Semaglutide lowers body weight in rodents via distributed neural pathways

Semaglutide, a glucagon-like peptide 1 (GLP-1) analog, induces weight loss, lowers glucose levels, and reduces cardiovascular risk in patients with diabetes. Mechanistic preclinical studies suggest weight loss is mediated through GLP-1 receptors (GLP-1Rs) in the brain. The findings presented here sh...

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Bibliographic Details
Published in:	JCI insight Vol. 5; no. 6
Main Authors:	Gabery, Sanaz, Salinas, Casper G., Paulsen, Sarah J., Ahnfelt-Rønne, Jonas, Alanentalo, Tomas, Baquero, Arian F., Buckley, Stephen T., Farkas, Erzsébet, Fekete, Csaba, Frederiksen, Klaus S., Helms, Hans Christian C., Jeppesen, Jacob F., John, Linu M., Pyke, Charles, Nøhr, Jane, Lu, Tess T., Polex-Wolf, Joseph, Prevot, Vincent, Raun, Kirsten, Simonsen, Lotte, Sun, Gao, Szilvásy-Szabó, Anett, Willenbrock, Hanni, Secher, Anna, Knudsen, Lotte Bjerre
Format:	Journal Article
Language:	English
Published:	United States American Society for Clinical Investigation 26.03.2020
Subjects:	Ablation Animals Area postrema Blood-brain barrier Body Weight - drug effects Brain Brain - drug effects Brain stem c-Fos protein Cardiovascular diseases Clinical trials Diabetes Diabetes mellitus Eating - drug effects Energy expenditure Energy intake Energy Metabolism - drug effects Food Food intake Food preferences Glucagon Glucagon-like peptide 1 Glucagon-Like Peptide-1 Receptor - drug effects Glucagon-Like Peptides - pharmacology Hindbrain Homeostasis Hypothalamus Mice Neural networks Neural Pathways - drug effects Obesity Parabrachial nucleus Peptides Prolactin Rats Regulatory approval Reinforcement Thyrotropin-releasing hormone Transcriptomics Tyrosine 3-monooxygenase Ventricles (cerebral) Weight Weight control Neuroimaging Obesity Neuroscience Metabolism Mouse models
ISSN:	2379-3708, 2379-3708
Online Access:	Get full text
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