Error-free DNA damage tolerance and sister chromatid proximity during DNA replication rely on the Polα/Primase/Ctf4 Complex

Chromosomal replication is entwined with DNA damage tolerance (DDT) and chromatin structure establishment via elusive mechanisms. Here we examined how specific replication conditions affecting replisome architecture and repriming impact on DDT. We show that Saccharomyces cerevisiae Polα/Primase/Ctf4...

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Vydáno v:	Molecular cell Ročník 57; číslo 5; s. 812
Hlavní autoři:	Fumasoni, Marco, Zwicky, Katharina, Vanoli, Fabio, Lopes, Massimo, Branzei, Dana
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 05.03.2015
Témata:	Chromatids - genetics DNA Damage DNA Polymerase I - genetics DNA Polymerase I - metabolism DNA Primase - genetics DNA Primase - metabolism DNA Repair - genetics DNA Replication - genetics DNA, Single-Stranded - genetics DNA, Single-Stranded - metabolism DNA, Single-Stranded - ultrastructure DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism G2 Phase Cell Cycle Checkpoints - genetics Microscopy, Electron Models, Genetic Multiprotein Complexes - genetics Multiprotein Complexes - metabolism Mutation Recombination, Genetic Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae Proteins - genetics Saccharomyces cerevisiae Proteins - metabolism Signal Transduction - genetics Time Factors
ISSN:	1097-4164, 1097-4164
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