Heterochronic parabiosis for the study of the effects of aging on stem cells and their niches

Aging is unmistakable and undeniable in mammals. Interestingly, mice develop cataracts, muscle atrophy, osteoporosis, obesity, diabetes and cognitive deficits after just 2-3 postnatal years, while it takes seven or more decades for the same age-specific phenotypes to develop in humans. Thus, chronol...

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Bibliographic Details
Published in:	Cell cycle (Georgetown, Tex.) Vol. 11; no. 12; pp. 2260 - 2267
Main Authors:	Conboy, Irina M., Rando, Thomas A.
Format:	Journal Article
Language:	English
Published:	United States Taylor & Francis 15.06.2012 Landes Bioscience
Subjects:	aging Animals Binding Biology Bioscience Calcium Cancer Cell Cellular Senescence Cycle Humans Landes muscle Muscle, Skeletal - cytology Muscle, Skeletal - metabolism niche Organogenesis Parabiosis Proteins Regeneration Rejuvenation Signal Transduction Stem Cell Niche stem cells Stem Cells - cytology Stem Cells - metabolism Transforming Growth Factor beta - metabolism Wnt Proteins - metabolism
ISSN:	1538-4101, 1551-4005, 1551-4005
Online Access:	Get full text
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