The effects of olibanum administered to methimazole-treated dams during lactation on learning and memory of offspring rats

The effect of olibanum administered during lactation to methimazole-treated dams on the learning of offspring was evaluated. The animals were treated for 60 days from the first day of lactation period: group 1 - tap water, group 2-0.03% methimazole and groups 3 and 4-0.03% methimazole with 0.25% or...

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Vydané v:Natural product research Ročník 26; číslo 16; s. 1544 - 1548
Hlavní autori: Hosseini, Mahmoud, Shafei, Mohammad Naser, Safari, Vajiheh, Taiarani, Zahra, Kafami Ladani, marzieh, Sadeghian, Reihaneh
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: England Taylor & Francis Group 01.08.2012
Predmet:
Animals
blood serum
Boswellia - chemistry
Female
hypothyroidism
lactation
Lactation - drug effects
learning
Learning - drug effects
Male
memory
Memory - drug effects
Methimazole - pharmacology
offspring
olibanum
Plant Preparations - therapeutic use
Pregnancy
Prenatal Exposure Delayed Effects - drug therapy
progeny
rat
Rats
tap water
thyroxine
ISSN:1478-6419, 1478-6427, 1478-6427
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Shrnutí:The effect of olibanum administered during lactation to methimazole-treated dams on the learning of offspring was evaluated. The animals were treated for 60 days from the first day of lactation period: group 1 - tap water, group 2-0.03% methimazole and groups 3 and 4-0.03% methimazole with 0.25% or 0.125% olibanum, respectively. The serum thyroxin level in the offspring of group 2 was significantly lower than that of group 1. However, there was no difference compared to groups 3 and 4. In a Morris water maze, the distance and time latency to reach the platform in offspring of group 2 was significantly higher than groups 1, 3 and 4. In probe trial, the time spent in target quadrant (Q 1 ) by offspring of group 2 was lower than groups 1, 3 and 4. It is suggested that impaired learning and memory in the offspring of hypothyroid rats may be prevented by olibanum.
Bibliografia:ObjectType-Article-1
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ISSN:1478-6419
1478-6427
1478-6427
DOI:10.1080/14786419.2011.566223