Urinary Glycosaminoglycans Predict Outcomes in Septic Shock and Acute Respiratory Distress Syndrome

Degradation of the endothelial glycocalyx, a glycosaminoglycan (GAG)-rich layer lining the vascular lumen, is associated with the onset of kidney injury in animal models of critical illness. It is unclear if similar pathogenic degradation occurs in critically ill patients. To determine if urinary in...

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Vydané v:	American journal of respiratory and critical care medicine Ročník 194; číslo 4; s. 439 - 449
Hlavní autori:	Schmidt, Eric P., Overdier, Katherine H., Sun, Xiaojun, Lin, Lei, Liu, Xinyue, Yang, Yimu, Ammons, Lee Anne, Hiller, Terra D., Suflita, Matt A., Yu, Yanlei, Chen, Yin, Zhang, Fuming, Cothren Burlew, Clay, Edelstein, Charles L., Douglas, Ivor S., Linhardt, Robert J.
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States American Thoracic Society 15.08.2016
Predmet:	Acute Kidney Injury - diagnosis Acute Kidney Injury - etiology Acute Kidney Injury - mortality Acute Kidney Injury - urine Biomarkers - urine Case-Control Studies Colorado Glycosaminoglycans - urine Hospital Mortality Humans Intensive Care Units - statistics & numerical data Mass Spectrometry - methods Original Predictive Value of Tests Prognosis Prospective Studies Shock, Septic - complications Shock, Septic - diagnosis Shock, Septic - mortality Shock, Septic - urine Trauma Severity Indices Wounds and Injuries - classification Wounds and Injuries - surgery Wounds and Injuries - urine glycocalyx heparan sulfate glycomics chondroitin sulfate hyaluronic acid
ISSN:	1073-449X, 1535-4970, 1535-4970
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