Topography of primitive reflexes in dementia: an F-18 fluorodeoxyglucose positron emission tomography study

Background and purpose Although primitive reflexes (PRs) are inhibited during the first years of childhood, they may reappear with brain injury. PRs have been linked to frontal lobe dysfunction, but their precise topography has not yet been defined. The purpose of this study was to map which regions...

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Vydáno v:European journal of neurology Ročník 22; číslo 8; s. 1201 - 1207
Hlavní autoři: Matias-Guiu, J. A., Cabrera-Martín, M. N., Fernádez-Matarrubia, M., Moreno-Ramos, T., Valles-Salgado, M., Porta-Etessam, J., Carreras, J. L., Matias-Guiu, J.
Médium: Journal Article
Jazyk:angličtina
Vydáno: England Blackwell Publishing Ltd 01.08.2015
John Wiley & Sons, Inc
Témata:
Aged
Aged, 80 and over
Alzheimer Disease - metabolism
Alzheimer Disease - physiopathology
Alzheimer's disease
dementia
Dementia - metabolism
Dementia - physiopathology
Female
Fluorodeoxyglucose F18
Frontotemporal Dementia - metabolism
Frontotemporal Dementia - physiopathology
Humans
Male
Middle Aged
neurological examination
positron emission tomography
Positron-Emission Tomography - methods
Prefrontal Cortex - metabolism
primitive reflexes
Prospective Studies
Putamen - metabolism
Reflex - physiology
Thalamus - metabolism
dementia
primitive reflexes
positron emission tomography
Alzheimer's disease
neurological examination
ISSN:1351-5101, 1468-1331
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Shrnutí:Background and purpose Although primitive reflexes (PRs) are inhibited during the first years of childhood, they may reappear with brain injury. PRs have been linked to frontal lobe dysfunction, but their precise topography has not yet been defined. The purpose of this study was to map which regions of the brain display a reduced glucose metabolism in patients with cognitive impairment and PRs. Methods A prospective study was conducted to evaluate PRs in a group of patients assessed due to suspected cognitive decline. Neurological and neuropsychological examinations and 18F‐fluorodeoxyglucose positron emission tomography fused with computerized tomography were performed. Voxel‐based brain mapping analysis by means of statistical parametric mapping was used to compare patients with and without PRs. Results The study included 99 patients (33 diagnosed with Alzheimer's disease, 33 on the frontotemporal dementia spectrum and 33 with other diagnoses). Mean age was 71 ± 9.7 years; time since symptom onset was 3.6 ± 2.9 years. At least one PR was observed in 43 cases (43.4% of the whole sample; 48.5% in the Alzheimer disease group, 63.6% in frontotemporal dementia and 18.2% in the group with other diagnoses). The group of patients with PRs exhibited a decreased cerebral metabolism in the bilateral superior frontal gyri (Brodmann area 6), bilateral putamina and thalami. Conclusions The presence of PRs was associated with hypometabolism at the superior frontal gyrus and putamen. This suggests that dysfunction in the corticostriatal motor circuit (supplementary motor area–putamen–thalamus) may constitute the anatomical basis of the recurrence of PRs.
Bibliografie:istex:8EAC0D5F81EFAC0E533D673B3F0B9434EB22B881
Figure S1. SPM map. Regions with lower metabolism in PRs (two or more, in red), AD group (green) and FTD spectrum (blue) in comparison to healthy controls are shown.Table S1. Healthy control group (n = 9). Demographic characteristics and neuropsychological data. Table S2. Age Related White Matter Changes (ARWMC) scale according to each region.
ArticleID:ENE12726
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ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:1351-5101
1468-1331
DOI:10.1111/ene.12726