A genomic and functional inventory of deubiquitinating enzymes

Posttranslational modification of proteins by the small molecule ubiquitin is a key regulatory event, and the enzymes catalyzing these modifications have been the focus of many studies. Deubiquitinating enzymes, which mediate the removal and processing of ubiquitin, may be functionally as important...

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Vydáno v:Cell Ročník 123; číslo 5; s. 773
Hlavní autoři: Nijman, Sebastian M B, Luna-Vargas, Mark P A, Velds, Arno, Brummelkamp, Thijn R, Dirac, Annette M G, Sixma, Titia K, Bernards, René
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States 02.12.2005
Témata:
Amino Acid Motifs
Animals
Chromatin - chemistry
Chromatin - metabolism
Endocytosis - physiology
Endopeptidases - chemistry
Endopeptidases - classification
Endopeptidases - genetics
Endopeptidases - metabolism
Genome, Human
Humans
Hydrolases - chemistry
Hydrolases - classification
Hydrolases - genetics
Hydrolases - metabolism
Models, Molecular
Phylogeny
Proteasome Endopeptidase Complex - metabolism
Protein Conformation
Protein Processing, Post-Translational
Substrate Specificity
Ubiquitin - metabolism
ISSN:0092-8674
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Popis
Shrnutí:Posttranslational modification of proteins by the small molecule ubiquitin is a key regulatory event, and the enzymes catalyzing these modifications have been the focus of many studies. Deubiquitinating enzymes, which mediate the removal and processing of ubiquitin, may be functionally as important but are less well understood. Here, we present an inventory of the deubiquitinating enzymes encoded in the human genome. In addition, we review the literature concerning these enzymes, with particular emphasis on their function, specificity, and the regulation of their activity.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
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ISSN:0092-8674
DOI:10.1016/j.cell.2005.11.007