R-Loops as Cellular Regulators and Genomic Threats

During transcription, the nascent RNA strand can base pair with its template DNA, displacing the non-template strand as ssDNA and forming a structure called an R-loop. R-loops are common across many domains of life and cause DNA damage in certain contexts. In this review, we summarize recent results...

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Vydané v:	Molecular cell Ročník 73; číslo 3; s. 398
Hlavní autori:	Crossley, Madzia P, Bocek, Michael, Cimprich, Karlene A
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 07.02.2019
Predmet:	Animals Cell Nucleus - physiology DNA - chemistry DNA - genetics DNA - metabolism DNA Damage DNA Repair Gene Expression Regulation Genome Genomic Instability Humans Nucleic Acid Conformation Nucleic Acid Heteroduplexes - chemistry Nucleic Acid Heteroduplexes - genetics Nucleic Acid Heteroduplexes - metabolism RNA - chemistry RNA - genetics RNA - metabolism Structure-Activity Relationship Transcription, Genetic
ISSN:	1097-4164, 1097-4164
On-line prístup:	Zistit podrobnosti o prístupe
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