - genetics Peripheral blood Proteins Siblings Th2 Cells - immunology Twins Epigenetics Allergy Genetics Immunology
ISSN:	2379-3708, 2379-3708
Online-Zugang:	Volltext
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