Global proteomics and pathway analysis of pressure-overload-induced heart failure and its attenuation by mitochondrial-targeted peptides

We investigated the protective effects of mitochondrial-targeted antioxidant and protective peptides, Szeto-Schiller (SS) 31 and SS20, on cardiac function, proteomic remodeling, and signaling pathways. We applied an improved label-free shotgun proteomics approach to evaluate the global proteomics ch...

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Bibliographic Details
Published in:	Circulation. Heart failure Vol. 6; no. 5; p. 1067
Main Authors:	Dai, Dao-Fu, Hsieh, Edward J, Chen, Tony, Menendez, Lorena G, Basisty, Nathan B, Tsai, Lauren, Beyer, Richard P, Crispin, David A, Shulman, Nicholas J, Szeto, Hazel H, Tian, Rong, MacCoss, Michael J, Rabinovitch, Peter S
Format:	Journal Article
Language:	English
Published:	United States 01.09.2013
Subjects:	Animals Antioxidants - pharmacology Aorta - physiopathology Aorta - surgery Arterial Pressure Disease Models, Animal Heart Failure - etiology Heart Failure - metabolism Heart Failure - pathology Heart Failure - physiopathology Heart Failure - prevention & control Ligation Male Mice Mice, Inbred C57BL Mitochondria, Heart - drug effects Mitochondria, Heart - metabolism Mitochondria, Heart - pathology Myocardium - metabolism Myocardium - pathology Oligopeptides - pharmacology Proteomics - methods Signal Transduction - drug effects Ventricular Remodeling - drug effects heart failure proteomics signal transduction mitochondria
ISSN:	1941-3297, 1941-3297
Online Access:	Get more information
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