Pyruvate imbalance mediates metabolic reprogramming and mimics lifespan extension by dietary restriction in Caenorhabditis elegans

Summary Dietary restriction (DR) is the most universal intervention known to extend animal lifespan. DR also prevents tumor development in mammals, and this effect requires the tumor suppressor PTEN. However, the metabolic and cellular processes that underly the beneficial effects of DR are poorly u...

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Veröffentlicht in:	Aging cell Jg. 10; H. 1; S. 39 - 54
Hauptverfasser:	Mouchiroud, Laurent, Molin, Laurent, Kasturi, Prasad, Triba, Mohamed N., Dumas, Marc Emmanuel, Wilson, Marieangela C., Halestrap, Andrew P., Roussel, Damien, Masse, Ingrid, Dallière, Nicolas, Ségalat, Laurent, Billaud, Marc, Solari, Florence
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Oxford, UK Blackwell Publishing Ltd 01.02.2011 John Wiley & Sons, Inc Wiley Open Access
Schlagworte:	Animals Biochemistry, Molecular Biology Caenorhabditis elegans Caenorhabditis elegans - genetics Caenorhabditis elegans - metabolism Caenorhabditis elegans Proteins Caenorhabditis elegans Proteins - genetics Caenorhabditis elegans Proteins - metabolism Caenorhabditis elegans Proteins - physiology Caloric Restriction dietary restriction Epistasis, Genetic Epistasis, Genetic - physiology High-Throughput Screening Assays hormesis Life Sciences Longevity Longevity - genetics Membrane Transport Proteins Membrane Transport Proteins - genetics Membrane Transport Proteins - metabolism Metabolic Phenomena Metabolism - genetics Mitochondria Mitochondria - genetics Mitochondria - metabolism Molecular biology Monocarboxylic Acid Transporters Monocarboxylic Acid Transporters - genetics Monocarboxylic Acid Transporters - metabolism Mutation Mutation - physiology Oxidative Stress PTEN Phosphohydrolase PTEN Phosphohydrolase - physiology PTEN/daf‐18 pyruvate Pyruvate Dehydrogenase Complex Pyruvate Dehydrogenase Complex - metabolism Pyruvic Acid Pyruvic Acid - metabolism RNA Interference Signal Transduction Signal Transduction - genetics Transcription Factors Transcription Factors - genetics Transcription Factors - metabolism daf-18 OXIDATIVE STRESS TRANSPORTERS PTEN pyruvate Caenorhabditis elegans INSULIN-RECEPTOR INDUCED LONGEVITY GROWTH DISEASE CALORIC RESTRICTION DAF-16/FOXO MICE C-ELEGANS hormesis dietary restriction
ISSN:	1474-9718, 1474-9726, 1474-9726, 1474-9728
Online-Zugang:	Volltext
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